Article
Polymer Science
Bruno Esteves, Pedro Aires, Umut Sen, Maria da Gloria Gomes, Raquel P. F. Guine, Idalina Domingos, Jose Ferreira, Helder Viana, Luisa P. Cruz-Lopes
Summary: The properties of particleboards made with young Paulownia trees from Portuguese plantations were studied. Single layer particleboards were produced with different processing parameters and board compositions to determine the best properties for use in dry environments. Particleboards meeting the requirements for dry environment could be produced with young Paulownia wood with a density of around 0.65 g/cm(3) and a thermal conductivity of 0.115 W/mK.
Article
Forestry
Hanna Park, Byeongho Kim, Kyoung-Chan Park, Yesun Kim, Taehee Kim, Min-Seok Kim, Sun-Eun Choi, Se-Yeong Park
Summary: This study aimed to collect baseline data on the biological resistance of sapwood and heartwood parts of Paulownia tomentosa wood in order to ensure its complete utilization. The researchers evaluated the decay and termite resistance of the wood, as well as the antimicrobial effect of its extracts. The results provide valuable insights for further research on porous wood materials and the utilization of active compounds from Paulownia wood.
Article
Medicine, Research & Experimental
Fabio Magurano, Matteo Micucci, Domenico Nuzzo, Melissa Baggieri, Pasquale Picone, Silvia Gioacchini, Raoul Fioravanti, Paola Bucci, Maedeh Kojouri, Michele Mari, Michele Retini, Roberta Budriesi, Laura Beatrice Mattioli, Ivan Corazza, Valentina Di Liberto, Luigi Todaro, Roberto Giuseppetti, Emilio D'Ugo, Antonella Marchi, Marisabel Mecca, Maurizio D'Auria
Summary: This study investigated the antiviral effect of Paulownia tomentosa extract against SARS-CoV-2 and its antioxidant properties, including respiratory smooth muscle relaxant effects. The results showed that the extract can inhibit viral replication by directly interacting with both the 3-chymotrypsin-like protease and spike protein. Additionally, it has a cyto-protective effect on lung epithelial cells damaged by tert-butyl hydroperoxide. These findings suggest the potential role of Paulownia tomentosa extract in COVID-19 treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Materials Science, Paper & Wood
Cosmin Spirchez, Veronica Japalela, Aurel Lunguleasa, Daniel Buduroi
Summary: The study showed that sawdust from Paulownia tomentosa and Paulownia elongata can be used to produce briquettes and pellets with good physical, mechanical, and energetic properties. The densities and calorific values of the products were within acceptable limits, making them suitable alternatives to other vegetable resources.
Article
Plant Sciences
Aigul Amirova, Symbat Dossymbetova, Yeldana Rysbayeva, Bakdaulet Usenbekov, Arman Tolegen, Alibek Ydyrys
Summary: The aim of this study was to investigate the effect of plant growth regulators on callus induction and in vitro morphogenesis of Paulownia tomentosa and develop an efficient plant regeneration protocol. It was found that the addition of TDZ and NAA stimulated somatic embryogenesis, while the combination of BAP and NAA was optimal for callus induction and multiple plant regeneration. The regenerative capacity of P. tomentosa varied depending on the type of explant, occurring through both callus formation and direct regeneration. Overall, this study successfully developed a reproducible protocol for embryogenic callus formation and multiple shoot induction in vitro, leading to an increased frequency of plant regeneration.
Article
Energy & Fuels
Paula Rodriguez-Seoane, Beatriz Diaz-Reinoso, Herminia Dominguez
Summary: The study explored the supercritical fluid extraction (SFE) of Paulownia elongata x fortunei leaves, finding that with the use of ethanol as a modifier, the extraction yield and antiradical properties can be enhanced under certain temperature and pressure conditions.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Plant Sciences
Lenka Molcanova, Jakub Treml, Veronika Brezani, Petr Marsik, Sebnem Kurhan, Zdenek Travnicek, Pavel Uhrin, Karel Smejkal
Summary: Paulownia tomentosa Steud., a traditional Chinese medicinal plant, is rich in phenolic compounds and has potential anti-inflammatory activities. This study isolated several flavonoids from the fruit of P. tomentosa and evaluated their cytotoxicity and anti-inflammatory effects. The results showed that these flavonoids reduced the activation of NF-KB/AP-1, indicating their potential as a source for new anti-inflammatory medications.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lenka Molcanova, Tereza Kauerova, Stefano Dall'Acqua, Petr Marsik, Peter Kollar, Karel Smejkal
Summary: Prenylated or geranylated flavonoids were isolated from Paulownia tomentosa Steud fruit, including seven new geranylated derivatives. These compounds showed concentration-dependent antiproliferative and cytotoxic effects on human monocytic leukaemia cell line THP-1. Diplacone was identified as the most potent agent, with 3'-O-methyl-5'-hydroxydiplacone showing potential as a lead compound for further testing.
