Article
Chemistry, Physical
Serap Uzun, Zeynep Demircioglu, Esra Koc, Mustafa Ceylan
Summary: The title compounds of (I) and (II) were synthesized and characterized using FT-IR and NMR spectroscopic techniques. The solid state crystal structures were determined by X-ray diffraction, and intermolecular interactions were investigated using Hirshfeld and 2D fingerprint analyses. Molecular geometries were optimized using DFT/B3LYP methods, and various properties of the compounds were also explored.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Medicinal
Bo Fang, Yinshuang Lai, Hao Yan, Yue Ma, Zefeng Ni, Qianqian Zhu, Jianxia Zhang, Yanfei Ye, Mengying Wang, Peipei Wang, Yan Wang, Shuyuan Zhang, Min Hui, Dalong Wang, Yunjie Zhao, Xiaokun Li, Kun Wang, Zhiguo Liu
Summary: Aberrant FGFR4 signaling is implicated in cancer development, and this study reports a novel series of selective inhibitors targeting FGFR4 kinase. Compound 19g showed excellent kinase selectivity and cytotoxicity against colorectal cancer cell lines. It also demonstrated significant tumor inhibition in a mouse model and disrupted FGFR4 phosphorylation and downstream signaling. Compound 19g could be a potential candidate for colorectal cancer treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Pan Zhang, Zhi-Xiang Yu
Summary: This study presents a method to design new cross [2 + 2] reactions and successfully predicts and achieves the highly pursued bioisostere - bicyclo[3.1.1]heptane skeleton in pharmaceutical chemistry. The study reveals that the reaction is controlled by three patterns of regiochemical control: kinetic control, thermodynamic control, and dynamic control. Through understanding the reaction mechanism, the cross [2 + 2] reaction is successfully realized, further confirming the insights of this study.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Medicinal
Xuetao Chen, Fanying Meng, Jingtian Zhang, Zijian Zhang, Xuan Ye, Weikun Zhang, Yuanyuan Tong, Xinrui Ji, Rujun Xu, Xiao-Li Xu, Qi-Dong You, Zheng-Yu Jiang
Summary: Sepsis is a global health problem and BRD4 inhibitor 27 could be a potential candidate for sepsis treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Crystallography
Ali A. El-Emam, Lamya H. Al-Wahaibi, Olivier Blacque, Edward R. T. Tiekink
Summary: The compound is monoclinic with a molecular formula of C14H12N4O3S. The cell parameters are a = 12.2777(3) Å, b = 9.4312(2) Å, c = 12.9412(2) Å, and β = 107.945(2) degrees. The volume of the unit cell is 1425.61(5) Å^3, with a space group of P2(1)/n. The data was collected at 160 K.
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES
(2022)
Article
Chemistry, Inorganic & Nuclear
Dong-Yang Liu, Xiao-Xia Ren, Xiao-Min Ning, Mei-Hua Lin, Yuan-Di Wu, Jing Qian
Summary: Six new MOFs were synthesized under solvothermal conditions and their coordination configurations and fluorescence properties were investigated, revealing that metal ions play a crucial role in fluorescence emission. Additionally, the choice of solvents also significantly affects the fluorescence emission of the MOFs.
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
(2021)
Article
Chemistry, Physical
Serap Uzun, Zeynep Kelesoglu, Esra Koc, Mustafa Ceylan
Summary: The title compound was synthesized and characterized using various analytical techniques including X-ray diffraction, FT-IR, UV-Vis, TGA, and NMR spectroscopy. The crystal packing of the compound is governed by N-H...N, C-H...N hydrogen bonds, and C-H...pi interactions. Hirshfeld surface analysis confirms the existence of intermolecular interactions in the crystal. Theoretical computations, including NBO, FMOs, MEP, FF, and ECT, were performed using DFT at B3LYP level with the 6-311G(d,p) basis set. NBO analysis reveals the stability of the molecule due to hyperconjugative interactions and charge delocalization. Furthermore, the interaction between the title compound and DNA bases, particularly guanine, was investigated using the ECT method. Molecular docking study was conducted to determine the interaction states between the guanine DNA (PDB:4ENM) and the studied molecule.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Engineering, Environmental
Golshan Moradi, Rouhollah Heydari, Sirus Zinadini, Masoud Rahimi, Ali Akbar Zinatizadeh, Foad Gholami
Summary: In this study, a facile method was used to synthesize a new type of pectin-based material with high functionality and hydrophilicity. The obtained material was incorporated into a nanofiltration membrane, resulting in composite membranes with improved filtration performance and antifouling properties.
JOURNAL OF WATER PROCESS ENGINEERING
(2022)
Article
Chemistry, Physical
Jia Wang, Joshua H. Marks, Andrew M. Turner, Anatoliy A. Nikolayev, Valeriy Azyazov, Alexander M. Mebel, Ralf Kaiser
Summary: The formation pathways of hydroxyacetone, methyl acetate, and 3-hydroxypropanal, as well as their enol tautomers, within mixed ices analogous to interstellar ices have been unraveled for the first time. This study provides insights into the formation mechanisms of these molecules and suggests potential candidates for future astronomical searches.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Crystallography
Qiu Yu Zhang, Yu Yu
Summary: This is a crystal structure description of a substance called C15H18N4O, which belongs to the triclinic system.
