Journal
MOLECULAR THERAPY
Volume 18, Issue 10, Pages 1885-1890Publisher
CELL PRESS
DOI: 10.1038/mt.2010.139
Keywords
-
Categories
Funding
- NIH [GM085793, CA103698, CA97762]
- Clayton Foundation for Research
- Retina Research Foundation
- Golfers Against Cancer
- Howard Hughes Medical Institutes Med Into Grad Initiative
Ask authors/readers for more resources
The ocular environment has been shown to induce tolerance to locally administered antigens. We therefore investigated whether there was a systemic immune response against adenoviral vectors injected into the vitreous of retinoblastoma patients enrolled in a phase 1 clinical trial of adenoviral-mediated thymidine kinase gene transfer. Sections of enucleated eyes were immuno-stained with antibodies against inflammatory cells. A trend toward increasing numbers of plasma cells, T cells, macrophages, and antigen-presenting cells was observed in the injected subjects' eyes, but systemically, there was no significant increase in the number of adenovirus-specific cytotoxic T lymphocytes (CTLs) or in adenovirus neutralizing antibodies. Therefore, in contrast to studies showing significant immunogenicity of Ad-RSVtk following injection into extraocular tumors, injection into the eye produces only a mild local inflammatory response without evidence of systemic cellular or humoral immune responses to adenovirus.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available