Article
Behavioral Sciences
Joanna Kowalczyk, Modestos Nakos-Bimpos, Alexia Polissidis, Christina Dalla, Nikolaos Kokras, Krystyna Skalicka-Wozniak, Barbara Budzynska
Summary: This study found that xanthotoxin can reduce depressive behaviors in male mice, while female mice have lower immobility levels compared to males, which may be related to higher levels of serotonin in the female prefrontal cortex. Additionally, xanthotoxin can lead to a dose-dependent increase in serotonin and noradrenaline levels in the female prefrontal cortex.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Shubao Yang, Chunlan Shan, Xin Ma, Yanjun Qin, Anqi Ju, Aoyi Duan, Weimin Luan, Yingnan Zhang
Summary: The study demonstrated that Acanthopanax senticosus polysaccharide may resist immunosuppression induced by cyclophosphamide and could be a potentially new immune adjuvant to enhance vaccination in normal and immunosuppressed chickens.
Article
Neurosciences
Ya-Nan Yin, Jian Hu, Yi-Li Wei, Ze-Lin Li, Zhou-Cai Luo, Rui-Qi Wang, Ke-Xin Yang, Shu-Ji Li, Xiao-Wen Li, Jian-Ming Yang, Tian-Ming Gao
Summary: All organisms experience stress, which can lead to mood disorders like depression. Research has shown that lactate in astrocytes plays a key role in modulating the passive coping response to behavioral challenges.
NEUROSCIENCE BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Xiaoya Wang, Xinyu Zhang, Jianqing Su, Xiuling Chu
Summary: In this study, the therapeutic effects of Acanthopanax senticosus total flavonoids (ASTFs) were investigated using a mouse intestinal inflammation model induced by lipopolysaccharide (LPS). The results showed that ASTF intervention improved intestinal morphology, reduced inflammatory markers and related gene expression levels, and regulated the structure of gut microbiota in mice. This suggests that ASTFs have potential therapeutic benefits in intestinal inflammation.
BIOSCIENCE REPORTS
(2022)
Article
Chemistry, Applied
Jiabo Cheng, Lequn Qiu, Naveed Ahmad, Jie Liu, Mengfei Tian, Chunying Li, Chunjian Zhao
Summary: ES contains compounds with significant anti-fatigue activity, but the active ingredients responsible for this effect are still unknown. This study aimed to establish the spectrum-effect relationship of ES's anti-fatigue activity and identify effective components. LC-MS/MS analysis of 15 ES samples revealed similarities ranging from 0.533 to 0.992, and the chemical structures of 22 common peaks were identified. The anti-fatigue activity of ES was evaluated through forced swimming tests in mice, and 9 components were found to be highly related to this activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Yan Liu, Peng Jiang, Mei-Ling Zhang, Juan Pan, Wei Guan, Xiao-Mao Li, Bing-You Yang, Hai-Xue Kuang
Summary: This study isolated new oleanane-type triterpenoid saponins and known saponins from the fruit of Acanthopanax senticosus, and determined their structures through extensive spectroscopic analysis and chemical methods. The neuroprotective effects of these compounds were evaluated in a neuroinflammation model.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jianqing Su, Xinyu Zhang, Qibin Kan, Xiuling Chu
Summary: The process of redox reaction in biological metabolism leads to the production of free radicals, which can cause oxidative stress and inflammation under certain conditions. Acanthopanax senticosus (A. senticosus) flavonoids have shown significant antioxidant properties, reducing oxidative damage and protecting cells or tissues both in vivo and in vitro through activation of the Nrf2 pathway.
Article
Instruments & Instrumentation
Xiangdong Zhang, Wanning Zhu
Summary: This paper investigates the effect of Acanthopanax senticosus on antifatigue activity after exercise through image effect observation. The experiment shows that Acanthopanax senticosus extract can improve antioxidant capacity and fight fatigue. This study provides a new method and solution for the research on antifatigue activity after exercise.
