Article
Biochemistry & Molecular Biology
Feifei Wang, Jie Tan, Ruixiang Jiang, Feifei Li, Renqing Zheng, Linjun Yu, Lianzhong Luo, Yongbiao Zheng
Summary: In recent years, the cultivation of wild morel mushroom species has become popular in China due to their high value in terms of edibility and medicinal properties. This study used liquid-submerged fermentation to investigate the secondary metabolites of Morehella importuna and identified several new and known compounds with significant antioxidant activity. These findings shed light on the medicinal value of M. importuna and its potential as a rich source of antioxidants.
Article
Chemistry, Applied
Jing Wang, Xiao-Qian Wu, Ji-Song Mo, Yu-Fen Tan, Hong-Ping Long, Si-Qian Zhou, Shao Liu, Jing Li, Wen-Xuan Wang
Summary: Two pairs of new isobenzofuranone derivative enantiomers, (+/-)-penicifurans E (1) and (+/-)-penicifurans F (2), along with four known compounds (3-6), were discovered from the solid fermentation of Penicillium canescens DWS225. Their structures were determined through extensive NMR spectroscopic analysis, and their absolute configurations were confirmed by experimental and calculated ECD data. Furthermore, the neuroprotective effects of all the isolated compounds against oxygen-glucose deprivation/reperfusion injury in PC12 cells were investigated.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Bingyuan Zhang, Yan Tang, Zhe Guo, Jun Hu, Qingrong Du, Tao Zhang, Shengjun Dai, Baiping Ma, Liyan Yu, Dewu Zhang
Summary: A new isobenzofuranone derivative and six known compounds were isolated from Arctic fungus Gyoerffyella sp. CPCC 401434, and their structures and absolute configurations were determined. This is the first report of these compounds from the genus Gyoerffyella, and their cytotoxic and antibacterial activities were also studied.
RECORDS OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Zoltan Beni, Miklos Dekany, Andras Sarkozy, Annamaria Kincses, Gabriella Spengler, Viktor Papp, Judit Hohmann, Attila Vanyolos
Summary: Investigation of the poroid fungus Fuscoporia torulosa led to the isolation of a novel triterpene fuscoporic acid, along with other compounds with antibacterial and cytotoxic properties. Some compounds exhibited antioxidant activity, while none showed P-glycoprotein modulatory effect in resistant cancer cells.
Article
Biochemistry & Molecular Biology
Anbazhagan Sathiyaseelan, Kandasamy Saravanakumar, Arokia Vijaya Anand Mariadoss, Kristine M. Kim, Myeong-Hyeon Wang
Summary: Endophytic fungi, such as Paraconiothyrium brasiliense, are rich sources of bioactive metabolites with potential biomedical applications. This study isolated PB from Capsicum annuum fruit and evaluated its biochemical, antimicrobial, antioxidant, cell viability, and cytotoxicity properties. Results showed that PB-EAE exhibited significant antioxidant and antimicrobial activities, while GC-MS analysis confirmed the presence of various volatile molecules. Molecular docking analysis also demonstrated significant interactions between compounds in PB-EAE and the target protein DHPS. This study suggests that endophytic P. brasiliense could be a valuable source of antimicrobials.
PROCESS BIOCHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Yifan Sun, Guangxi Ren, Qijin Shi, Hongyu Zhu, Na Zhou, Xianghe Kong, Dan Jiang, Chunsheng Liu
Summary: In this study, F. oxysporum GU-7 and GU-60 were isolated from Glycyrrhiza uralensis, and their antioxidant activities were found to be significantly different. Metabolomics analysis identified abundant dipeptides, phenolic acids, and plant-derived coumarins in GU-7, which may account for its stronger antioxidant activity compared to GU-60. The study also identified key genes and intermediate metabolites involved in coumarin biosynthesis.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nawasit Chotsaeng
Summary: Thirty-five ketone-isobenzofuranone hybrids were synthesized and evaluated for their herbicidal activity. The location and type of substituent were found to be crucial for activity, with o-substituted derivatives performing better than m- and p-substituted derivatives. Compounds with strong electron-donating groups had low activity, while those with heterocycles showed moderate herbicidal effects. Compounds with weak electron-donating groups and electron-withdrawing groups showed promising herbicidal activity, with o-F substituted compound being the most effective against Chinese amaranth and o-Cl substituted compound being the most potent against barnyard grass.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Plant Sciences
Weili Chen, Tao Ye, Qinyu Sun, Tingting Niu, Jiaxia Zhang
