Article
Cell Biology
Ajit Roy, Arup R. Chakraborty, Tyzoon Nomanbhoy, Melvin L. DePamphilis
Summary: Although the selectivity of PIKFYVE phosphoinositide kinase inhibitors in eliminating PIKFYVE-dependent human cancer cells has been observed, the specific mechanism has been unclear. This study found that the sensitivity of cells to the PIKFYVE inhibitor WX8 is not related to PIKFYVE expression, cellular processes, or the BRAF(V600E) mutation. Instead, it is due to a deficiency in the PIP5K1C phosphoinositide kinase, which is involved in lysosome homeostasis, endosome trafficking, and autophagy. The results suggest that PIKFYVE-dependent cancers can be identified by low levels of PIP5K1C and targeted with PIKFYVE inhibitors.
Article
Chemistry, Multidisciplinary
Rosalia Moreddu, Alessio Boschi, Marta d'Amora, Aliaksandr Hubarevich, Francesco De Angelis
Summary: Bioelectrical variations trigger a range of cellular responses and tissue-level phenomena. Monitoring these mechanisms is crucial in diagnostics and drug testing, but current technologies are invasive. The presented approach enables passive recording of electrical signals from non-excitable cells using 3D microelectrodes and optical mirroring. This technology shows promise in evaluating cell adhesion and proliferation, and could potentially provide quantitative data on surface charges and resting potential for studying electrical phenomena in cell migration and cancer progression.
Article
Chemistry, Multidisciplinary
Duoling Cao, Zuhong Li, Wenbo Li, Ke Pei, Xu Zhang, Li Wan, Li Zhao, Alexey Cherevan, Dominik Eder, Shimin Wang
Summary: Carbon counter electrode-based perovskite solar cells (C-PSCs) are considered promising due to their stability and low cost. This study used two novel pheniramine halides to modify the interface between the electron transport layer and perovskite layer, resulting in improved device performance. The modified C-PSCs achieved higher power conversion efficiency compared to the control device, and the unencapsulated modified device maintained a high level of its initial efficiency under ambient conditions for 800 hours. This study suggests the potential application of multifunctional complex molecules in high-efficiency and stable C-PSCs.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Polymer Science
Biao Zhang, Guillaume Sudre, Guilhem Quintard, Anatoli Serghei, Julien Bernard, Etienne Fleury, Aurelia Charlot
Summary: This study mixed RAFT-made poly(ionic liquid) chains with an ionic liquid, leading to homogeneous and transparent solutions due to similarities in structure and polarity. Rheology investigation showed that the solution's viscoelastic properties can be finely tuned by adjusting the chain molar mass and concentration. The high ionic conductivity and multi-scale local homogeneity of the PIL/IL solutions were confirmed through X-ray scattering experiments and microscopy analysis.
Article
Oncology
Corey Neff, Mackenzie Price, Gino Cioffi, Carol Kruchko, Kristin A. Waite, Jill S. Barnholtz-Sloan, Quinn T. Ostrom
Summary: This study estimates the prevalence of malignant and non-malignant brain tumors in comparison to other cancers. The results show that brain tumors contribute significantly to the cancer burden in the United States, especially among those younger than age 65 years. Understanding complete prevalence is crucial for monitoring cancer burden, informing clinical research, and guiding public policy.
Article
Chemistry, Physical
Ksenia S. Egorova, Marina M. Seitkalieva, Alexey S. Kashin, Evgeniy G. Gordeev, Anna V. Vavina, Alexandra V. Posvyatenko, Valentine P. Ananikov
Summary: This study investigated the cytotoxicity of chemically relevant imidazolium PILs with different alkyl side chains and compared it with aprotic analogues. The results highlighted the role of anion type in determining the cytotoxicity of ILs with short alkyl side chains. Even low-toxic PILs showed harmful effects on eukaryotic cells when used as cryopreservation agents, and the studied IL/water mixtures tended to form simple solid hydrates due to the weak amphiphilic properties of imidazolium cations with short alkyl side chains.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Physical
Aili Wang, Xiaoyu Deng, Jianwei Wang, Shurong Wang, Xiaobin Niu, Feng Hao, Liming Ding
Summary: The use of the ionic liquid BMIMBF4 can stabilize the CsPbI2Br phase and reduce surface defect density, leading to improvements in perovskite film quality and interfacial charge transport.
