Article
Microbiology
Fidelia Ijeoma Uche, Xiaozhen Guo, Jude Okokon, Imran Ullah, Paul Horrocks, Joshua Boateng, Chenggang Huang, Wen-Wu Li
Summary: This study investigates the in vitro and in vivo antiplasmodial activities of BBIQ alkaloids and their analogues, showing promising results with significant anti-parasitic effects at low concentrations. Cycleanine and its semisynthetic analogues demonstrate improved potency and selectivity, with potential as leads for further drug development.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Brodie L. Bailey, William Nguyen, Anna Ngo, Christopher D. Goodman, Maria R. Gancheva, Paola Favuzza, Laura M. Sanz, Francisco-Javier Gamo, Kym N. Lowes, Geoffrey I. McFadden, Danny W. Wilson, Benoit Laleu, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs
Summary: The study identified a triazolopyrimidine compound with good activity against Plasmodium falciparum and high selectivity against human cells, but faced challenges such as slow onset of action and low aqueous solubility. Further optimization is needed for its development as a potential partner in anti-malarial treatment.
BIOORGANIC CHEMISTRY
(2021)
Article
Biology
Oluwole Solomon Oladeji, Abimbola Peter Oluyori, Adewumi Oluwasogo Dada
Summary: Morinda lucida, a plant traditionally used to treat malaria in Nigeria, has shown antiplasmodial properties in this study. The leaves and bark of Morinda lucida could be potential sources for developing effective antimalarial drugs.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Chemistry, Medicinal
Preeti Kushwaha, Vipin Kumar, Biswajit Saha
Summary: beta-Carboline alkaloids are important nitrogen-based natural alkaloids and therapeutic molecules that exhibit various pharmacological activities through diverse mechanisms. There has been increasing attention towards developing effective antimalarial drugs based on this compound. This article comprehensively reviews the clinical and preclinical antimalarial scaffolds containing beta-carboline structure. The study focuses on the natural and semi-synthetic analogues of beta-carbolines reported in the last decade (2011-2021), providing insights into their mechanisms of action and potential for future therapeutic development.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Prisca Lagardere, Romain Mustiere, Nadia Amanzougaghene, Sebastien Hutter, Jean-Francois Franetich, Nadine Azas, Patrice Vanelle, Pierre Verhaeghe, Nicolas Primas, Dominique Mazier, Nicolas Masurier, Vincent Lisowski
Summary: Malaria remains a major global health problem, and the development of drug resistance poses a challenge. A series of 4-substituted thieno[3,2-d]pyrimidines were found to exhibit activity against different stages of the malaria parasite, with the chloro analogue of Gamhepathiopine showing promising activity against both the erythrocytic and hepatic stages.
Article
Biochemistry & Molecular Biology
Rogers J. Nyamwihura, Huaisheng Zhang, Jasmine T. Collins, Olamide Crown, Ifedayo Victor Ogungbe
Summary: The study focused on investigating nopol-based quinoline derivatives for their inhibitory activity against Plasmodium falciparum, one of the parasites that cause malaria. The results showed that certain derivatives were moderately active against the asexual blood stage of the parasite but inactive against chloroquine-resistant strains. Future research will focus on exploring the moderately active and selective compounds against different stages of Plasmodium parasites.
Article
Multidisciplinary Sciences
Arne Alder, Cecilia P. Sanchez, Matthew R. G. Russell, Lucy M. Collinson, Michael Lanzer, Michael J. Blackman, Tim-Wolf Gilberger, Joachim M. Matz
Summary: Malaria parasites use a complex to acidify the digestive vacuole and degrade host erythrocyte hemoglobin, which is essential for their survival in the human bloodstream.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Plant Sciences
Gervais Mouthe Happi, Pamela Kemda Nangmo, Liliane Clotide Dzouemo, Sorelle Fotsing Kache, Ariane Dolly Kenmogne Kouam, Jean Duplex Wansi
Summary: Meliaceae plants are important herbal sources for treating malaria in traditional African medicine. Studies have found significant antiplasmodial and insecticidal activities in this plant family, suggesting their potential as eco-friendly pesticides.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Douglas O. Ochora, Esezah K. Kakudidi, Jane Namukobe, Perpetua Ipulet, Dancan M. Wakoli, Winnie Okore, Edwin W. Mwakio, Redempthah A. Yeda, Agnes C. Cheruiyot, Dennis W. Juma, Ben Andagalu, Amanda L. Roth, Bernhards R. Ogutu, Abiy Yenesew, Hoseah M. Akala
Summary: Synergy was observed when extracts of Securidaca longipedunculata were combined with artemether and lumefantrine, showing potential in combating drug resistance in malaria treatment.
