Article
Pharmacology & Pharmacy
Monica Cerqueira, Efres Belmonte-Reche, Juan Gallo, Fatima Baltazar, Manuel Banobre-Lopez
Summary: Cancer is a leading cause of death worldwide, with a projected increase in global cancer incidence in the next two decades. Nanomedicine formulations have the potential to improve the effectiveness of conventional cancer therapies. However, the targeting efficiency of advanced nanomedicines in oncology is currently one of the major limitations, highlighting the need for more efficient nanoformulation designs.
Article
Immunology
Priyanka Jain, Vikas Pandey, Vandana Soni
Summary: This study aimed to develop tween 80-coated solid lipid nanoparticles (SLNs) loaded with folic acid-doxorubicin (FAD) conjugate for targeted drug delivery to brain cancer cells. The results confirmed the high antitumour activity of the SLNs against brain cancer cells.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Joana Torres, Jose Miguel Pereira, Rita Marques-Oliveira, Ines Costa, Eva Gil-Martins, Renata Silva, Fernando Remiao, Andreia Filipa Peixoto, Jose Manuel Sousa Lobo, Ana Catarina Silva
Summary: This study investigated the use of lipid nanoparticles, including solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), for intranasal delivery of astaxanthin. The formulations loaded with astaxanthin from different sources (algae Haematococcus pluvialis extract (AE) and fungi Blakeslea trispora extract (PA)) were evaluated for biocompatibility with nasal (RPMI 2650) and neuronal (SH-SY5Y) cells, antioxidant activity, and cellular uptake. The PA-loaded NLC formulation showed promising neuroprotective effects, suggesting its potential for improving the treatment of neurodegenerative diseases.
Article
Pharmacology & Pharmacy
Sonia Trombino, Rocco Malivindi, Giuseppe Barbarossa, Roberta Sole, Federica Curcio, Roberta Cassano
Summary: Classical melanoma therapy often has side effects, affecting the efficacy and patient compliance. Drug delivery systems, such as solid lipid nanoparticles (SLNs), can improve drug stability, release kinetics, and enhance therapy safety and efficacy. In this study, SLNs were prepared using hydroquinone esterified with stearic acid and characterized using FT-IR and H-1-NMR. The efficacy of SLNs on COLO-38 human melanoma cells were evaluated, and their potential effects on apoptotic mechanisms were analyzed. Safety tests, cytotoxicity evaluation, and antioxidant and anti-inflammatory activities were also conducted.
Article
Pharmacology & Pharmacy
Mushfiq Akanda, Giullia Getti, Uttom Nandi, Md Sadeque Mithu, Dennis Douroumis
Summary: The study developed transferrin bioconjugated solid lipid nanoparticles for targeted delivery of curcumin to prostate cancer cells, showing significant anti-proliferative activity and enhanced apoptotic effects, both in vitro and in vivo.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Wei Xu, Zhaoyou Deng, Yifei Xiang, Dujuan Zhu, Dandan Yi, Yihao Mo, Yu Liu, Lanqian Qin, Ling Huang, Bingjie Wan, Liqin Wu, Xin Feng, Jiakang He
Summary: In this study, a tolfenamic acid solid lipid nanoparticle (TA-SLN) suspension was prepared to improve the sustained release and bioavailability of nonsteroidal anti-inflammatory drugs. The TA-SLN suspension showed improved sustained drug release in vitro and increased pharmacokinetic parameters in pigs compared with TA injection, indicating its potential as a promising new formulation.
Review
Engineering, Biomedical
Chinmay M. Jogdeo, Sudipta Panja, Shrey Kanvinde, Ekta Kapoor, Kasturi Siddhanta, David Oupicky
Summary: Combination therapy is effective in cancer and inflammatory diseases, and lipid-based codelivery systems have attracted attention due to their low toxicity, biocompatibility, and ease of formulation scale-up.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Multidisciplinary Sciences
Hamdi Nsairat, Dima Khater, Fadwa Odeh, Fedaa Al-Adaileh, Suma Al-Taher, Areej M. Jaber, Walhan Alshaer, Abeer Al Bawab, Mohammad S. Mubarak
Summary: Advancements in material science and bionanotechnology have driven the use of nanoparticles in healthcare to improve diagnosis, monitoring, and therapy. Lipid nanostructures play a crucial role in combating brain tumors, with research focusing on solid lipid nanoparticles and nanostructured lipid carriers for overcoming the blood brain barrier and increasing effectiveness.