Article
Plant Sciences
Da-Ae Kwon, Yong Sang Kim, Seul-Ki Kim, Sin Hwa Baek, Hyun Kyu Kim, Hak Sung Lee
Summary: HemoHIM, an herbal formulation developed for immune regulation, was found to have significant antifatigue effects in both in vitro and in vivo models. The study demonstrated that HemoHIM improved antioxidant enzyme activity, endurance time, and glucose and glutathione levels while inhibiting lactate dehydrogenase and malondialdehyde production.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Najeeb Ur Rehman, Sulaiman Al-Shidhani, Nasiara Karim, Ajmal Khan, Imran Khan, Sobia Ahsan Halim, Sajid Khan Sadozai, Satya Kumar Avula, Rene Csuk, Ahmed Al-Harrasi
Summary: Through the study of derivatives of two active substances in the resin of Boswellia papyrifera, it is found that these derivatives have good anti-depressive properties and have great application potential. Further research indicates that these compounds produce GABAergic effects by binding to the GABA binding site of the GABA(A) receptor.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Soo-Jeung Park, Minhee Lee, Jeong-Moon Yun, Dakyung Kim, Dong Hwan Oh, Jinkyung Kim, Myeongkuk Shim, Hee-Jin Oh, Jeongmin Lee
Summary: In this study, it was found that the mixture of fermented deer velvet (FD) and fermented Eleutherococcus senticosus (FE) extract (FDE) regulated the immunity of animals that underwent induced immunosuppression. FDE intake led to increased cell counts for major histocompatibility complex (MHC) I, MHC II, CD4((+)) T cells, and CD8((+)) T cells, as well as enhanced cytokine production and T cell proliferation. FDE also inhibited Th2 cytokines and nitric oxide production, while promoting B cell proliferation and immunoglobulin levels. These results suggest that FDE has immunomodulatory capacity.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Neurosciences
Victor A. D. Holanda, Matheus C. Oliveira, Edilson D. da Silva Junior, Elaine C. Gavioli
Summary: The study indicates that tamsulosin may have antidepressant effects in patients with benign prostatic hyperplasia (BPH), but it may also contribute to increased susceptibility to depressive-like behaviors, which seems to be dependent on endogenous glucocorticoids.
BRAIN RESEARCH BULLETIN
(2022)
Article
Nutrition & Dietetics
Jingbin Li, Yang He, Jia Fu, Yimin Wang, Xing Fan, Tian Zhong, Hui Zhou
Summary: In this study, the protective effects of Acanthopanax senticosus extract (ASE) on MPTP-induced Parkinson's disease (PD) were investigated. ASE significantly improved motor coordination in mice with MPTP-induced PD. Proteomic analysis revealed that ASE modulated the expression of multiple proteins involved in Fc gamma receptor-mediated phagocytosis, PI3K/AKT signaling, and insulin receptor signaling pathways. Network analysis further showed that ASE regulated protein networks related to cellular assembly, lipid metabolism, and morphogenesis, suggesting its potential for treating PD.
FRONTIERS IN NUTRITION
(2023)
Article
Food Science & Technology
Zilin Li, Hongkang Zhu, Hanyi Hua, Chang Liu, Yuliang Cheng, Yahui Guo, Peng Du, He Qian
Summary: In this study, Brassica rapa L. extract (BE) was found to enhance exercise performance and alleviate fatigue in mice. The anti-fatigue effects of BE were attributed to its ability to regulate blood markers, antioxidant levels, and energy-related substances.
Article
Biochemistry & Molecular Biology
Mengtian Yu, Dongpo He, Yuhang Zhang, Dahao He, Xing Wang, Jinghui Zhou
Summary: The extraction method of lignin greatly influences its properties, with alkali method providing the best UV resistance for sunscreen formulations. Wood waste from Acanthopanax senticosus provides a new application for the treatment of herb residue waste.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
