Article
Medicine, General & Internal
Manley T. F. Huang, Vikram Sharma, Andrew Mendelsohn, Qisheng Wei, Jinjing Li, Bo Yu, James W. Larrick, Lawrence G. Lum
Summary: Bispecific antibody (BiAb)-armed activated T cells (BATs) show promise as a novel adoptive T cell therapy platform for treating various types of cancer.
ANNALS OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Piotr Szpakowski, Dominika Ksiazek-Winiarek, Malgorzata Turniak-Kusy, Ilona Pacan, Andrzej Glabinski
Summary: Astrocytes, once considered passive brain cells, have been found to play a more active role in the central nervous system. This study aimed to evaluate the production of inflammatory chemokines and neurotrophic factors by primary human astrocytes after inflammatory or anti-inflammatory stimulation. The results showed that only astrocytes induced by inflammatory mediators produced certain chemokines, and pro-inflammatory conditions decreased the release of a neurotrophic factor while anti-inflammatory cytokines increased its production.
Article
Chemistry, Medicinal
Sin -Min Li, Jia-Yu Chou, Shuo-En Tsai, Ching-Chun Tseng, Cheng-Yen Chung, Wei-Zheng Zeng, Yu-Pei Hu, Naoto Uramaru, Guan-Jhong Huang, Fung-Fuh Wong
Summary: An efficient synthesis method was developed for furoxan/1,2,4-triazole hybrids 5a-k from methyl 5-(halomethyl)-1-aryl-1H-1,2,4-triazole-3-carboxylates 1 through two-steps reaction including hydrolyzation and esterification. The newly synthesized compounds were evaluated for their exogenous NO release ability, in vitro and in vivo anti-inflammatory activity, and in silico predictions. Compound 5f showed extraordinary COX-2 inhibition and selectivity, as well as better inhibition of cytokine and gastric safety compared to Indomethacin. Molecular modeling and in silico predictions identified compound 5f as a potential anti-inflammatory agent with comparable effects to Celecoxib.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Damian Pawelski, Alicja Walewska, Sylwia Ksiezak, Dariusz Sredzinski, Piotr Radziwon, Marcin Moniuszko, Ramesh Gandusekar, Andrzej Eljaszewicz, Ryszard Lazny, Krzysztof Brzezinski, Marta E. Plonska-Brzezinska
Summary: The study aims to synthesize monocarbonyl analogs of curcumin to improve its bioavailability, with ten new analogs successfully synthesized and tested for cytotoxicity and anti-inflammatory properties in vitro.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Kalu K. Asanka Sanjeewa, Kalahe H. I. N. M. Herath, Hye-Won Yang, Cheol Soo Choi, You-Jin Jeon
Summary: Fucoidans are sulfated heteropolysaccharides found in brown seaweeds and some marine invertebrates, with promising bioactive properties such as antioxidant, immunomodulatory, anti-inflammatory, antiobesity, antidiabetic, and anticancer properties. Controlled inflammatory responses are beneficial, but chronic inflammatory responses are often associated with the pathogenesis of various diseases.
Review
Biochemistry & Molecular Biology
Monika Zajkowska, Barbara Mroczko
Summary: The liver plays crucial functions in the human body, but it is susceptible to damage from various factors, leading to liver diseases such as primary liver cancer. Chemokines have been found to play a significant role in the development of liver cancer, making them useful in detecting and monitoring the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Rheumatology
Aaron Z. Reyes, Kelly A. Hu, Jacob Teperman, Theresa L. Wampler Muskardin, Jean-Claude Tardif, Binita Shah, Michael H. Pillinger
Summary: The search for effective COVID-19 management strategies is ongoing, with colchicine showing promise in targeting multiple mechanisms associated with excessive inflammation. Outpatient treatment with colchicine could potentially reduce the need for hospitalization and mortality due to COVID-19, benefiting both resource-replete and resource-poor regions by reducing the demand for rare or expensive care resources.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Imke Atreya, Markus F. Neurath
Summary: The successful treatment of advanced colorectal cancer remains a challenge due to low immunogenicity. Enhancing the accumulation of cytolytic effector T lymphocytes and other cellular mediators is targeted for improved outcomes. Studying the molecular mechanisms and cellular interactions in the tumor microenvironment is crucial for identifying new therapeutic targets.
