Article
Veterinary Sciences
Amira M. Shaban, Mai Raslan, Zeina Walid Sharawi, Mohamed Sayed Abdelhameed, Ola Hammouda, Hossam M. El-Masry, Khaled N. M. Elsayed, Mohammed A. El-Magd
Summary: Camel milk exosomes (CM-EXOs) from camel milk have antimicrobial and anticancer effects, exhibiting bacteriostatic and fungistatic effects on certain bacteria and fungi, while selectively inducing apoptosis in cancer cells but not normal cells. CM-EXOs also promote the production of reactive oxygen species and reduce antioxidant status in cancer cells. Overall, CM-EXOs have significant health-promoting effects.
VETERINARY SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Fatima Tuz Zahra, Aamer Saeed, Atteeque Ahmed, Hammad Ismail, Muhammad Umar Ijaz, Fernando Albericio
Summary: A series of novel compounds containing a 1,3 thiazole core were synthesized and their structures were confirmed using various analytical and spectral methods. These compounds exhibited significant antibacterial activity against Escherichia coli and Bacillus subtilis, as well as inhibitory activities against alpha-amylase, alpha-glucosidase, and urease. Compound 6d showed potent and selective inhibition of alpha-amylase, while compounds 6d and 6e exhibited prominent inhibition against alpha-glucosidase. Molecular docking studies revealed the binding mechanism and affinity of these new inhibitors within the binding sites of various amino acids.
Article
Chemistry, Multidisciplinary
Polina O. Serebrennikova, Julia A. Paznikova, Eva A. Kirnos, Irina A. Utepova, Elizaveta D. Kazakova, Vladimir F. Lazarev, Liubov S. Kuznetcova, Boris A. Margulis, Irina V. Guzhova, Oleg N. Chupakhin, Alexey P. Sarapultsev
Summary: The present study synthesized new derivatives of mono- and bis-1,2,4-triazoloazines and evaluated their cytotoxic activity against cancer cells. These compounds exhibited significant toxicity towards tumor cells while having minimal effects on normal cells, suggesting their potential as effective and selective anticancer agents.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Plant Sciences
Farzana Kausar, Kyung-Hwan Kim, Hafiz Muhammad Umer Farooqi, Muhammad Awais Farooqi, Muhammad Kaleem, Rooma Waqar, Atif Ali Khan Khalil, Fazli Khuda, Chethikkattuveli Salih Abdul Rahim, Kinam Hyun, Kyung-Hyun Choi, Abdul Samad Mumtaz
Summary: This study investigated the anticancer and antimicrobial activities of Prunus cornuta and Quercus semicarpifolia. The results showed significant inhibitory effects on various cancer cell lines and antibacterial effects against different strains.
Review
Chemistry, Multidisciplinary
Seyedmohammad Hosseininezhad, Ali Ramazani
Summary: Thiazole ring is an important heterocycle scaffold in organic and medicinal chemistry, with significant biological activities. This review highlights the advances in antimicrobial, anti-inflammatory, and anticancer activities of structures containing thiazole scaffold, and analyzes the effects of various groups on this scaffold. The results indicate that thiazole hybrids have potential antimicrobial, anti-inflammatory, and anticancer activities.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Infectious Diseases
Victor Kartsev, Athina Geronikaki, Alexander Zubenko, Anthi Petrou, Marija Ivanov, Jasmina Glamoclija, Marina Sokovic, Lyudmila Divaeva, Anatolii Morkovnik, Alexander Klimenko
Summary: In this study, the design, synthesis, and antimicrobial activity of new heteroaryl (aryl) thiazole derivatives were reported. The compounds demonstrated moderate antibacterial activity and better antifungal activity. Compound 3 showed the highest activity among the tested compounds.
Article
Pharmacology & Pharmacy
Mazen Mohammed Almehmadi, Osama Abdulaziz, Mohammad Asif
Summary: A series of new compounds were designed, synthesized and evaluated for their antibacterial and antifungal activities. Some of the synthesized compounds showed good antimicrobial activities.
LATIN AMERICAN JOURNAL OF PHARMACY
(2022)
Article
Chemistry, Organic
Hang Li, Si Shu, John A. Kalaitzis, Zhuo Shang, Daniel Vuong, Andrew Crombie, Ernest Lacey, Andrew M. Piggott, Yit-Heng Chooi
Summary: Activation of a cryptic polyketide synthase gene cluster hkn from Aspergillus hancockii by overexpressing the gene-cluster-specific transcription factor HknR led to the discovery of a novel polycyclic metabolite named hancockinone A. This compound, featuring a unique prenylated tetracyclic skeleton, exhibits moderate antibacterial activity and the role of cytochrome P450 HknE in constructing the five-membered ring in hancockinone A has been confirmed through heterologous expression, substrate feeding, and in vitro assays.