Article
Nanoscience & Nanotechnology
Sony Chandi Shrestha, Kebreab Ghebremeskel, Kenneth White, Caterina Minelli, Ihab Tewfik, Panna Thapa, Sundus Tewfik
Summary: In this study, solid lipid nanoparticles containing phytostanol esters were successfully formulated and characterized. The optimized formulation showed high drug entrapment efficiency, good drug loading, and excellent nanoparticle yield. The nanoparticles exhibited spherical shape, negative surface charge, and demonstrated biological safety and uptake in hepatic and intestinal cell lines. These findings suggest that the formulation has the potential to serve as an innovative drug delivery system for phytostanols, contributing to better management of cardiovascular diseases.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Pharmacology & Pharmacy
Julia German-Cortes, Mireia Vilar-Hernandez, Diana Rafael, Ibane Abasolo, Fernanda Andrade
Summary: Nanotechnology has made significant contributions to cancer treatment by improving the effectiveness and specificity of chemotherapy through the use of nanoparticles, particularly solid lipid nanoparticles (SLNs). SLNs offer higher stability, active targeting, sustained and controlled release, and multifunctional therapy, making them an ideal drug delivery system.
Article
Chemistry, Applied
Wangxin Liu, Xianliang Luo, Tao Liu, Fengqin Feng
Summary: S-BL and S-LBL obtained through structural adjustment showed ideal sustained-release effects on glycerol monolaurate in vitro and in vivo, and possibly had positive impacts on gut microbes.
Article
Nanoscience & Nanotechnology
Huiyang Wang, Siqi Wang, Xisong Zhu, Wenxiu Ding, Tianlun Shen, Hongjie Fan, Yanhua Zhang, Lijun Peng, Hong Yuan, Xiangrui Liu, Jun Ling, Jihong Sun
Summary: In this study, an iron-based solid lipid nanoparticle (SLN) was developed, which can be absorbed by the intestinal wall and enhance contrast in MRI. Experimental results using mouse models showed that the SLN has better diagnostic value for acute ulcerative colitis and colon adenocarcinoma. Confocal fluorescence microscopy confirmed that the SLN mainly distributes in the intestinal mucosa and tumor capsule.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ana Flavia Piquera Santos, Lara Cristina Cunha Cervantes, Layla Panahipour, Francisley Avila Souza, Reinhard Gruber
Summary: Short-chain fatty acids (SCFAs) are potent immune modulators that may play a role in periodontal health and disease. This study found that butyrate effectively reduced the inflammatory response in macrophages, gingival fibroblasts, and oral epithelial cells. Propionate and acetate also had some anti-inflammatory effects, but not to a significant level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Azadeh Emami, Hossein Ghafouri, Reyhaneh Sariri
Summary: This study developed and optimized a PD-loaded SLN formulation and evaluated its efficacy in breast cancer cell lines. Apoptosis was confirmed as the mechanism of cell death, and the PD-loaded SLN showed significant increase in apoptosis. In vivo studies on mice also supported this effect. PD-loaded SLN may be a promising breast cancer treatment without recognizable side effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Mushfiq Akanda, Sadeque Hossain Mithu, Dennis Douroumis
Summary: Solid lipid nanoparticles (SLN) are at the forefront of nanotechnology, with potential applications in drug delivery and research. They offer controlled and site-specific drug delivery, making them a popular choice over other colloidal carriers. This review discusses the production techniques, drug incorporation, and release mechanisms of SLN. The route of administration and in vivo fate of SLNs are also explored, along with their potential in anti-cancer drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Baptiste Lacoste, Debora Angeloni, Sergio Dominguez-Lopez, Sara Calderoni, Alessandro Mauro, Franco Fraschini, Laurent Descarries, Gabriella Gobbi
JOURNAL OF PINEAL RESEARCH
(2015)
Article
Psychiatry
Federica Scarpina, Nicola Cau, Veronica Cimolin, Manuela Galli, Gianluca Castelnuovo, Lorenzo Priano, Lucia Pianta, Stefania Corti, Alessandro Mauro, Paolo Capodaglio
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2017)
Article
Nutrition & Dietetics
Stefania Mai, Gillian E. Walker, Roberta Vietti, Stefania Cattaldo, Chiara Mele, Lorenzo Priano, Alessandro Mauro, Gianni Bona, Gianluca Aimaretti, Massimo Scacchi, Paolo Marzullo
Article
Chemistry, Analytical
Claudia Ferraris, Roberto Nerino, Antonio Chimienti, Giuseppe Pettiti, Nicola Cau, Veronica Cimolin, Corrado Azzaro, Giovanni Albani, Lorenzo Priano, Alessandro Mauro
Article
Integrative & Complementary Medicine
Giovanni Albani, Giuseppe Veneziano, Clara Lunardon, Calogero Vinci, Alessandra Daniele, Federico Cossa, Alessandro Mauro
COMPLEMENTARY THERAPIES IN MEDICINE
(2019)
Review
Chemistry, Analytical
Serena Cerfoglio, Claudia Ferraris, Luca Vismara, Gianluca Amprimo, Lorenzo Priano, Giuseppe Pettiti, Manuela Galli, Alessandro Mauro, Veronica Cimolin
Summary: This review provides an overview of the current state of the utilization of Microsoft Kinect camera as a tool for assessing gait in post-stroke individuals. The studies reviewed have explored the potential, accuracy, and effectiveness of this 3D optical sensor in evaluating gait parameters in various pathologies. However, due to the heterogeneity in participants, measures, methodologies, and study purposes, it is challenging to compare the findings and determine the strengths and weaknesses of this technology in the post-stroke population.
