Article
Medicine, Research & Experimental
Jihye Kim, Epameinondas Gousopoulos, Teresa M. Faleschini, Matthias Hamburger, Olivier Potterat, Michael Detmar
Summary: The lymphatic vascular system plays a crucial role in maintaining tissue fluid homeostasis and immune surveillance. Promoting lymphatic function can be a new approach to treat various diseases. Through screening of plant extracts, pheophorbide a was identified as a compound that can induce lymphangiogenesis. Pheophorbide a may serve as a novel natural therapeutic agent to treat human lymphatic vascular insufficiencies.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Plant Sciences
Moonmoon Sinha, Urmita Chakraborty, Anirban Kool, Mousumi Chakravarti, Souvik Das, Sandip Ghosh, Lovnish Thakur, Anil Khuranna, Debadatta Nayak, Biswarup Basu, Subhabrata Kar, Raja Ray, Satadal Das
Summary: The study indicates that Eupatorium perfoliatum extract has significant antiviral activity against DENV infection, with quercetin potentially playing a key role in this activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Marcela H. Retamozo, Christian C. Silva, Cinthia I. Tamayose, Juliana C. S. Carvalho, Paulete Romoff, Oriana A. Favero, Marcelo J. P. Ferreira
Summary: This study investigated the phytochemical composition of Baccharis sphenophylla and found the presence of bioactive compounds such as diterpenoids, flavonoids, caffeic acid, and chlorogenic acid derivatives. The extract and isolated compounds showed high antioxidant activity in two assays, indicating that B. sphenophylla is an important source of phenolic compounds with antiradical properties.
Article
Pharmacology & Pharmacy
Guanjie Liu, Ling Chang, Yihan Qian, Jiacheng Lin, Zhi Shang, Min Xu, Fang Wang, Xuehua Sun, Yun Jiang, Yueqiu Gao, Xiaoni Kong
Summary: The study found that Polygonum perfoliatum L. (PPL) can protect against hepatic steatosis, lipid peroxidation, and glucose-lipid metabolism dysfunction in NAFLD mice. This is achieved through altering the PPARs/CPT1A/CPT2-mediated hepatic fatty acid beta-oxidation process. The active components of PPL with anti-NAFLD activity were identified using UPLC/QE-HFX.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Chemistry, Analytical
Daniil N. Olennikov
Summary: This review provides information on the chemodiversity of Serratula and Klasea species and their potential as sources of bioactive metabolites.
Article
Agronomy
Vhuthu Ndou, Petrus Jacobus Pieterse, Dirk Jacobus Brand, Alvera Vorster, Amandrie Louw, Ethel Phiri
Summary: A glyphosate-resistant plantago population in South Africa was found to be 43-fold resistant to glyphosate due to a point mutation in the EPSPS gene and lower shikimate accumulation. This rapid evolution of resistance threatens global food production and requires new weed management strategies.
Article
Plant Sciences
Jona Suric, Jana Sic Zlabur, Anamarija Peter, Ivan Brandic, Sandra Voca, Mia Dujmovic, Josip Leto, Neven Voca
Summary: The world is facing challenges of expensive non-renewable energy and decreasing agricultural land for food production. Energy crops like Sida hermaphrodita L. and Silphium perfoliatum L. offer a potential solution. Analyzing the energetic, nutritional, and functional potential of these plants at different growth stages revealed their high value in terms of energy and bioactive compounds.
Article
Chemistry, Applied
Klaudia Michalska, Janusz Malarz, Anna Stojakowska
Summary: This report presents the first study on the natural products of the previously unstudied Lactuca plumieri, identifying five sesquiterpene lactones and one coumarin. Additionally, analysis showed the presence of caffeic acid derivatives, coumarins, and flavonoids in the aerial parts of the plant.