Article
Genetics & Heredity
Yiyan Songyang, Tianbao Song, Zhan Shi, Wen Li, Songyisha Yang, Dejia Li
Summary: Vitamin D inhibits the proliferation, invasion, and metastasis of NSCLC cells A549 and NCI-H1975, promoting cell apoptosis and increasing sensitivity to chemotherapy drugs. These effects may be correlated with the PI3K/AKT/mTOR signaling pathway.
Article
Biochemistry & Molecular Biology
Jordan D. Herod, Duncan W. Bruce
Summary: The study examines families of symmetric, ionic, tetracatenar mesogens based on a rigid N-phenylpyridinium core, prepared with various terminal chain lengths for different salts. Different families exhibit distinct phase transition behaviors, such as SmA phase, Col(h) phase, and intermediate cubic phase.
Article
Chemistry, Physical
Wen Wu, Min Fang, Lingfeng Chao, Lei Tao, Hui Lu, Bixin Li, Xueqin Ran, Ping Li, Yingdong Xia, Hui Zhang, Yonghua Chen
Summary: A novel route to accelerate nucleation via in situ nanocrystal seeding crystallization was proposed in this study. High-quality perovskite thin films were obtained with reduced defect density and shallowed trap depth by incorporating excess PbCl2 and generating MAPbCl(3-x)Ac(x) nanocrystals as nuclei to regulate perovskite growth. This method resulted in significantly enhanced VOC in corresponding solar cells, with a champion device achieving efficiency up to 21.26% and improved storage stability for more than 1300 hours.
MATERIALS TODAY ENERGY
(2021)
Editorial Material
Cell & Tissue Engineering
Shayan Saniei, Elvin Wagenblast
Summary: Engineered hematopoietic stem cells with altered epitopes can avoid targeted immunotherapy, according to a recent study published in Nature.
Article
Polymer Science
Florian Wanghofer, Archim Wolfberger, Markus Wolfahrt, Sandra Schloegl
Summary: Poly(ionic liquids) (PILs) and ionenes are polymers with ionic groups in their repeating units, offering unique properties for various applications. Literature reports numerous synthesis protocols for task-specific PILs with different functional groups. Epoxy chemistry shows potential for tailorable PIL networks, where suitable hardeners can vary the glass transition onset temperature of the networks.
Article
Nanoscience & Nanotechnology
Xiongwei Liu, Kuizhong Shan, Xiaxia Shao, Xianqing Shi, Yun He, Zhen Liu, Joe Antony Jacob, Lichun Deng
Summary: The biomimetic approach of synthesizing silver nanoparticles using Rhizophora apiculata leaf extract showed dose-dependent cytotoxic effects on HEK-293 and HeLa cells, being three times more toxic to HEK-293 cells compared to HeLa cells.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Monia A. R. Martins, Liliana P. Silva, Patricia S. Jorge, Dinis O. Abranches, Simao P. Pinho, Joao A. P. Coutinho
Summary: New eutectic mixtures were developed for drug pre-formulation, with thymol showing strong interactions with active pharmaceutical ingredients and promoting liquefaction. The Conductor-like Screening Model for Real Solvents (COSMO-RS) was found to be a useful tool for predicting the solid-liquid equilibrium of mixtures containing non-ionic excipients.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Andres-Felipe Villamizar-Mogotocoro, Sandra-Milena Bonilla-Castaneda, Vladimir V. Kouznetsov
Summary: An ecofriendly and efficient method for the synthesis of new pharmacologically active 6-arylphenanthridines has been developed using inexpensive starting materials and consecutive reactions under microwave assistance and a catalytic system, resulting in moderate to excellent yields.