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES
(2022)
Article
Chemistry, Inorganic & Nuclear
Ghodsi Mohammadi Ziarani, Mahdieh Khademi, Fatemeh Mohajer, Alireza Badiei, Rajender S. Varma
Summary: This paper reported the synthesis of 4'-amino-6'-methoxy-2-oxo-2H-spiro[acenaphthylene-1,2'-chromene]-3'carbonitrile compounds through a three-component reaction, and investigated their optical properties as a cyanide colorimetric sensor ion.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Organic
Osama Farouk, Magdy A. Ibrahim, Nasser M. El-Gohary
Summary: The study synthesized N-pyrimidinylacetamide and beta-chloroenaldehyde derivatives, and investigated their applications in chemical reactions and biological activities. These products serve as building blocks for nitrogen heterocyclic compounds.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Marwa Dhiabi, Ali Bouattour, Mehdi Fakhfakh, Souhir Abid, Ludovic Paquin, Thomas Robert, Stephane Bach, Jean-Pierre Bazureau, Houcine Ammar
Summary: The synthesis of 2-benzylamino-8-methoxy-4H-chromene-3-carbonitriles 7(a-e) was achieved through a four-step process, using reductive amination of 2-amino-8-methoxy-4H-chromene-3-carbonitrile 4 with para- and meta-substituted benzaldehydes 5(a-e). The resulting compounds 7(a-e) and their aldimines 6(a-e) were characterized using the Swiss ADME server platform and showed potential activity against Hs Pim1 and Hs Haspin protein kinases.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Queen S. Obu, Hitler Louis, Joseph O. Odey, Ishegbe Joyce Eko, Shuaibu Abdullahi, Tabe N. Ntui, Ofiong E. Offiong
Summary: The title compound was successfully synthesized and characterized both experimentally and theoretically, with results showing agreement between the two methods. The compound was analyzed for chemical reactivity and anti-tubercular activity, demonstrating strong binding affinities and potential anti-tubercular activity.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Organic
Nasser M. El-Gohary, Magdy A. Ibrahim, Osama Farouk
Summary: In this study, the electron deficient substrate 1 was utilized for the construction of novel heterocyclic rings bearing pyrimidine nucleus. The synthesized compounds exhibited variable inhibitory effect towards tested microorganisms, suggesting potential antimicrobial properties. The structures of the new synthesized products were established based on their analytical and spectral data.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Johannes C. Liermann, Nils E. Schloerer
MAGNETIC RESONANCE IN CHEMISTRY
(2018)
Article
Chemistry, Organic
Bassam Alameddine, Noorullah Baig, Suchetha Shetty, Fakhreia Al-Sagheer, Saleh Al-Mousawi
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2018)
Article
Chemistry, Organic
Moustafa S. Moustafa, Saleh M. Al-Mousawi
CURRENT ORGANIC CHEMISTRY
(2018)
Review
Chemistry, Organic
Moustafa Sherief Moustafa, Saleh Mohammed Al-Mousawi, Hesham R. El-Seedi, Mohamed Hilmy Elnagdi
CURRENT ORGANIC SYNTHESIS
(2018)
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Polymer Science
Bassam Alameddine, Noorullah Baig, Suchetha Shetty, Saleh Al-Mousawi, Fakhreia Al-Sagheer
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
(2018)
Review
Chemistry, Medicinal
Moustafa Sherief Moustafa, Saleh Mohammed Al-Mousawi, Hesham R. E-Seedi, Mohamed Hilmy Elnagdi
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2018)
Article
Polymer Science
Noorullah Baig, Suchetha Shetty, Saleh Al-Mousawi, Fakhreia Al-Sagheer, Bassam Alameddine
Article
Polymer Science
Bassam Alameddine, Noorullah Baig, Suchetha Shetty, Saleh Al-Mousawi, Fakhreia Al-Sagheer
Article
Chemistry, Applied
Noorullah Baig, Suchetha Shetty, Saleh Al-Mousawi, Fakhreia Al-Sagheer, Bassam Alameddine
REACTIVE & FUNCTIONAL POLYMERS
(2019)
Article
Chemistry, Medicinal
Shaden A. M. Khalifa, Nizar Elias, Mohamed A. Farag, Lei Chen, Aamer Saeed, Mohamed-Elamir F. Hegazy, Moustafa S. Moustafa, Aida Abd El-Wahed, Saleh M. Al-Mousawi, Syed G. Musharraf, Fang-Rong Chang, Arihiro Iwasaki, Kiyotake Suenaga, Muaaz Alajlani, Ulf Goransson, Hesham R. El-Seedi
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Polymer Science
Suchetha Shetty, Noorullah Baig, Saleh Al-Mousawi, Fakhreia Al-Sagheer, Bassam Alameddine
Article
Polymer Science
Bassam Alameddine, Noorullah Baig, Suchetha Shetty, Saleh Al-Mousawi
Review
Food Science & Technology
Shaden A. M. Khalifa, Mohamed A. Farag, Nermeen Yosri, Jamal S. M. Sabir, Aamer Saeed, Saleh Mohammed Al-Mousawi, Wafaa Taha, Syed Ghulam Musharraf, Seema Patel, Hesham R. El-Seedi
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2019)
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Chemistry, Multidisciplinary
Valentina M. Breising, Jacob M. Kayser, Anton Kehl, Dieter Schollmeyer, Johannes C. Liermann, Siegfried R. Waldvogel
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
N. Baig, S. Shetty, S. Al-Mousawi, E. Al-Sagheer, B. Alameddine
MATERIALS TODAY CHEMISTRY
(2018)