Article
Chemistry, Medicinal
Yuma Nakagawa, Tatsuya Hishida, Kimio Sumaru, Kana Morishita, Keita Kirito, Satoshi Yokojima, Yuki Sakamoto, Shinichiro Nakamura, Kingo Uchida
Summary: We have developed a novel technique for cell killing using diarylethene molecules as photo-isomerizing-molecular switches. These molecules are delivered to the cell nucleus, where a UV light irradiation switches them into a closed form that induces DNA intercalation. Subsequent blue light irradiation triggers cell killing, leading to DNA double-strand breaks. The unique photo-controllable action of these molecules provides a basis for a new phototherapy scheme.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Xiongwei Liu, Kuizhong Shan, Xiaxia Shao, Xianqing Shi, Yun He, Zhen Liu, Joe Antony Jacob, Lichun Deng
Summary: The biomimetic approach of synthesizing silver nanoparticles using Rhizophora apiculata leaf extract showed dose-dependent cytotoxic effects on HEK-293 and HeLa cells, being three times more toxic to HEK-293 cells compared to HeLa cells.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Virology
Shuang Cheng, Fei Zhao, Le Wen, Bo Yang, Xian-Zhang Wang, Sheng-Nan Huang, Xuan Jiang, Wen-Bo Zeng, Jin-Yan Sun, Fu-Kun Zhang, Hong-Jie Shen, Elizabeth Fortunato, Min-Hua Luo, Han Cheng
Summary: This study provides a comprehensive analysis of host cell protein expression changes during HCMV latency establishment and reactivation processes in neural cells. ApoE was found to be downregulated by HCMV to facilitate latent infection, and several PI3K pathway-related proteins were associated with HCMV reactivation. This research highlights potential druggable targets for HCMV-related diseases, especially brain disorders.
JOURNAL OF VIROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Rosalia Moreddu, Alessio Boschi, Marta d'Amora, Aliaksandr Hubarevich, Francesco De Angelis
Summary: Bioelectrical variations trigger a range of cellular responses and tissue-level phenomena. Monitoring these mechanisms is crucial in diagnostics and drug testing, but current technologies are invasive. The presented approach enables passive recording of electrical signals from non-excitable cells using 3D microelectrodes and optical mirroring. This technology shows promise in evaluating cell adhesion and proliferation, and could potentially provide quantitative data on surface charges and resting potential for studying electrical phenomena in cell migration and cancer progression.
Article
Chemistry, Inorganic & Nuclear
Sophie A. Fitzgerald, Ellie N. Payce, Peter N. Horton, Simon J. Coles, Simon J. A. Pope
Summary: This study describes the synthesis and characterisation of eleven different 2-(thienyl)quinoxaline species with various functionalities. These species exhibit variable fluorescence properties in the visible region and can serve as cyclometalating agents for Ir(III) to form luminescent complexes.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Encarnacion Fuster, Hector Candela, Jorge Estevez, Eugenio Vilanova, Miguel A. Sogorb
Summary: Exposure to titanium dioxide nanoparticles may potentially cause neuroinflammation and compromise the integrity of the blood brain barrier, while zinc oxide nanoparticles showed no significant effects. Additionally, titanium dioxide nanoparticles may have anticancer properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Qin Ai Wong, Ching Kheng Quah, Xin Ai Wong, Yip-Foo Win, Huey Chong Kwong, Parutagouda Shankaragouda Patil, Neelamma B. Gummagol, Venugopal S. Rao
Summary: The impact of the substitutional position on the non-linear optical response of chalcone derivatives is investigated in this study. Two synthesized compounds are studied experimentally and computationally to understand their optical properties and charge transfer mechanism. The compounds exhibit both positive and negative non-linearities, and the influence of medium and external field wavelength on their optical properties is analyzed.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Cornel Manuel Bachmann, Daniel Janitschke, Anna Andrea Lauer, Tobias Erhardt, Tobias Hartmann, Marcus Otto Walter Grimm, Heike Sabine Grimm
Summary: Gemfibrozil, a drug used for over 40 years to reduce triglycerides in blood, induces the transcription of genes for carbohydrate and lipid metabolism. However, little is known about its effects on intracellular lipid-homeostasis, specifically triglycerides. This study showed that gemfibrozil increased intracellular triglycerides in three different cell lines, suggesting enhanced cellular uptake. Furthermore, cell-line specific alterations in acylcarnitines were found, indicating increased transport of fatty acids to mitochondria, potentially important in diseases like Alzheimer's.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Yu-zhe Wang, De-hua Yang, Ming-wei Wang
