Article
Biochemistry & Molecular Biology
Jedrzej Kozak, Katarzyna Tyszczuk-Rotko, Radovan Metelka
Summary: In this paper, a highly sensitive voltammetric sensor for the determination of the anti-cancer antibiotic bleomycin (BLM) was developed. This sensor is based on a screen-printed carbon sensor that is electrochemically pretreated and decorated with lead nanoparticles in the sample solution. The sensor exhibited low limits of detection and quantification, a wide linear range, and high sensitivity. It was successfully applied for the determination of BLM in wastewater and human urine samples.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Paula Enzian, Ramtin Rahmanzadeh
Summary: This study aimed to improve the intracellular availability of the anti-tumor medication Bleomycin through Photochemical Internalization (PCI) for the treatment of head and neck squamous cell carcinoma (HNSCC). After optimization, the same level of tumor cell death was achieved with a 20-fold lower Bleomycin concentration, reducing the side effects of Bleomycin and increasing its efficacy as an anti-tumor medication when combined with PCI.
Article
Chemistry, Multidisciplinary
Magnus Klove, Rasmus Stubkjaer Christensen, Ida Gjerlevsen Nielsen, Sanna Sommer, Mads Ry Vogel Jorgensen, Ann-Christin Dippel, Bo Brummerstedt Iversen
Summary: The structures of Zr4+ ions in solution were studied using X-ray pair distribution function (PDF) analysis. It was found that [Zr-4(OH)8(OH2)16]8+ tetramers are predominant in water, while monomeric complexes exist in non-aqueous solvents. The PDF analysis also revealed second sphere coordination of chloride counter ions to the aqueous tetramers.
Article
Biochemistry & Molecular Biology
Dalibor Kosek, Alison B. Hickman, Rodolfo Ghirlando, Susu He, Fred Dyda
Summary: Copy-out/paste-in transposition is a major bacterial DNA mobility pathway that contributes significantly to the emergence of antibiotic resistance by upregulating downstream gene expression. This pathway requires both asymmetric and symmetric strand transfer steps and involves an unusual asymmetric dimeric transpososome during transposition.
Article
Environmental Sciences
Jiaolong Ying, Xiaopeng Qin, Zhanhao Zhang, Fei Liu
Summary: The study demonstrated that birnessite effectively removes lincomycin from aqueous solution and the removal process follows a second-order model. The presence of cations inhibited the removal of lincomycin, while the addition of certain anions improved the efficiency of birnessite. Mn(IV) and Mn(III) were identified as core manganese species crucial for lincomycin removal. These findings shed light on the removal process of lincomycin and the impact of cations and anions on similar pollutant removal by birnessite.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Jovan Damjanovic, Jiayuan Miao, He Huang, Yu-Shan Lin
Summary: Protein-protein interactions play a crucial role in biological processes, but targeting their interfaces with small molecules can be challenging. Cyclic peptides have emerged as promising modulators of these interactions, with FDA-approved examples and ongoing development in various therapeutic areas. However, designing new cyclic peptides faces obstacles such as structural characterization, which can be addressed with advanced molecular dynamics simulations. These simulations have evolved from explanatory tools to systematic methods for studying and designing cyclic peptide therapeutics.
Review
Microbiology
Eleonora Cella, Marta Giovanetti, Francesca Benedetti, Fabio Scarpa, Catherine Johnston, Alessandra Borsetti, Giancarlo Ceccarelli, Taj Azarian, Davide Zella, Massimo Ciccozzi
Summary: Antibiotic resistance is a significant global health concern that requires a collaborative One Health approach. It poses a threat to human and animal health, as well as the effectiveness of medical treatments and veterinary interventions.
Review
Multidisciplinary Sciences
Ton N. Schumacher, Daniela S. Thommen
Summary: This article discusses the current knowledge on TLSs in cancer, focusing on the drivers of TLS formation, the function and contribution of TLSs to the antitumor immune response, and the potential of TLSs as therapeutic targets in human cancers.
Review
Chemistry, Physical
Federica Buccino, Giada Martinoia, Laura Maria Vergani
Summary: This review discusses the challenges of preventing torsional failure, emphasizing the lack of deep and systematic treatment in current research. By comparing accidents and breaks caused by torsion, the limitations of conventional design structures are highlighted, pointing towards a nature-driven analysis of novel solutions inspired by plant structures.
