Journal
MOLECULES
Volume 16, Issue 2, Pages 1297-1309Publisher
MDPI
DOI: 10.3390/molecules16021297
Keywords
triazolethioesters; oxadiazolethioesters; oxadiazoles; triazoles; in vitro antifungal activity
Funding
- University of Malaya [RG095/10AFR]
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A series of 5-substituted-4-amino-1,2,4-triazole-3-thioesters was synthesized by converting variously substituted organic acids successively into the corresponding esters, hydrazides, 5-substituted-1,3,4-oxadiazole-2-thiols, 5-substituted-1,2,4-triazole-2-thiols and 5-substituted-1,3,4-oxadiazole-2-thioesters. Finally the target compounds were obtained by refluxing 5-substituted-1,3,4-oxadiazole-2-thioesters in the presence of hydrazine hydrate and absolute alcohol. The structures of the synthesized compounds were established by physicochemical and spectroscopic methods. The synthesized compounds were evaluated for their in vitro antifungal activity. Some of the evaluated compounds possessed significant antifungal activity as compared to a terbinafine standard.
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