Journal
MOLECULES
Volume 18, Issue 9, Pages 10352-10366Publisher
MDPI AG
DOI: 10.3390/molecules180910352
Keywords
Panax notoginseng; root; protopanaxatriol type saponins; L6 cell; mitochondrial oxidative stress
Funding
- Program for New Century Excellent Talents in University [NCET-10-0958, NCET-12-1069]
- Applied Basic and Advanced Research Program of Tianjin [10ZCKFSY09300]
- Ministry of Science and Technology of China [2011ZX09307-002-01]
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Seven new protopanaxatriol type saponins, 20S-sanchirhinosides A(1) (1), A(2) (2), A(3) (3), A(4) (4), A(5) (5), and A(6) (6), and sanchirhinoside B (7) were obtained as minor constituents from the root extract of Panax notoginseng (Burkill, F. H. Chen), which showed protection effects against antimycin A induced mitochondrial oxidative stress. Their structures were elucidated by chemical and spectroscopic methods (IR, HRESI-TOF-MS, 1D and 2D NMR). Among them, compounds 4, 6 and 7 showed significant protective effects against antimycin A-induced L6 cell injury.
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