Bio-Activity and Dereplication-Based Discovery of Ophiobolins and Other Fungal Secondary Metabolites Targeting Leukemia Cells

3-Anhydro-6-hydroxy-ophiobolin A, a new sesterterpene inhibiting the growth of methicillin-resistant Staphylococcus aureus and inducing the cell death by apoptosis on K562, from the phytopathogenic fungus Bipolaris oryzae

(2013) Quan-Xin Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ophiobolins P–T, five new cytotoxic and antibacterial sesterterpenes from the endolichenic fungus Ulocladium sp.

(2013) Quan-Xin Wang et al.   FITOTERAPIA

Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity

(2013) MARINA BURY et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Anticancer and Antifungal Compounds from Aspergillus, Penicillium and Other Filamentous Fungi

(2013) Tanja Bladt et al.   MOLECULES

Identification of Ophiobolin F Synthase by a Genome Mining Approach: A Sesterterpene Synthase from Aspergillus clavatus

(2013) Ryota Chiba et al.   ORGANIC LETTERS

Coming full circle: 70 years of chronic lymphocytic leukemia cell redistribution, from glucocorticoids to inhibitors of B-cell receptor signaling

(2012) J. A. Burger et al.   BLOOD

Novel and Emerging Drugs for Chronic Lymphocytic Leukemia

(2012) S. Isfort et al.   CURRENT CANCER DRUG TARGETS

Chronic Lymphocytic Leukemia Therapy: Beyond Chemoimmunotherapy

(2012) Julio Delgado et al.   CURRENT PHARMACEUTICAL DESIGN

Asperjinone, a Nor-Neolignan, and Terrein, a Suppressor of ABCG2-Expressing Breast Cancer Cells, from Thermophilic Aspergillus terreus

(2012) Wen-Ying Liao et al.   JOURNAL OF NATURAL PRODUCTS

The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways

(2011) Tingting Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dereplication of Microbial Natural Products by LC-DAD-TOFMS

(2011) Kristian F. Nielsen et al.   JOURNAL OF NATURAL PRODUCTS

New taxa in Aspergillus section Usti

(2011) R.A. Samson et al.   STUDIES IN MYCOLOGY

Soluble CD14 is a novel monocyte-derived survival factor for chronic lymphocytic leukemia cells, which is induced by CLL cells in vitro and present at abnormally high levels in vivo

(2010) M. Seiffert et al.   BLOOD

Fusicoccin-A selectively induces apoptosis in tumor cells after interferon-α priming

(2010) Ingrid J. de Vries-van Leeuwen et al.   CANCER LETTERS

Effect of the sesterterpene-type metabolites, ophiobolins A and B, on zygomycetes fungi

(2010) Krisztina Krizsán et al.   FEMS MICROBIOLOGY LETTERS

Inflammatory cytokines and signaling pathways are associated with survival of primary chronic lymphocytic leukemia cells in vitro: a dominant role of CCL2

(2010) A. Schulz et al.   HAEMATOLOGICA

Explorative Solid-Phase Extraction (E-SPE) for Accelerated Microbial Natural Product Discovery, Dereplication, and Purification

(2010) Maria Månsson et al.   JOURNAL OF NATURAL PRODUCTS

Treatment of patients with fludarabine-refractory chronic lymphocytic leukemia: need for new treatment options

(2010) Apostolia-Maria Tsimberidou et al.   LEUKEMIA & LYMPHOMA