Summary: In this study, a co-expression system of both GLP-1R and GIPR was constructed to study the signaling profiles elicited by mono, dual, and triple agonists. It was found that GIP predominantly induced cAMP accumulation while GLP-1 was biased towards beta-arrestin 2 recruitment when the two receptors were co-expressed, and the presence of GIPR negatively impacted GLP-1R-mediated responses. Dual agonists and a triple agonist displayed differentiated signaling profiles and negative impact on heteromerization, which may help interpret their superior clinical efficacies.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biophysics
V. P. Sangeetha, Sri Smriti, Pratima R. Solanki, P. Mohanan
Summary: The study revealed that at higher concentrations, zwitterionic carbon dots can affect cell viability and mitochondrial membrane potential, leading to apoptosis, with higher concentrations resulting in a higher percentage of apoptosis.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Cell Biology
Marilia Locatelli Correa-Ferreira, Amanda do Rocio Andrade Pires, Igor Resendes Barbosa, Aurea Echevarria, Guilherme Henrique Pedrassoli, Sheila Maria Brochado Winnischofer, Guilhermina Rodrigues Noleto, Silvia Maria Suter Correia Cadena
Summary: This study evaluated the cytotoxic effect of MI-D on T98G glioblastoma cells and found that MI-D exerts cytotoxicity by impairing mitochondrial oxidative phosphorylation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Shammy Raj, Lei Lu, Larry D. Unsworth
Summary: Identifying specific ligands for important cell receptors like MRGPRX2 is crucial for various applications, but screening large numbers of peptides for MRGPRX2 specificity is challenging due to the difficulty and cost of maintaining mast cells. This study demonstrates a method to design, develop, and screen a library of small peptide molecules using MRGPRX2-expressing HEK cells, which are easy and cost-effective to maintain for high-throughput analysis.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Biochemistry & Molecular Biology
Ana Da Silva Costa, Peter Mortensen, Maria P. Hortigon-Vinagre, Marcel A. G. van der Heyden, Francis L. Burton, Hao Gao, Radostin D. Simitev, Godfrey L. Smith
Summary: Co-culturing hiCMs with HEK cells expressing Kir2.1 at a 1:1 ratio can incorporate I-K1, reduce spontaneous rate and action potential duration, and lead to changes in electrical activity in the syncytium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Sandra Fusco, Mario Barra, Lorenzo Gontrani, Matteo Bonomo, Federico Chianese, Simone Galliano, Roberto Centore, Antonio Cassinese, Marilena Carbone, Antonio Carella
Summary: Three novel diketopyrrolopyrrole (DPP) based small molecules were synthesized and characterized in terms of their chemical-physical, electrochemical and electrical properties. The molecules have a central DPP electron acceptor core symmetrically functionalized with donor bi-thienyl moieties and flanked by three different auxiliary electron-acceptor groups. The molecular structure allows for significant absorption at longer wavelengths and has a narrow optical bandgap. Organic field-effect transistors (OFETs) were fabricated using the DPP dyes as active layers and showed different charge-transport properties depending on the end-functionalization. Additionally, well-balanced ambipolar transistors were achieved by blending the most performant n-type and p-type dyes.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Eva Schaller, Andi Ma, Lisa Chiara Gosch, Adrian Klefenz, David Schaller, Nils Goehringer, Leonard Kaps, Detlef Schuppan, Andrea Volkamer, Rainer Schobert, Bernhard Biersack, Bianca Nitzsche, Michael Hoepfner
Summary: The new 2-(thien-2-yl)-acrylonitrile derivatives showed promising antineoplastic efficacy in hepatoma models, with two derivatives identified as inhibitors with preferential activity against VEGFR-2 tyrosine kinase through kinase profiling. Their mode of action included inducing apoptotic capsase-3 activity in hepatoma cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Multidisciplinary Sciences
Neha Kaushik, Sarmistha Mitra, Eun Jung Baek, Linh Nhat Nguyen, Pradeep Bhartiya, June Hyun Kim, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: This review critically examines methods for generating reactive oxygen species (ROS) and explores their potential as a solution for virus deactivation. The study highlights the ability of ROS to directly eradicate pathogens through oxidative stress and indirectly through non-oxidative mechanisms. Additionally, the novel and environmentally friendly cold plasma delivery system for virus destruction is discussed in detail.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Environmental Sciences
Kien Tiek Wong, So Yeon Yoon, Seok Byum Jang, Nurhaslina Abd Rahman, Choe Earn Choong, Young June Hong, Sang-Eun Oh, Eun Ha Choi, Min Jang
Summary: Atmospheric non-thermal dielectric barrier discharge (DBD) plasma has been widely studied due to its cost-efficiency and environmental friendliness. However, its limitations have hindered its extensive application. In this study, the DBD plasma was used to degrade three pharmaceutically active compounds (PhACs), and the combination of plasma and electrolysis was found to be an effective approach for their removal. The production of NH3 as a by-product also adds value to the system.