Article
Biochemistry & Molecular Biology
Valeriia V. Sennikova, Alena Zalaltdinova, Yulia M. Sadykova, Ayrat R. Khamatgalimov, Almir S. Gazizov, Alexandra D. Voloshina, Anna P. Lyubina, Syumbelya K. Amerhanova, Julia K. Voronina, Elena A. Chugunova, Nurbol O. Appazov, Alexander R. Burilov, Michail A. Pudovik
Summary: We present a regio- and diastereoselective synthesis of novel pyrrolidine-fused spiro-dihydrophosphacoumarins through intermolecular [3 + 2] cycloaddition reaction. This method complements existing approaches and provides an easy way to obtain otherwise inaccessible derivatives. Additionally, we describe the unprecedented pathway of the reaction between 4-hydroxycoumarin and azomethine ylides. The most potent compound showed 2.6-fold higher anti-cancer activity against the HuTu 80 cell line compared to 5-fluorouracil, with a selectivity index > 32.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Jing Zhang, Miaomiao Jiang, Hui Zhao, Lan Han, Yu Jin, Weidong Chen, Jianqing Wang, Ziyu Zhang, Can Peng
Summary: POC, a novel therapeutic compound for ischemic stroke, was successfully synthesized by conjugating paeonol and ozagrel. In vitro and in vivo studies demonstrated significant curative and therapeutic effects of POC on ischemic stroke.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Mohd Mughees, Jyoti Bala Kaushal, Gunjan Sharma, Saima Wajid, Surinder Kumar Batra, Jawed Akhtar Siddiqui
Summary: Chemokines play a crucial role in tumorigenesis and cancer progression, particularly in prostate cancer. Inflammatory processes and the secretion of chemokines and cytokines in the tumor microenvironment play a key role in cancer development and treatment resistance.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Cell Biology
Lavanya Goodla, Xiang Xue
Summary: This brief review discusses the involvement of three representative cytokines (TNF-alpha, IL-6 and IL-1 beta), a lipid molecule PGE2 and two chemokines (CXCL1 and CXCL2) in the process of CRC liver metastases.
Review
Chemistry, Inorganic & Nuclear
Huzaifa Yasir Khan, Sabiha Parveen, Imtiyaz Yousuf, Sartaj Tabassum, Farukh Arjmand
Summary: Metal complexes of non-steroidal anti-inflammatory drugs (NSAIDs) have gained attention in anti-tumor drug therapy. By selecting suitable metal ions and coordination geometries, NSAID-metal conjugates can be fine-tuned for targeted therapies. Metal complexes exhibit intriguing behavior in vivo, interacting with intracellular molecules and targeting cancer cells, thus playing a significant role in cell inhibition processes.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Oncology
Lawrence G. Lum, Zaid Al-Kadhimi, Abhinav Deol, Vidya Kondadasula, Dana Schalk, Elyse Tomashewski, Patricia Steele, Kristie Fields, Melissa Giroux, Qin Liu, Lawrence Flaherty, Michael Simon, Archana Thakur
Summary: The study evaluated the efficacy and immune responses of HER2 BATs in metastatic HER2- breast cancer as immune consolidation after chemotherapy. Results showed that HER2 BATs increased the proportion of patients who were stable at 4 months, improved overall survival, and enhanced antitumor immune responses. Future studies combining HER2 BATs with checkpoint inhibitors or other immunomodulators may further improve clinical outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Xiao-Long Sun, Mei-Lin Zhu, Yi-Qun Dai, Hong-Mei Li, Bo-Han Li, Hui Ma, Chang-Hao Zhang, Cheng-Zhu Wu
Summary: In this study, 15 semi-synthesized MAG derivatives were evaluated for their in vitro anticancer activities, and compound 6a showed the best cytotoxic activity against four human cancer cell lines. Furthermore, compound 6a was found to significantly inhibit the migration and invasion of MDA-MB-231 cells, and downregulate the expression of HIF-1 alpha, MMP-2, and MMP-9 in a concentration-dependent manner in Western blot experiments. These results suggest that substituting a benzyl group having F atoms at the C2 position on MAG is a viable strategy for optimizing MAG derivatives as anticancer agents.