BIOORGANIC CHEMISTRY
(2021)
Article
Forestry
Bruno Esteves, Luisa Cruz-Lopes, Helder Viana, Jose Ferreira, Idalina Domingos, Leonel J. R. Nunes
Summary: This study aims to determine the best age for cutting young Paulownia trees in Portuguese plantations. According to the results, the 5-year-old samples showed the best characteristics for pellet production.
Article
Biochemistry & Molecular Biology
Gabriela Orbenes, Paula Rodriguez-Seoane, Maria Dolores Torres, Rolando Chamy, Maria Elvira Zuniga, Herminia Dominguez
Summary: The study assessed the integral valorization of artichoke bracts generated during industrial canning, by extracting bioactive compounds using pressurized hot water under subcritical conditions. It compared the efficiency of conventional and microwave heating on the extraction of phenolics and saccharidic fraction, with microwave-assisted process proving to be more efficient in terms of yields and time needed.
Article
Biochemistry & Molecular Biology
Lucia Morote, Angela Rubio-Moraga, Alberto Jose Lopez-Jimenez, Javier Argandona, Enrique Niza, Oussama Ahrazem, Lourdes Gomez-Gomez
Summary: Paulownia tomentosa, a fast-growing tree, is economically important due to its flowers and fruits which contain biologically active secondary metabolites. The flowers have a strong aroma and serve as excellent nectar plants for pollinators. The color changes in the flowers, caused by the presence of carotenoids, act as reliable signals for pollinators and contribute to reproductive success. The gene expression analysis revealed that a gene called CCD4-4 is correlated with the levels of beta-carotene in the nectar guides, indicating a developmental stage-specific regulation of carotenoid cleavage. Analysis of volatile production and color changes suggests that these traits are important for plant-pollinator interactions. Data availability: Data will be made available on request.
Article
Forestry
Bruno Esteves, Helena Ferreira, Helder Viana, Jose Ferreira, Idalina Domingos, Luisa Cruz-Lopes, Dennis Jones, Lina Nunes
Summary: The study aimed to investigate the potential use of heat-treated young Paulownia trees grown in Portugal to improve wood properties, showing an increase in extractive content, lignin, and alpha-cellulose, a decrease in hemicelluloses, improved dimensional stability but decreased mechanical properties. The resistance against termites was better for untreated wood possibly due to the thermal degradation of some toxic extractives.
Article
Agriculture, Multidisciplinary
Yousef Sohrabi, Firouzeh Sharifi Kalyani, Moslem Heydari, Majed Yazdani, Khalid M. Omer, Ali Reza Yousefi
Summary: This study synthesized nano-fertilizer from Paulownia leaves and examined its effectiveness in alleviating drought stress in Basil plants. The results showed that the nano-fertilizer improved plant growth and photosynthesis, reducing the negative effects of drought stress.
CHEMICAL AND BIOLOGICAL TECHNOLOGIES IN AGRICULTURE
(2022)
Article
Polymer Science
Kyoung-Chan Park, Byeongho Kim, Hanna Park, Yesun Kim, Se-Yeong Park
Summary: Paulownia tomentosa was selected as an experimental wood species for the efficient production of translucent wood through a two-step process of delignification and polymer impregnation. The properties of the resulting translucent wood varied according to the wood section, with higher transmittance and haze observed in the cross-section compared to the tangential section. The bending strength of the wood was improved through epoxy impregnation.