Review
Multidisciplinary Sciences
Neha Kaushik, Sarmistha Mitra, Eun Jung Baek, Linh Nhat Nguyen, Pradeep Bhartiya, June Hyun Kim, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: This review critically examines methods for generating reactive oxygen species (ROS) and explores their potential as a solution for virus deactivation. The study highlights the ability of ROS to directly eradicate pathogens through oxidative stress and indirectly through non-oxidative mechanisms. Additionally, the novel and environmentally friendly cold plasma delivery system for virus destruction is discussed in detail.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Engineering, Environmental
Choe Earn Choong, So Yeon Yoon, Minhee Kim, Gooyong Lee, Sang-Hyoun Kim, Byong-Hun Jeon, Jaeyoung Choi, Yeomin Yoon, Eun Ha Choi, Min Jang
Summary: Hydrophobic sulfur (S) core-shell-layered nano-zero-valent iron (Fe) (S-nZVI) was prepared for NO3- reduction using a post-sulfidation method with varying Fe/S mass ratios. S(0.125)ZVI (Fe/S = 0.125) showed good N-O cleavage properties due to high electron transfer efficiency and low surface passivation. It exhibited higher selectivity of NO3- reduction toward N-2 than sole nZVI in synthetic and actual NO3- groundwater.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Environmental Sciences
Kien Tiek Wong, So Yeon Yoon, Seok Byum Jang, Nurhaslina Abd Rahman, Choe Earn Choong, Young June Hong, Sang-Eun Oh, Eun Ha Choi, Min Jang
Summary: Atmospheric non-thermal dielectric barrier discharge (DBD) plasma has been widely studied due to its cost-efficiency and environmental friendliness. However, its limitations have hindered its extensive application. In this study, the DBD plasma was used to degrade three pharmaceutically active compounds (PhACs), and the combination of plasma and electrolysis was found to be an effective approach for their removal. The production of NH3 as a by-product also adds value to the system.
Review
Biochemistry & Molecular Biology
Tabrez Faruqui, Mohd Sajid Khan, Yusuf Akhter, Salman Khan, Zeeshan Rafi, Mohd Saeed, Ihn Han, Eun-Ha Choi, Dharmendra Kumar Yadav
Summary: The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin family that is overexpressed in several cancers. RAGE serves as an important node for the initiation and stimulation of cell stress and growth signaling mechanisms that promote carcinogenesis, tumor propagation, and metastatic potential. Inhibiting the interaction of RAGE with its ligands could provide an effective strategy for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shweta B. Borkar, Manorma Negi, Neha Kaushik, Shaik Abdul Munnaf, Linh Nhat Nguyen, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: The proportion of resistant bacteria will increase over time, which is a major concern. Effective and biocompatible therapeutic strategies are urgently needed to combat these bacteria. Non-thermal plasma has been extensively studied for its antibacterial activity. This study investigates the inactivation efficiency and mechanisms of plasma-generated nitric oxide water (PG-NOW) on pathogenic Gram-negative and Gram-positive bacteria in water, air, soil, and food. Results showed that PG-NOW treatment effectively inhibits bacterial growth and accumulates nitric oxide within the cells. Gene expressions related to nitrosative stress and oxidative stress were also analyzed, supporting the nitrosative effect of PG-NOW. Additionally, changes in cell morphology were observed. These findings provide evidence for the further development of PG-NOW-based antibacterial treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Afza Ahmad, Rohit Kumar Tiwari, Mohd Saeed, Hadba Al-Amrah, Ihn Han, Eun-Ha Choi, Dharmendra K. K. Yadav, Irfan Ahmad Ansari
Summary: In recent times, there has been a significant increase in focusing on the hedgehog (HH)/GLI signaling pathway as a therapeutic target for cervical cancer. The HH pathway is known to play a critical role in the development of cervical cancer and is also associated with recurrence and chemoresistance. Carvacrol (CAR) has previously been shown to inhibit proliferation in prostate cancer cells by targeting the Notch signaling pathway, making it a rational choice to study its antiproliferative effects in cervical cancer cells. This study aimed to investigate the anticancer and apoptotic potential of CAR in C33A cervical cancer cells and explore the underlying mechanisms.