Article
Chemistry, Medicinal
Moataz A. Shaldam, Ahmed F. Khalil, Hadia Almahli, Maiy Y. Jaballah, Andrea Angeli, Eman F. Khaleel, Rehab Mustafa Badi, Eslam B. Elkaeed, Claudiu T. Supuran, Wagdy M. Eldehna, Haytham O. Tawfik
Summary: New 5-cyano-6-oxo-pyridine-based sulfonamides were designed and synthesized to potentially inhibit both EGFR and CA, with anticancer properties. The inhibitory effects on EGFR were observed, while the inhibitory effects on CA were affected by the neighboring methoxy group.
ARCHIV DER PHARMAZIE
(2023)
Article
Chemistry, Applied
Majid Zare-Bidaki, Pouria Mohammadparast-Tabas, Yasaman Peyghambari, Elham Chamani, Mahin Siami-Aliabad, Sobhan Mortazavi-Derazkola
Summary: The research synthesized biogenic silver nanoparticles using Pistacia khinjuk leaves extract as a reducing agent, showing high photocatalytic degradation of dyes, strong antibacterial, antifungal, and antioxidant activities, as well as significant anticancer effects.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Obaid Afzal, Amena Ali, Abuzer Ali, Abdulmalik Saleh Alfawaz Altamimi, Manal A. Alossaimi, Md Afroz Bakht, Mubarak A. Salahuddin, Mubarak A. Alamri, Md. Faiyaz Ahsan, Mohamed Jawed Ahsan, Ki-Young Kim, Rozangela Curi Pedrosa
Summary: We synthesized and evaluated a series of new 4-chloro-2-((5-aryl-1,3,4-oxadiazol-2-yl)amino)phenol analogues (6a-h) as potential anticancer and antibacterial agents. The compounds demonstrated significant anticancer activity against specific cancer cell lines and efficient binding to the active site of the target protein. 4-Chloro-2-((5-(4-nitrophenyl)-1,3,4oxadiazol-2-yl)amino)phenol (6c) showed the most promising antibacterial activity against both Gram-negative and Gram-positive bacteria.
Article
Pharmacology & Pharmacy
Saad Alghamdi, Mazen M. Almehmadi, Mustafa Halawi, Mehnaz Kamal, Mohammad Asif
Summary: In this research, a series of pyrazole derivatives were synthesized and evaluated for their antimicrobial and antifungal activities. The results showed that some of the derivatives exhibited significant activity against various strains.
LATIN AMERICAN JOURNAL OF PHARMACY
(2022)
Article
Chemistry, Organic
Jitendra Nalawade, Abhijit Shinde, Yogita K. Abhale, Yogesh Nandurkar, Vivek D. Bobade, Dhiman Sarkar, Pravin C. Mhaske
Summary: In this study, a series of novel 2'-aryl-4-aryl-2,4'-bisthiazole and 2'-aryl-4-pyridyl-2,4'-bisthiazole derivatives were synthesized and evaluated for their antibacterial and antifungal activities. Compounds 7b, 9d, 9g, 9i, and 9l exhibited excellent antibacterial activity against all tested strains. The results suggest that bisthiazole derivatives have the potential to be developed as lead compounds for treating microbial infections.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Infectious Diseases
Michelyne Haroun, Christophe Tratrat, Aggeliki Kolokotroni, Anthi Petrou, Athina Geronikaki, Marija Ivanov, Marina Kostic, Marina Sokovic, Alejandro Carazo, Premysl Mladenka, Nagaraja Sreeharsha, Katharigatta N. Venugopala, Anroop B. Nair, Heba S. Elsewedy
Summary: The newly synthesized 5-methylthiazole based thiazolidinones showed good antimicrobial activity against various bacteria and fungi, with some compounds demonstrating particularly strong inhibition against E. coli and B. cereus. Compound 12 exhibited the best antibacterial activity against MRSA, P. aeruginosa, and E. coli, surpassing reference drugs in efficacy. Molecular docking studies suggested that the compounds may inhibit certain enzymes to exert their antibacterial and antifungal activities.
Article
Polymer Science
Milena Ignatova, Nevena Manolova, Iliya Rashkov, Ani Georgieva, Reneta Toshkova, Nadya Markova
Summary: In this study, novel fibrous materials containing a model drug of the 8-hydroxyquinoline group were fabricated using a one-pot method. The materials showed good antibacterial and antifungal properties and significant cytotoxicity against cancer cells. These findings suggest the potential applications of these materials in wound healing and local therapy of cervical and breast cancer.
