A competitive protein interaction network buffers Oct4-mediated differentiation to promote pluripotency in embryonic stem cells

Reduced Oct4 Expression Directs a Robust Pluripotent State with Distinct Signaling Activity and Increased Enhancer Occupancy by Oct4 and Nanog

(2013) Violetta Karwacki-Neisius et al.   Cell Stem Cell

A membrane-associated  -catenin/Oct4 complex correlates with ground-state pluripotency in mouse embryonic stem cells

(2013) F. Faunes et al.   DEVELOPMENT

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency

(2013) Yael Costa et al.   NATURE

A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages

(2013) Aliaksandra Radzisheuskaya et al.   NATURE CELL BIOLOGY

Glycogen Synthase Kinase-3 Inhibition Enhances Translation of Pluripotency-Associated Transcription Factors to Contribute to Maintenance of Mouse Embryonic Stem Cell Self-Renewal

(2013) Yolanda Sanchez-Ripoll et al.   PLoS One

Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells

(2013) Akira Nishiyama et al.   Scientific Reports

Regulation of Tcf7l1 DNA Binding and Protein Stability as Principal Mechanisms of Wnt/β-Catenin Signaling

(2013) Brian R. Shy et al.   Cell Reports

Regulation of Pluripotency and Cellular Reprogramming by the Ubiquitin-Proteasome System

(2012) Shannon M. Buckley et al.   Cell Stem Cell

Esrrb Is a Direct Nanog Target Gene that Can Substitute for Nanog Function in Pluripotent Cells

(2012) Nicola Festuccia et al.   Cell Stem Cell

Esrrb Is a Pivotal Target of the Gsk3/Tcf3 Axis Regulating Embryonic Stem Cell Self-Renewal

(2012) Graziano Martello et al.   Cell Stem Cell

A continuum of transcriptional identities visualized by combinatorial fluorescent in situ hybridization

(2012) L. M. Jakt et al.   DEVELOPMENT

Differential requirements for  -catenin during mouse development

(2012) S. Rudloff et al.   DEVELOPMENT

Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells

(2012) M. Iwafuchi-Doi et al.   DEVELOPMENT

OCT4/SOX2-independentNanogautorepression modulates heterogeneousNanoggene expression in mouse ES cells

(2012) Pablo Navarro et al.   EMBO JOURNAL

Cell signalling regulates dynamics of Nanog distribution in embryonic stem cell populations

(2012) Y. Luo et al.   Journal of the Royal Society Interface

Control of ground-state pluripotency by allelic regulation of Nanog

(2012) Yusuke Miyanari et al.   NATURE

Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming

(2012) M. Fidalgo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlations Between the Levels of Oct4 and Nanog as a Signature for Naïve Pluripotency in Mouse Embryonic Stem Cells

(2012) Silvia Muñoz Descalzo et al.   STEM CELLS

Control of the Embryonic Stem Cell State

(2011) Richard A. Young   CELL

Oct4 links multiple epigenetic pathways to the pluripotency network

(2011) Junjun Ding et al.   CELL RESEARCH

β-Catenin Enhances Oct-4 Activity and Reinforces Pluripotency through a TCF-Independent Mechanism

(2011) Kevin F. Kelly et al.   Cell Stem Cell

A Precarious Balance: Pluripotency Factors as Lineage Specifiers

(2011) Kyle M. Loh et al.   Cell Stem Cell

Gene expression heterogeneities in embryonic stem cell populations: origin and function

(2011) Alfonso Martinez Arias et al.   CURRENT OPINION IN CELL BIOLOGY

Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation

(2011) Natalia Lyashenko et al.   NATURE CELL BIOLOGY

Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal

(2011) Fei Yi et al.   NATURE CELL BIOLOGY

Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation

(2011) Jason Wray et al.   NATURE CELL BIOLOGY

A PiggyBac-Based Recessive Screening Method to Identify Pluripotency Regulators

(2011) Ge Guo et al.   PLoS One

The ground state of pluripotency

(2010) Jason Wray et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells

(2010) Debbie L.C. van den Berg et al.   Cell Stem Cell

Nanog Overcomes Reprogramming Barriers and Induces Pluripotency in Minimal Conditions

(2010) Thorold W. Theunissen et al.   CURRENT BIOLOGY

Oct-3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/β-catenin signalling

(2010) Monther Abu-Remaileh et al.   EMBO JOURNAL

Nanog Is the Gateway to the Pluripotent Ground State

(2009) Jose Silva et al.   CELL

Uncovering Early Response of Gene Regulatory Networks in ESCs by Systematic Induction of Transcription Factors

(2009) Akira Nishiyama et al.   Cell Stem Cell

A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells

(2009) Hitoshi Niwa et al.   NATURE

Regulated Fluctuations in Nanog Expression Mediate Cell Fate Decisions in Embryonic Stem Cells

(2009) Tibor Kalmar et al.   PLOS BIOLOGY

Capturing Pluripotency

(2008) Jose Silva et al.   CELL

A Hierarchical Network Controls Protein Translation during Murine Embryonic Stem Cell Self-Renewal and Differentiation

(2008) Prabha Sampath et al.   Cell Stem Cell

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE

Tcf3 Functions as a Steady-State Limiter of Transcriptional Programs of Mouse Embryonic Stem Cell Self-Renewal

(2008) Fei Yi et al.   STEM CELLS

Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition

(2008) Jose Silva et al.   PLOS BIOLOGY