Article
Microbiology
Heather J. Painter, Joanne M. Morrisey, Michael W. Mather, Lindsey M. Orchard, Cuyler Luck, Martin J. Smilkstein, Michael K. Riscoe, Akhil B. Vaidya, Manuel Llinas
Summary: The emergence of drug-resistant Plasmodium falciparum parasites poses a challenge to global malaria eradication efforts, highlighting the importance of identifying new antimalarial drugs. Studying the molecular mechanism of drug resistance has revealed a novel resistance mechanism that could potentially guide the development of future antimalarial combination therapies.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Geeta Kumari, Ravi Jain, Kumar Sah, Inderjeet Kalia, Manu Vashistha, Pooja Singh, Agam Prasad Singh, Kirandeep Samby, Jeremy Burrows, Shailja Singh
Summary: The development of resistance to current antimalarial therapies is a major concern. In this study, the antimalarial activity of Tubulin targeting compounds against P. falciparum was evaluated. The compounds showed multistage antimalarial effects and potential transmission-blocking activity. Target mining implicated PfTubulin as their molecular target. These compounds have potential for further development as next-generation antimalarial agents.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Lekkala Ravindar, Siti Aishah Hasbullah, K. P. Rakesh, Nurul Izzaty Hassan
Summary: Malaria is a deadly parasitic infection ranked as the fifth most lethal worldwide. Antimalarial medications are crucial for preventing and eradicating malaria. The 4-aminoquinoline moiety has diverse biological applications and has been favored in antimalarial drug discovery. This review focuses on its efficacy when hybridized with various heterocyclic scaffolds, aiding the development of more effective antimalarial agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Microbiology
James S. McCarthy, Azrin N. Abd-Rahman, Katharine A. Collins, Louise Marquart, Paul Griffin, Anne Kummel, Aline Fuchs, Cornelis Winnips, Vishal Mishra, Katalin Csermak-Renner, J. Prakash Jain, Preetam Gandhi
Summary: The new antimalarial compound cipargamin showed antimalarial activity in healthy volunteers infected with blood-stage Plasmodium falciparum, although some subjects experienced serious liver function changes during treatment. Further evaluation of the compound's hepatic safety profile is needed despite the promising antimalarial activity observed.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Plant Sciences
Emmanuel O. Adeyoju, Clement O. Ajayi, Awodayo O. Adepiti, Anthony A. Elujoba
Summary: This study compared the antimalarial activity of methanol and water extracts of MAMA Powder against Plasmodium berghei-infected mice, finding that the water extract exhibited higher efficacy and can be optimized for chloroquine-resistant malaria, aiding in the production of various dosage forms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Theresa Hermann, Robin Wallner, Johanna Dolensky, Werner Seebacher, Eva-Maria Pferschy-Wenzig, Marcel Kaiser, Pascal Maser, Robert Weis
Summary: The compound MMV030666 in MMV's Malaria Box exhibits multi-stage activity against various strains of Plasmodium falciparum without resistance development. By modifying the structure, a series of compounds were prepared and the relationship between the structure and activity was revealed. Furthermore, the pharmacokinetic and physicochemical parameters were improved.