Summary: Tea plants are affected by biotic stress and extreme weather, which can reduce yield and quality. Anthracnose, a common and serious disease, has gained attention as its control relies on chemical pesticides. This study investigates the impact of arbuscular mycorrhizal fungi (AMF) on anthracnose development in tea plants and identifies relevant mechanisms through transcriptome analysis. Results show that AMF inoculation significantly reduces anthracnose damage on tea seedlings and increases the antioxidant system's activity, suggesting the potential use of AMF as a biological control method in tea plantations.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Chemistry, Organic
Gong Tingting, Chen Zhibin, Liu Miaochang, Cheng Jiang
Summary: This paper summarizes the research on the synthesis of isobenzofuranones in recent ten years from three aspects: transition metal catalytic synthesis, acid-base catalytic synthesis, and other synthesis methods.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Food Science & Technology
Talita C. E. S. Nascimento, Joao Vitor Dutra Molino, Priscila R. S. Donado, Gualberto S. A. Montalvo, Wellington L. dos Santos, Jose Erick G. Gomes, Joao H. P. M. Santos, Roberto da Silva, Lara Duraes Sette, Adalberto Pessoa Junior, Keila Aparecida Moreira
Summary: The extracellular serine protease produced by Acremonium sp. L1-4B isolated from the Antarctic continent was used to hydrolyze bovine and caprine sodium caseinate, resulting in protein hydrolysates with antioxidant and antihypertensive potential. Mass spectrometry characterization revealed differences in peptide sequences between the bovine and caprine hydrolysates, indicating the potential for developing new functional foods and nutraceutical formulations.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Patricia P. Adriani, Fernanda C. R. de Paiva, Gabriel S. de Oliveira, Amanda C. Leite, Adriana S. Sanches, Adriana Rios Lopes, Marcio V. B. Dias, Felipe S. Chambergo
Summary: The study characterized the functional and structural features of a glutathione peroxidase (GPx) identified in Trichoderma reesei, demonstrating that TrGPx is a thioredoxin peroxidase with better hydrolysis activity towards H2O2 than t-BOOH. Additionally, TrGPx showed optimal pH range and half-life at 80 degrees Celsius.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Dan Li, David Mahoudjro Bodjrenou, Shuting Zhang, Bin Wang, Hong Pan, Kai-Wun Yeh, Zhongxiong Lai, Chunzhen Cheng
Summary: The study showed that Piriformospora indica colonization can enhance cold resistance in bananas by reducing oxidative damage, increasing antioxidant enzyme activity, soluble sugar accumulation, and the expression of cold-responsive genes in leaves. Additionally, P. indica colonization improved photosynthetic efficiency and electron transport rate in banana leaves under cold stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Veronica Albornoz, Virginia Casas-Arrojo, Fabian Figueroa, Cristian Riquelme, Victor Hernandez, Mario Rajchenberg, Carlos T. Smith, Victor L. Campos, Roberto T. Abdala-Diaz, Jose Becerra, Claudia Perez, Jaime R. Cabrera-Pardo
Summary: The study evaluated the cytotoxic and antioxidant activity of the acidic polysaccharides of Phylloporia boldo strain in tumor cells, demonstrating its toxic effects on tumor cells and antioxidant properties.
NATURAL PRODUCT RESEARCH
(2022)
Article
Environmental Sciences
Vellingiri Manon Mani, Sethumathavan Kalaivani, Shanmugam Sabarathinam, Manikandan Vasuki, Arockiam Jeyasundar Parimala Gnana Soundari, M. P. Ayyappa Das, Ashraf Elfasakhany, Arivalagan Pugazhendhi
Summary: The study focused on synthesizing Copper Oxide Nanoparticles (CuONPs) using an endophytic fungus isolated from a medicinal tree in India, and evaluated their antibacterial, antifungal, antioxidant, and anti-cancer activities. The CuONPs exhibited significant anti-cancer effects on colon cancer cell lines and angiogenesis inhibition in tumor cells in a concentration-dependent manner, highlighting their potential in cancer therapeutics.
ENVIRONMENTAL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Yanjiang Zhang, Hongxin Liu, Yuchan Chen, Zhaoming Liu, Kaidi Qiu, Shanshan Wei, Weimin Zhang, Haibo Tan
Summary: In this study, two new alkylresorcinols and four known compounds were isolated from the endophytic fungus Cytospora rhizophorae A761. The structures of the new compounds were determined using various spectroscopic techniques. Compound 1 exhibited potent inhibitory activity against alpha-glucosidase, while compound 2 showed good activity against tumor cell lines. Additionally, it was found that compound integracin B exhibited significant antibacterial activity against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA).
JOURNAL OF ANTIBIOTICS
(2023)