Review
Environmental Sciences
Nidhi Deshwal, Madhur Babu Singh, Indra Bahadur, Neha Kaushik, Nagendra Kumar Kaushik, Prashant Singh, Kamlesh Kumari
Summary: Graphene oxide, a two-dimensional carbon nanomaterial, has gained significant popularity in the past decade due to its easy dispersion in water and extensive research in various fields. The unique chemical structure of graphene oxide, which includes hydrophilic functional groups and sp2 carbon domains, contributes to its exceptional properties and compatibility with various compounds. Its interactions with metal ions allow for their effective removal, making it a promising material for industrial-scale applications.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Biochemistry & Molecular Biology
Tabrez Faruqui, Mohd Sajid Khan, Yusuf Akhter, Salman Khan, Zeeshan Rafi, Mohd Saeed, Ihn Han, Eun-Ha Choi, Dharmendra Kumar Yadav
Summary: The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin family that is overexpressed in several cancers. RAGE serves as an important node for the initiation and stimulation of cell stress and growth signaling mechanisms that promote carcinogenesis, tumor propagation, and metastatic potential. Inhibiting the interaction of RAGE with its ligands could provide an effective strategy for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shweta B. Borkar, Manorma Negi, Neha Kaushik, Shaik Abdul Munnaf, Linh Nhat Nguyen, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: The proportion of resistant bacteria will increase over time, which is a major concern. Effective and biocompatible therapeutic strategies are urgently needed to combat these bacteria. Non-thermal plasma has been extensively studied for its antibacterial activity. This study investigates the inactivation efficiency and mechanisms of plasma-generated nitric oxide water (PG-NOW) on pathogenic Gram-negative and Gram-positive bacteria in water, air, soil, and food. Results showed that PG-NOW treatment effectively inhibits bacterial growth and accumulates nitric oxide within the cells. Gene expressions related to nitrosative stress and oxidative stress were also analyzed, supporting the nitrosative effect of PG-NOW. Additionally, changes in cell morphology were observed. These findings provide evidence for the further development of PG-NOW-based antibacterial treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Chemical
Ji Yoon Kim, Min Gyu Song, Eun Bi Jeon, Eun Ha Choi, Jun Sup Lim, Shin Young Park
Summary: We conducted a study on the antibacterial effect of dielectric barrier discharge plasma (DBDP) treatment on Escherichia coli and Vibrio parahaemolyticus on the surface of polypropylene plastic containers. DBDP treatment for 60 minutes showed a reduction of 1.65 log CFU/coupon (97.81% reduction) for E. coli, and a reduction of 6.81-6.13 log CFU/coupon for V. parahaemolyticus. The D-values were 26.5 and 61.2 minutes for E. coli and V. parahaemolyticus, respectively. The 60-minute DBDP treatment can be an eco-friendly sterilization method to remove over 90% of bacteria from PP plastic surfaces without any physical effect. Therefore, DBDP is suggested as a novel commercial sterilization strategy for pathogenic bacteria on polypropylene plastic surfaces.