FRONTIERS IN CHEMISTRY
(2023)
Article
Engineering, Environmental
Shaik Abdul Munnaf, Jun Sup Lim, Janardhan Reddy Koduru, Eun Ha Choi
Summary: In this study, non-thermal plasma discharge was used to potentially remove As(III) in contaminated water, achieving enhanced redox adsorption. Reactive species generated by plasma-water interaction were utilized to transform As(III) to As(V) and modify the surface of the adsorbent, MnOFe2O3. The catalytic adsorption ability of the adsorbent was improved by 30% via the redox adsorptive mechanism. Batch kinetics and isotherm studies demonstrated the effectiveness of the adsorption process, and the adsorption yield was estimated through surface analysis techniques.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Review
Environmental Sciences
Paritosh Patel, Aditya Nandi, Suresh K. Verma, Neha Kaushik, Mrutyunjay Suar, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: Emerging bio-contaminants, such as viruses, have had a significant impact on the health and environment of countries worldwide. Understanding the behavior of viruses is crucial in developing targeted therapeutic and vaccination treatments. Animal models, including non-human primates, rodents, and rabbits, offer advantages in assessing the risks of viral infections and chemical toxins, but their maintenance and experimental redundancy are issues. Therefore, exploring alternative animal models, such as zebrafish, is important. This review focuses on zebrafish traits and their potential in monitoring emerging bio-contaminants, particularly viruses like coronaviridae and poxviridae.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Electrical & Electronic
Tirtha Raj Acharya, Dinesh Kumar Chaudhary, Sandhya Gautam, Amrendra Kumar Singh, Rajesh Shrestha, Bishwa Chandra Adhikari, Prajwal Lamichhane, Bhupal Paudyal, Nagendra Kumar Kaushik, Eun Ha Choi
Summary: Thin films of zinc oxide (ZnO) were deposited on glass substrates using chemical bath deposition (CBD) with varied deposition time. The properties and formaldehyde gas responsiveness of the ZnO films were studied in relation to nanoparticle grain sizes. The results showed that longer deposition duration with larger grains led to higher gas response at room temperature. The ZnO films deposited for 1, 2, and 3 h exhibited maximum responses of 5.5, 11.0, and 17.8, respectively, at 400 ppm formaldehyde gas. Additionally, the films could detect as low as 100, 25, and 12 ppm of formaldehyde, respectively.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Review
Biochemistry & Molecular Biology
Apurva Jaiswal, Neha Kaushik, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: Despite recent advances in cancer therapy, triple-negative breast cancers (TNBCs) continue to be the most relapsing cancer subtype due to their propensity to develop resistance against available therapies. Non-coding RNAs (ncRNAs) have emerged as critical regulators of cancer hallmarks, and aberrant expression of ncRNAs can modulate oncogenic or tumor suppressive signaling, thereby reducing responsiveness to anti-tumor interventions. This review provides a systematic overview of ncRNA biogenesis and downstream molecular mechanisms, as well as ncRNA-based strategies and challenges for targeting chemo-, radio-, and immunoresistance in TNBCs from a clinical perspective.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Physics, Applied
Prajwal Lamichhane, Tirtha R. Acharya, Jaewoo Park, Kirubel A. Amsalu, Byoungchoo Park, Eun Ha Choi
Summary: This study investigates the effects of nonthermal plasma characteristics on surface treatments of polyvinyl alcohol. Various diagnostics, such as Raman spectroscopy, work of adhesion, optical emission spectroscopy, and current-voltage measurements, were used. The findings highlight the importance of controlling the plasma's electron temperature and density to achieve desired surface treatment outcomes. Plasma jets with varying electron temperatures are found to be more suitable for different surface treatments, with high electron temperatures (>1.1 eV) suitable for functional group insertion and low electron temperatures for plasma etching, which increases surface roughness significantly.
PLASMA PROCESSES AND POLYMERS
(2023)
Article
Chemistry, Physical
Muhammad Ali, Amir Muhammad Afzal, Muhammad Waqas Iqbal, Asad Ur Rehman, Saikh Mohammad Wabaidur, Essam A. Al-Ammar, Sohail Mumtaz, Eun Ha Choi
Summary: In this study, rGO and CoMnS nanostructures were synthesized and their structural and electrochemical properties were measured. The rGO@CoMnS composite electrode material showed a superior specific capacity of 1355.8 C/g compared to the reference electrode (747.6 C/g) in a 3-electrode measurement system. The estimated specific capacitance was 2238 F/g. This study provides new opportunities for designing high-performance energy devices.
Review
Biotechnology & Applied Microbiology
Himani Singh, Niharika, Pradeep Lamichhane, Ravi Gupta, Neha Kaushik, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: Pesticides have been widely used in modern agriculture to ensure good harvests, but their excessive use has caused significant environmental degradation and toxicity to non-target organisms. Plants have developed mechanisms, such as the production of secondary metabolites, to reduce the toxicity of pesticides. Recent studies have highlighted the potential role of plasma technology in mitigating environmental stresses.
PLANT BIOTECHNOLOGY REPORTS
(2023)
Article
Engineering, Biomedical
Nagendra Kumar Kaushik, Pradeep Bhartiya, Neha Kaushik, Yungoh Shin, Linh Nhat Nguyen, Jang Sick Park, Doyoung Kim, Eun Ha Choi
Summary: This study demonstrates that nitric oxide enriched plasma-activated water (NO-PAW), generated by a microwave plasma system, effectively inhibits coronavirus infection in host lung cells and improves host antiviral responses.
BIOACTIVE MATERIALS
(2023)