Article
Biology
Marwa E. Mohamad, A. A. Awad, Ali Majrashi, O. A. Abd Esadek, Mohamed T. El-Saadony, Ahmed M. Saad, Ahmed S. Gendy
Summary: This study developed an efficient protocol for in vitro mass production of Paulownia seedlings using seed explant, and identified the optimal treatments for multiplication and adaptation stages.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Antonietta Cerulli, Assunta Napolitano, Jan Hosek, Milena Masullo, Cosimo Pizza, Sonia Piacente
Summary: The Italian Marrone di Roccadaspide (Castanea sativa), a PGI product, has been studied for its chemical composition and antioxidant activity in burs, leaves, and chestnuts, revealing a correlation between antioxidant activity and high tannins and flavonoids content, as well as potential anti-inflammatory effects of polar lipids in leaves.
Article
Biochemistry & Molecular Biology
Jiri Kos, Violetta Kozik, Dominika Pindjakova, Timotej Jankech, Adam Smolinski, Sarka Stepankova, Jan Hosek, Michal Oravec, Josef Jampilek, Andrzej Bak
Summary: A library of novel 4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid amides was designed and synthesized to provide potential AChE/BChE inhibitors, with specific in vitro inhibitory profiles and selectivity indices. The most potent AChE inhibitor was benzyl(3-hydroxy-4-{[2-(trifluoromethoxy)phenyl]carbamoyl}phenyl)carbamate, while the most potent BChE inhibitor was benzyl{3-hydroxy-4-[(2-methoxyphenyl)carbamoyl]phenyl}-carbamate with high selectivity for BChE. Molecular docking studies revealed hydrophobic and hydrogen bond interactions with specific amino acid residues, and molecular dynamic simulations were used to assess the stability of liganded enzymatic systems. Overall, the study aimed to explain differences in selectivity indices for the most potent molecules containing unsubstituted and fluorinated methoxy groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Correction
Multidisciplinary Sciences
Iva Synkova, Marketa Bebarova, Irena Andrsova, Larisa Chmelikova, Olga Svecova, Jan Hosek, Michal Pasek, Pavel Vit, Iveta Valaskova, Renata Gaillyova, Rostislav Navratil, Tomas Novotny
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jan Vanco, Zdenek Travnicek, Jan Hosek, Tomas Malina, Zdenek Dvorak
Summary: A series of new heteroleptic copper(II) complexes were prepared and showed effective antiproliferative activity against various human cancer cell lines, while exhibiting low toxicity on healthy human cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jan Vanco, Zdenek Travnicek, Jan Hosek, Zdenek Dvorak
Summary: Heteroleptic copper(II) complexes containing prenylated flavonoid osajin were synthesized and characterized, showing high antiproliferative activity against cancer cells with low toxicity towards human hepatocytes. These complexes also demonstrated strong in vitro nuclease effect and anti-inflammatory properties.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Tomas Strharsky, Dominika Pindjakova, Jiri Kos, Lucia Vrablova, Hana Michnova, Jan Hosek, Nicol Strakova, Veronika Lelakova, Lenka Leva, Lenka Kavanova, Michal Oravec, Alois Cizek, Josef Jampilek
Summary: A series of compounds were designed and characterized, showing good antibacterial and anticancer activities with low cytotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Chemistry, Multidisciplinary
Gregorio Peron, Jan Hosek
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Jan Stastny, Petr Marsik, Jan Tauchen, Matej Bozik, Anna Mascellani, Jaroslav Havlik, Premysl Landa, Ivan Jablonsky, Jakub Treml, Petra Herczogova, Roman Bleha, Andriy Synytsya, Pavel Kloucek
Summary: Edible medicinal mushrooms within the higher fungi group have a long history of being used for food and folk medicine. The Pleurotus genus, represented by Pleurotus ostreatus, has been widely cultivated and studied. In this study, lesser-known Pleurotus species were examined for their antioxidant and anti-inflammatory activities. Significant differences were found among the extracts, with P. flabellatus showing strong radical scavenging activity and P. ostreatus Florida demonstrating potent NF-kappa B inhibition. These findings suggest the therapeutic potential of these mushrooms for further investigation and clinical trials.