Article
Oncology
Anna Myriam Perrone, Giacomo Corrado, Camelia Alexandra Coada, Giorgia Garganese, Simona Maria Fragomeni, Luca Tagliaferri, Stella Di Costanzo, Eugenia De Crescenzo, Alessio Giuseppe Morganti, Martina Ferioli, Francesca De Terlizzi, Giovanni Scambia, Pierandrea De Iaco
Summary: A multicenter observational study was conducted to evaluate the 5-year outcomes of electrochemotherapy in older patients with recurrent vulvar cancer. The results showed that 32% of patients with complete response were disease-free after 2 years. Patients with partial response had a median progression-free survival of 15.36 months, while those with stable or progressive disease experienced tumor relapse after 6.95 and 3.26 months, respectively. Median overall survival ranged from 18.77 to 11.13 months in different response groups. This study suggests that electrochemotherapy may be a potential alternative for vulvar cancer patients, and further research is needed.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Mathematics, Applied
Xiao Liu, Jianlin Xia, Maarten de Hoop, Xiaofeng Ou
Summary: A new fast elliptic solver is proposed using an interconnected hierarchical rank structure and structured approximations, significantly reducing the amount of compression operations while preserving rank structures and reducing costs. This solver utilizes interconnected structures to reuse off-diagonal basis matrices across multiple hierarchical levels, avoiding the need for explicit low-rank compression operations. Numerical tests demonstrate the efficiency and speedup of this approach, with significant reductions in low-rank compression operations.
JOURNAL OF SCIENTIFIC COMPUTING
(2022)
Article
Agricultural Engineering
Jiaying Song, Lun Lu, Jian Wang, Xue Li, Jinying Li, Qianwen Wang, Haiyan Du, Shuaishuai Xin, Lina Xu, Qinghua Yan, Chengzhi Zhou, Guocheng Liu, Yanjun Xin
Summary: Nano Y2O3-modified biochar composites (Y2O3@BC600) were successfully fabricated and demonstrated excellent adsorption capacity for oxytetracycline (OTC). Y2O3@BC600-1:4 exhibited a Langmuir adsorption capacity for OTC of 223.46 mg/g, which was 10.52 times higher than that of BC600. The enhanced adsorption performance of Y2O3@BC600-1:4 could be attributed to the higher dispersion of Y2O3 nanoparticles, increased surface area of 175.65 m(2)/g, and expanded porosity of 0.27 cm(3)/g.
BIORESOURCE TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Wenjia Mao, Xinting Wang, Xiaoli Hu, Zhongmin Su
Summary: A novel heterogeneous catalyst, CUST-564, based on a transition metal was successfully synthesized and utilized for the elimination of tetracycline in aqueous solution through peroxymonosulfate (PMS) activation. The CUST-564/PMS/TC system exhibited a superior degradation rate compared to other systems, and the factors influencing PMS activation were investigated.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Environmental Sciences
Kubra Ulucan-Altuntas, Senem Yazici Guvenc, Emine Can-Guven, Fatih Ilhan, Gamze Varank
Summary: This study investigated the degradation of oxytetracycline by heat-activated peroxydisulfate and peroxymonosulfate processes. Response surface methodology was used to evaluate the effect of process parameters on oxytetracycline removal efficiency, showing significant results for both processes. The predicted oxytetracycline removal efficiencies for the PDS and PMS processes were 89.7% and 84.0%, respectively, with the PDS process having higher kinetic constants at all pH values than the PMS process.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Infectious Diseases
Tilman E. Klassert, Cristina Zubiria-Barrera, Robert Neubert, Magdalena Stock, Antony Schneegans, Mercedes Lopez, Dominik Driesch, Gregor Zakonsky, Petra Gastmeier, Hortense Slevogt, Rasmus Leistner
Summary: This study investigates the effects of different sanitization strategies on the microbial structures and the ecological balance of the environmental microbiome in the clinical setting. The results show that probiotic sanitization leads to changes in the environmental microbiota and a significant reduction in antibiotic resistance genes.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