JOURNAL OF FOOD ENGINEERING
(2023)
Review
Medicine, Research & Experimental
Adrija Sinha, Rahul Bhattacharjee, Basudha Bhattacharya, Aditya Nandi, Ramya Shekhar, Ankit Jana, Koustav Saha, Lamha Kumar, Swadheena Patro, Pritam Kumar Panda, Nagendra Kumar Kaushik, Mrutyunjay Suar, Suresh K. Verma
Summary: Short nucleotide sequences like miRNA and siRNA have gained significant attention in the field of oral-biome investigations. This review focuses on the application of miRNA in various oral health conditions and diseases, such as oral cancer, dental implants, periodontal diseases, etc. Additionally, the use of siRNA against these diseases is also discussed, along with the impact of miRNA and siRNA on dental diseases at a molecular level.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Manorma Negi, Neha Kaushik, Linh Nhat Nguyen, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: Cold atmospheric plasma-treated liquids (PTLs) have selective toxicity against tumor cells, mainly caused by reactive oxygen and nitrogen species in the liquids. Compared to the gaseous phase, these reactive species are more stable in the aqueous phase. This study aims to induce immunomodulation by plasma-treated Ringer's lactate (PT-RL) and phosphate-buffered saline (PT-PBS) solutions for cancer treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Rida Javed, Sohail Mumtaz, Eun Ha Choi, Ihn Han
Summary: Nonthermal biocompatible plasma (NBP) is a promising technology in agriculture for enhancing plant growth. Plasma serves as a source of reactive oxygen and nitrogen species (RONS) that activate signaling molecules in plant metabolism. However, the acidic pH of plasma-treated water (PTW) may be detrimental to pH-sensitive plants. Therefore, innovative techniques to neutralize the pH value of PTW to broaden the application of NBP in agriculture are urgently needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Physical
Elizaveta Demishkevich, Andrey Zyubin, Alexey Seteikin, Ilia Samusev, Inkyu Park, Chang Kwon Hwangbo, Eun Ha Choi, Geon Joon Lee
Summary: The purpose of this paper is to provide a comprehensive review of plasmonic metal nanoparticles made from rhodium, platinum, gold, or silver. The paper discusses fundamental concepts, synthesis methods, and optical sensing applications of these nanoparticles. Plasmonic metal nanoparticles have gained significant interest due to their potential for highly sensitive detection of analytes in various fields.
Article
Materials Science, Multidisciplinary
Amir Muhammad Afzal, Muhammad Waqas Iqbal, Muhammad Imran, Humaira Umair, Saikh Mohammad Wabaidur, Essam A. Al-Ammar, Sohail Mumtaz, Eun Ha Choi
Summary: This research synthesized a cobalt niobium sulfide@polyaniline (CoNbS@PANI) composite using the hydrothermal method and studied its structural and electrochemical characteristics. The CoNbS@PANI composite showed an improved specific capacity of 1207.5 C g(-1) due to the large conductivity and redox-active sites provided by PANI. The performance of activated carbon (AC) was enhanced by doping with PANI and used as an electrode in a hybrid device. A supercapattery device (CoNbS@PANI//PANI@AC) was designed, which exhibited an excellent specific capacity of 185 C g(-1) at 3 A g(-1).
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Apurva Jaiswal, Neha Kaushik, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: Despite recent advances in cancer therapy, triple-negative breast cancers (TNBCs) continue to be the most relapsing cancer subtype due to their propensity to develop resistance against available therapies. Non-coding RNAs (ncRNAs) have emerged as critical regulators of cancer hallmarks, and aberrant expression of ncRNAs can modulate oncogenic or tumor suppressive signaling, thereby reducing responsiveness to anti-tumor interventions. This review provides a systematic overview of ncRNA biogenesis and downstream molecular mechanisms, as well as ncRNA-based strategies and challenges for targeting chemo-, radio-, and immunoresistance in TNBCs from a clinical perspective.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Engineering, Environmental
Seok Byum Jang, So Yeon Yoon, Kien Tiek Wong, Choe Earn Choong, Yeomin Yoon, Eun Ha Choi, Min Jang
Summary: A highly efficient rigid floatable photocatalyst was prepared by seeding ZnO in polyurethane (PU) and subsequent hydrothermal ZnO coating (P-ZsZc). The photocorrosion resistance of the P-ZsZc photocatalyst was significantly enhanced due to the uplifted valence band and the formation of new covalent Zn-O-C bond. The P-ZsZc exhibited excellent removal of sulfamethoxazole (SMX) and constant SMX removal in continuous flow experiments.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Biotechnology & Applied Microbiology
Himani Singh, Niharika, Pradeep Lamichhane, Ravi Gupta, Neha Kaushik, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: Pesticides have been widely used in modern agriculture to ensure good harvests, but their excessive use has caused significant environmental degradation and toxicity to non-target organisms. Plants have developed mechanisms, such as the production of secondary metabolites, to reduce the toxicity of pesticides. Recent studies have highlighted the potential role of plasma technology in mitigating environmental stresses.
PLANT BIOTECHNOLOGY REPORTS
(2023)
Article
Engineering, Biomedical
Nagendra Kumar Kaushik, Pradeep Bhartiya, Neha Kaushik, Yungoh Shin, Linh Nhat Nguyen, Jang Sick Park, Doyoung Kim, Eun Ha Choi
Summary: This study demonstrates that nitric oxide enriched plasma-activated water (NO-PAW), generated by a microwave plasma system, effectively inhibits coronavirus infection in host lung cells and improves host antiviral responses.
BIOACTIVE MATERIALS
(2023)
