4.6 Article

Optical Characterization of Oligonucleotide DNA Influenced by Magnetic Fields

Journal

MOLECULES
Volume 18, Issue 10, Pages 11797-11808

Publisher

MDPI AG
DOI: 10.3390/molecules181011797

Keywords

oligonucleotide DNA; magnetic field; refractive index; extinction coefficient

Funding

  1. IPPP [PV077/2012A]
  2. HIR [J-21002-73823, UM.C/HIR/MOHE/SC/06]
  3. FRGS [FP004-2013A]
  4. University Malaya Research Grant [UMRG:RG066/09AFR, RP007B-13AFR]

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UV-VIS spectroscopic analysis of oligonucleotide DNA exposed to different magnetic fields was performed in order to investigate the relationship between DNA extinction coefficients and optical parameters according to magnetic-field strength. The results with the oligonucleotides adenine-thymine 100 mer (AT-100 DNA) and cytosine-guanine 100 mer (CG-100 DNA) indicate that the magnetic field influences DNA molar extinction coefficients and refractive indexes. The imaginary parts of the refractive index and molar extinction coefficients of the AT-100 and CG-100 DNA decreased after exposure to a magnetic field of 750 mT due to cleavage of the DNA oligonucleotides into smaller segments.

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