Journal
MOLECULES
Volume 17, Issue 12, Pages 14685-14699Publisher
MDPI
DOI: 10.3390/molecules171214685
Keywords
multicomponent Ugi-type reaction; intramolecular Michael addition; 2,5-diketopiperazines; anti-proliferative effects
Funding
- DFG (Clinical Research Unit 216)
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The well-known Ugi reaction of aldehydes with amines, carboxylic acids and isocyanides leads to the formation of acyclic alpha-acylaminocarboxamides. Replacement of the carboxylic acid derivatives with beta-acyl substituted acrylic acids gives access to highly substituted 2,5-diketopiperazines in one single reaction-step without additives or complex reaction procedures. The obtained diketopiperazines show anti-proliferative effects on activated T cells and represent therefore potential candidates for targeting unwanted T cell-mediated immune responses.
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