Article
Multidisciplinary Sciences
Flavia Marrone, Massimiliano Pau, Luca Vismara, Micaela Porta, Matteo Bigoni, Bruno Leban, Serena Cerfoglio, Manuela Galli, Alessandro Mauro, Veronica Cimolin
Summary: The aim of this study was to assess inter-limb symmetry during gait in post-stroke patients using the synchronized cyclograms technique. The results showed that post-stroke patients had abnormal gait parameters and higher inter-limb symmetry compared to the control group. Achieving symmetry in gait is crucial for the rehabilitation of hemiplegic people.
Article
Neurosciences
Luca Vismara, Veronica Cimolin, Francesca Buffone, Matteo Bigoni, Daniela Clerici, Serena Cerfoglio, Manuela Galli, Alessandro Mauro
Summary: Brain asymmetry affects motor performance, leading to different gait patterns in hemiparetic patients depending on the side of the lesion. This retrospective cohort study compared the differences between right and left hemiplegia, finding that the injured side can influence the clinical characteristics of gait. The study suggests that personalized rehabilitation strategies should consider the side of the lesion and brain asymmetry.
Article
Chemistry, Analytical
Claudia Ferraris, Gianluca Amprimo, Giulia Masi, Luca Vismara, Riccardo Cremascoli, Serena Sinagra, Giuseppe Pettiti, Alessandro Mauro, Lorenzo Priano
Summary: This paper presents a gait analysis system based on Microsoft Azure Kinect DK sensor and its body-tracking algorithm, which allows objective assessment of arm swing features during walking. The system can help prevent adverse consequences, provide appropriate treatments and rehabilitation protocols.
Article
Chemistry, Analytical
Gianluca Amprimo, Giulia Masi, Lorenzo Priano, Corrado Azzaro, Federica Galli, Giuseppe Pettiti, Alessandro Mauro, Claudia Ferraris
Summary: Motor impairments are significant symptoms of Parkinson's disease, negatively impacting the quality of life. Physiotherapy and rehabilitation programs have been shown to improve motor control and coordination in Parkinsonian patients. However, traditional rehabilitation pathways may become unsustainable due to the increasing number of patients. Therefore, new strategies are needed, utilizing technologies for remote assessment, monitoring, and rehabilitation.
Article
Nutrition & Dietetics
Federica Scarpina, Silvia Turroni, Sara Mambrini, Monica Barone, Stefania Cattaldo, Stefania Mai, Elisa Prina, Ilaria Bastoni, Simone Cappelli, Gianluca Castelnuovo, Patrizia Brigidi, Massimo Scacchi, Alessandro Mauro
Summary: This exploratory pilot study provides novel experimental evidence of a relationship between gut microbiota composition and diversity, and fear-processing in obesity, suggesting potential microbiome-based strategies for the treatment of psychological difficulties.
Article
Chemistry, Analytical
Claudia Ferraris, Irene Ronga, Roberto Pratola, Guido Coppo, Tea Bosso, Sara Falco, Gianluca Amprimo, Giuseppe Pettiti, Simone Lo Priore, Lorenzo Priano, Alessandro Mauro, Debora Desideri
Summary: With the progressive aging of the population and the increase in neurological diseases, telemedicine and e-health solutions are becoming more important. The REHOME project aims to provide remote monitoring and rehabilitation for cognitive, motor, and sleep disorders associated with neurological diseases. Preliminary results of usability and user experience questionnaires are presented.
Article
Neurosciences
Giulia Vaioli, Sofia Tagini, Federica Scarpina, Riccardo Cremascoli, Lorenzo Priano, Mauro Cornacchia, Paolo Fanari, Alessandro Mauro
Summary: The Obstructive Sleep Apnea Syndrome (OSAS) has a significant impact on cognitive functioning. A short-term use of CPAP (less than 15 days) has been found to improve certain cognitive functions in OSAS patients, particularly verbal memory and learning. The study emphasizes the importance of early use of CPAP for rapid improvement in cognitive functioning.
Review
Biochemistry & Molecular Biology
Riccardo Soffietti, Alessia Pellerino, Francesco Bruno, Alessandro Mauro, Roberta Ruda
Summary: Research on brain damage mechanisms following radiation treatments for brain tumors has increased, providing insight into pathobiological mechanisms and suggesting new approaches to minimize damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Andrea Turolla, Raffaella Sabatino, Diego Fontaneto, Ester M. Eckert, Noemi Colinas, Gianluca Corno, Barbara Citterio, Francesca Biavasco, Manuela Antonelli, Alessandro Mauro, Gianmarco Mangiaterra, Andrea Di Cesare