Substituted 3-Benzylcoumarins as Allosteric MEK1 Inhibitors: Design, Synthesis and Biological Evaluation as Antiviral Agents

ATP Non-Competitive Ser/Thr Kinase Inhibitors as Potential Anticancer Agents

(2012) Giorgio Cozza et al.   Anti-Cancer Agents in Medicinal Chemistry

Discovery of Novel Allosteric Mitogen-Activated Protein Kinase Kinase (MEK) 1,2 Inhibitors Possessing Bidentate Ser212 Interactions

(2012) Robert A. Heald et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulation of Hepatitis C virus replication and gene expression by the MAPK-ERK pathway

(2012) Rongjuan Pei et al.   VIROLOGICA SINICA

MEK1–ERKs signal cascade is required for the replication of Enterovirus 71 (EV71)

(2011) Bo Wang et al.   ANTIVIRAL RESEARCH

MEK inhibitors: a patent review 2008 – 2010

(2011) John I Trujillo   EXPERT OPINION ON THERAPEUTIC PATENTS

From basic research to clinical development of MEK1/2 inhibitors for cancer therapy

(2010) Christophe Frémin et al.   Journal of Hematology & Oncology

Asymmetric conjugate additions to 1,1′-diactivated cyclic enones—a comparative study

(2009) Xiaoping Tang et al.   TETRAHEDRON-ASYMMETRY

Non-ATP-competitive kinase inhibitors – enhancing selectivity through new inhibition strategies

(2008) Stephen Harrison et al.   Expert Opinion on Drug Discovery

Putative allosteric MEK1 and MEK2 inhibitors

(2008) Steve Price   EXPERT OPINION ON THERAPEUTIC PATENTS

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS