Journal
MOLECULES
Volume 14, Issue 6, Pages 2246-2253Publisher
MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
DOI: 10.3390/molecules14062246
Keywords
Allium macrostemon Bunge; steroidal saponins; cytotoxic activity
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Two new steroidal saponins (1 and 2) were isolated from the dried bulbs of Allium macrostemon Bunge. Their structures were elucidated by the spectral data as 26-O-beta-D-glucopyranosyl-5 alpha-furost-25 (27)-ene-3 beta, 12 beta, 22, 26-tetraol-3-O-beta-D-glucopyranosyl (1 -> 2) [beta-D-glucopyranosyl (1 -> 3)]-beta-D-glucopyranosyl (1 -> 4)-beta-D-galactopyranoside (1) and 26-O-beta-D-glucopyranosyl-5 beta-furost-20 (22)-25 (27)-dien-3 beta, 12 beta, 26-triol-3-O-beta-D-glucopyranosyl (1 -> 2)-beta-D-galactopyranoside (2), respectively. Their cytotoxic activities on several cancer cell lines (MCF-7, NCI-H460, SF-268 and HepG2) were tested. 1 showed special cytotoxity on SF- 268, while 2 showed cytotoxity on NCI-H460 and SF-268 cell lines, respectively.
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