NATURAL PRODUCT RESEARCH
(2022)
Article
Environmental Sciences
Shanying Zhang, Fengman Yin, Jiahao Li, Saihao Ren, Xiaoyu Liang, Yu Zhang, Lifeng Wang, Meng Wang, Chenghui Zhang
Summary: This study explores the mechanisms of the effects of acetamiprid (ACE), cyromazine (CYR), and their mixture (MIX) on cowpea using metabolomic and transcriptomic methods. The results show that these pesticides do not significantly affect the plant's biomass or growth status but reduce the contents of starch, soluble protein, and total flavonoids. ACE affects amino acid metabolism, while CYR and MIX affect sugar metabolism and flavonoid synthesis pathways. MIX causes the most significant decrease in the metabolite content of cowpea.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Chemistry, Medicinal
Laura C. Laurella, Orlando G. Elso, Rachel Napoles Rodriguez, Juan M. Viecenz, Maria Rosario Alonso, Esteban J. Bontempi, Emilio Malchiodi, Cesar A. N. Catalan, Silvia I. Cazorla, Valeria P. Sulsen
Summary: This study isolated and identified bioactive compounds, including miscandenin and onopordin, from the dichloromethane extract of Mikania periplocifolia. These compounds showed antiprotozoal activity against Trypanosoma cruzi, T. brucei, and Leishmania braziliensis. Miscandenin in particular exhibited strong antiprotozoal activity. The pharmacokinetic and physicochemical properties of miscandenin were also assessed, demonstrating its potential as a candidate for further preclinical studies.
Article
Pharmacology & Pharmacy
Muna Ali Abdalla, Fengjie Li, Arlette Wenzel-Storjohann, Saad Sulieman, Deniz Tasdemir, Karl H. Muehling
Summary: This study assessed the effects of sulfur (S) nutrition on hydroponically grown lettuce cultivars, finding significant differences in growth, quality, secondary metabolites, and antibacterial activity among different sulfur treatments and lettuce cultivars. The judicious application of S was shown to play a critical role in plant growth, acclimation, and nutritional quality, with potential applications as a promising antimicrobial prototype for medical use.
Article
Chemistry, Medicinal
Ziang Chen, Chang-Qiang Ke, Shuaizhen Zhou, Lu Feng, Chunping Tang, Yang Ye
Summary: Ten undescribed cadinane-type sesquiterpenes were isolated from the whole plant of Eupatorium chinense. Their planar structures were elucidated mainly through analysis of spectroscopic data and DFT NMR calculations, with the absolute configurations determined by various experimental methods. A possible biosynthetic pathway for these new sesquiterpenes was proposed.
Article
Plant Sciences
Pinglong Fan, Shuchun Xie, Zhiqian Zhang, Quan Yuan, Jiajiang He, Jie Zhang, Xinyue Liu, Xiaoyi Liu, Lieqiang Xu
Summary: Polygonum perfoliatum L. ethanol extract (PPE) exhibits potential as a safe therapeutic agent for atopic dermatitis by efficiently mitigating DNCB-induced atopic symptoms and diminishing inflammation, and does not carry the risk of over-immunosuppression or treatment-associated adverse effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Deepak Timalsina, Hari Prasad Devkota
Summary: This review summarizes the traditional uses, phytoconstituents, and biological activities of Eclipta prostrata, a medicinal plant widely used in tropical and subtropical regions. The active phytochemicals of E. prostrata include coumestan derivatives, phenolic acid derivatives, flavonoids, triterpenoid and steroid saponins, and substituted thiophenes. Studies on the detailed mechanism and clinical effects of these phytoconstituents are necessary for future research.
Article
Plant Sciences
Reda E. Abdelhameed, Arafat Abdel Hamed Abdel Latef, Rania S. Shehata
Summary: Foliar application of salicylic acid improves salt tolerance of fenugreek plants by increasing chlorophyll content index and reducing malondialdehyde content, while promoting accumulation of proline, total phenolics, and flavonoids. Additionally, it enhances total free amino acids and shikimic acid, and activates antioxidant enzymes such as ascorbate peroxidase, peroxidase, polyphenol oxidase, and catalase.
