Journal
MOLECULES
Volume 14, Issue 1, Pages 122-132Publisher
MDPI
DOI: 10.3390/molecules14010122
Keywords
Neem oil; MEX; Cytoxicity; Lipo-peroxidation; Cell Membrane
Funding
- Italian Ministry of Education (MIUR)
- Regione Lazio (FILAS, Finanziaria Laziale Sviluppo)
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Neem oil is obtained from the seeds of the tree Azadirachta indica. Its chemical composition is very complex, being rich in terpenoids and limonoids, as well as volatile sulphur modified compounds. This work focused on the evaluation of a component of the whole Neem oil obtained by methanolic extraction and defined as MEX. Cytotoxicity was assessed on two different cell populations: a stabilized murine fibroblast line (3T6) and a tumor cell line (HeLa). The data presented here suggest a differential sensitivity of these two populations, the tumor line exhibiting a significantly higher sensitivity to MEX. The data strongly suggest that its toxic target is the cell membrane. In addition the results presented here imply that MEX may contain one or more agents that could find a potential use in anti-proliferative therapy.
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