Article
Biochemistry & Molecular Biology
Luciano da Silva Pinto, Francisco Humberto Duebbern de Souza, Isabele Rodrigues Nascimento, Lucia Maria Xavier Lopes
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2015)
Article
Plant Sciences
Marcos D. P. Pereira, Matheus R. Ferreira, Gisele B. Messiano, Isabela Penna Ceravolo, Lucia M. X. Lopes, Antoniana U. Krettli
PHYTOCHEMISTRY LETTERS
(2015)
Article
Plant Sciences
Juliana R. Gubiani, Claudio R. Nogueira, Marcos D. P. Pereira, Maria C. M. Young, Paulo M. P. Ferreira, Manoel O. de Moraes, Claudia Pessoa, Vanderlan S. Bolzani, Angela R. Araujo
PHYTOCHEMISTRY LETTERS
(2016)
Article
Agricultural Engineering
Guilherme Pacheco, Claudio R. Nogueira, Andreia Bagliotti Meneguin, Eliane Trovatti, Maura C. C. Silva, Rachel T. A. Machado, Sidney J. L. Ribeiro, Edson C. Da Silva Filho, Hernane da S. Barud
INDUSTRIAL CROPS AND PRODUCTS
(2017)
Article
Plant Sciences
Juliana R. Gubiani, Maria L. Zeraik, Camila M. Oliveira, Valdecir F. Ximenes, Claudio R. Nogueira, Luiz M. Fonseca, Dulce H. S. Silva, Vanderlan S. Bolzani, Angela R. Araujo
JOURNAL OF NATURAL PRODUCTS
(2014)
Article
Plant Sciences
Erika M. de O. Ribeiro, Luciano S. Lima, Jorge M. David, Ademir E. do Vale, Lucia M. X. Lopes, Juceni P. David
PHYTOCHEMISTRY LETTERS
(2013)
Article
Chemistry, Multidisciplinary
Gislaine F. Martins, Marcos D. P. Pereira, Lucia M. X. Lopes, Tito da Silva, Paulo de T. Vieira e Rosa, Fernanda P. Barbosa, Gisele B. Messiano, Antoniana U. Krettli
Article
Chemistry, Medicinal
Sthephanie F. Cardoso, Lucia M. X. Lopes, Isabele R. Nascimento
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2014)
Article
Environmental Sciences
Marcia Ramos Jorge, Bruno do Amaral Crispim, Felipe Mendes Merey, Alexeia Barufatti, Isaias Cabrini, Fabiana Gomes da Silva Dantas, Kelly Mari Pires de Oliveira, Fabio Kummrow, Adilson Beatriz, Tiago Santos, Catarina Dias, Joao Ventura, Claudio Rodrigo Nogueira, Roberto da Silva Gomes, Eduardo Jose de Arruda
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Plant Sciences
Thais P. Banzato, Juliana R. Gubiani, Darlon I. Bernardi, Claudio R. Nogueira, Afif F. Monteiro, Fernanda F. Juliano, Severino M. de Alencar, Ronaldo A. Pilli, Carolina A. de Lima, Giovanna B. Longato, Antonio G. Ferreira, Mary Ann Foglio, Joao E. de Carvalho, Debora B. Vendramini-Costa, Roberto G. S. Berlinck
JOURNAL OF NATURAL PRODUCTS
(2020)
Article
Plant Sciences
Claudio Rodrigo Nogueira, Lidilhone Hamerski Carbonezi, Caroline Tieppo Flores de Oliveira, Walmir Silva Garcez, Fernanda Rodrigues Garcez
Summary: New bisabolane derivatives and related compounds were obtained from the leaves of Ocotea minarum, showing antifungal activity against Candida species and Cryptococcus neoformans in vitro.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Dayane C. Ribeiro, Helena M. Russo, Karina Fraige, Maria L. Zeraik, Claudio R. Nogueira, Patricia B. da Silva, Ana C. Codo, Giovana M. F. Calixto, Alexandra I. de Medeiros, Marlus Chorilli, Vanderlan S. Bolzani
Summary: The study identified four biflavonoids in the extracts of Platonia insignis fruit, with morelloflavone being the main compound responsible for its antioxidant and anti-glycant activities. The ethyl acetate extract from the shell also showed promising antioxidant and anti-inflammatory properties, making it a potential candidate for drug development from natural sources.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2021)
Article
Agronomy
Jose Darlan Alves da Silva, Claudio Rodrigo Nogueira, Maria do Carmo Viera, Silvia Cristina Heredia-Vieira, Alexeia Barufatti, Bruno do Amaral Crispim, Luiza Flivia Veiga Francisco, Lucilene Finoto Viana, Claudia Andrea Lima Cardoso
Meeting Abstract
Plant Sciences
C. R. Nogueira, L. M. Lopes
Meeting Abstract
Plant Sciences
C. R. Nogueira, L. M. Lopes