Article
Biochemistry & Molecular Biology
Dominika Pindjakova, Eliska Pilarova, Karel Pauk, Hana Michnova, Jan Hosek, Pratibha Magar, Alois Cizek, Ales Imramovsky, Josef Jampilek
Summary: Two compounds (3e and 3f) derived from benzylated intermediates and target compounds showed broad-spectrum activity against reference and clinical isolates of bacteria and mycobacteria. They exhibited high activity against Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis, Mycobacterium tuberculosis, and M. smegmatis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Lenka Molcanova, Jakub Treml, Veronika Brezani, Petr Marsik, Sebnem Kurhan, Zdenek Travnicek, Pavel Uhrin, Karel Smejkal
Summary: Paulownia tomentosa Steud., a traditional Chinese medicinal plant, is rich in phenolic compounds and has potential anti-inflammatory activities. This study isolated several flavonoids from the fruit of P. tomentosa and evaluated their cytotoxicity and anti-inflammatory effects. The results showed that these flavonoids reduced the activation of NF-KB/AP-1, indicating their potential as a source for new anti-inflammatory medications.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Physical
Martin Pisarcik, Milos Lukac, Josef Jampilek, L'udmila Paskova, Frantisek Bilka, Andrea Bilkova, Ferdinand Devinsky, Jakub Val'ko, Renata Horakova, Jan Hosek, Matej Brezina, Tomas Opravil
Summary: Gold nanoparticles were prepared and stabilized using Gemini surfactants with varying lengths of poly-methylene spacer. The size of the nanoparticles was found to be influenced by the spacer length of the stabilizing surfactants. Short spacer lengths led to aggregation and larger particle clusters, while longer spacer lengths resulted in smaller nanoparticles. The shape of the gold nanoparticles was observed to be spherical and polyhedral. The nanoparticles exhibited positive zeta potential values and their biological activity was found to be dependent on the spacer length of the stabilizing molecules.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemistry & Molecular Biology
Tomas Strharsky, Dominika Pindjakova, Jiri Kos, Lucia Vrablova, Pavel Smak, Hana Michnova, Tomas Gonec, Jan Hosek, Michal Oravec, Izabela Jendrzejewska, Alois Cizek, Josef Jampilek
Summary: A series of 32 anilides with antimicrobial activity were prepared by microwave-assisted synthesis, showing potential for antibacterial applications against Staphylococcus aureus and Enterococcus faecalis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Akimasa Iijima, Olga Svecova, Jan Hosek, Roman Kula, Marketa Bebarova
Summary: This study found that sildenafil, the orally administered drug for treating erectile dysfunction, could inhibit both the inward and outward current components of the ventricular IK1 channels in the human body, which may contribute to arrhythmias. Additionally, low concentrations of the environmental contaminant Ba2+ can enhance the inhibitory effect of sildenafil on these channels, leading to increased risk of cardiac repolarization delay.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Materials Science, Paper & Wood
M. Sedlar, K. Kacvinska, Z. Fohlerova, D. Izsak, M. Chalupova, P. Suchy, M. Dohnalova, T. Sopuch, L. Vojtova
Summary: This study evaluated the hemostatic effect of freeze-dried wound dressings based on equine collagen, porcine collagen, fibrous carboxymethyl cellulose (CMC) and their mixtures. The addition of fibrous CMC into collagen-based hemostatic wound dressings showed a strong synergistic effect, improving absorption capacity and supporting clotting time. In vivo studies demonstrated that the mixture of equine collagen and CMC had better hemostatic efficacy compared to a commonly used hemostatic sealing patch.
Article
Biochemistry & Molecular Biology
Zdenek Travnicek, Jan Vanco, Jan Belza, Jan Hosek, Zdenek Dvorak, Rene Lenobel, Igor Popa, Karel Smejkal, Pavel Uhrin
Summary: Motivated by the success of Auranofin, a gold(I) metallotherapeutic, in treating inflammation and cancer, the researchers prepared and characterized a [Au(kin)(PPh3)] complex (1) with kinetin. In vitro studies showed that complex (1) had significant cytotoxicity against human cancer cell lines, outperforming Cisplatin and comparable to Auranofin. Furthermore, it was found to positively influence PPAR gamma, reducing inflammation. The cellular effects of complex (1) were also investigated, revealing its impact on cell cycle, apoptosis, ROS production, caspase activation, mitochondrial membrane potential, and proteomic analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
