Biomedically relevant circuit-design strategies in mammalian synthetic biology

mRNA transfection-based, feeder-free, induced pluripotent stem cells derived from adipose tissue of a 50-year-old patient

(2013) Boon Chin Heng et al.   METABOLIC ENGINEERING

Autonomous bacterial localization and gene expression based on nearby cell receptor density

(2013) H.-C. Wu et al.   Molecular Systems Biology

Synthetic analog computation in living cells

(2013) Ramiz Daniel et al.   NATURE

Optogenetic protein clustering and signaling activation in mammalian cells

(2013) Lukasz J Bugaj et al.   NATURE METHODS

A red/far-red light-responsive bi-stable toggle switch to control gene expression in mammalian cells

(2013) Konrad Müller et al.   NUCLEIC ACIDS RESEARCH

Multi-chromatic control of mammalian gene expression and signaling

(2013) Konrad Müller et al.   NUCLEIC ACIDS RESEARCH

Synthetic biology, the bioeconomy, and a societal quandary

(2013) Jim C. Philp et al.   TRENDS IN BIOTECHNOLOGY

Synthetic biology: from hype to impact

(2013) Timothy S. Gardner   TRENDS IN BIOTECHNOLOGY

Synthetic Biology: Advancing the Design of Diverse Genetic Systems

(2013) Yen-Hsiang Wang et al.   Annual Review of Chemical and Biomolecular Engineering

Light activated cell migration in synthetic extracellular matrices

(2012) Qiongyu Guo et al.   BIOMATERIALS

Towards synthetic microbial consortia for bioprocessing

(2012) Jasmine Shong et al.   CURRENT OPINION IN BIOTECHNOLOGY

Synthetic biology advancing clinical applications

(2012) Marc Folcher et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Explaining life

(2012) Anna Deplazes-Zemp et al.   EMBO REPORTS

Synthetic memory circuits for tracking human cell fate

(2012) D. R. Burrill et al.   GENES & DEVELOPMENT

Light-Inducible Spatiotemporal Control of Gene Activation by Customizable Zinc Finger Transcription Factors

(2012) Lauren R. Polstein et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells

(2012) Ping Wei et al.   NATURE

Genetic programs constructed from layered logic gates in single cells

(2012) Tae Seok Moon et al.   NATURE

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

(2012) Dipesh Chaudhury et al.   NATURE

Synthetic two-way communication between mammalian cells

(2012) William Bacchus et al.   NATURE BIOTECHNOLOGY

The new drug circuit

(2012) Daniel Grushkin   NATURE MEDICINE

Let's start talking

(2012) Nicole Rusk   NATURE METHODS

TULIPs: tunable, light-controlled interacting protein tags for cell biology

(2012) Devin Strickland et al.   NATURE METHODS

Spatiotemporal control of gene expression by a light-switchable transgene system

(2012) Xue Wang et al.   NATURE METHODS

Streamlined engineering for synthetic biology

(2012) Jeffrey M Perkel   NATURE METHODS

Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome

(2012) H. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radio-Wave Heating of Iron Oxide Nanoparticles Can Regulate Plasma Glucose in Mice

(2012) S. A. Stanley et al.   SCIENCE

Optical Control of Protein Activity by Fluorescent Protein Domains

(2012) X. X. Zhou et al.   SCIENCE

Distributed computation: the new wave of synthetic biology devices

(2012) Javier Macía et al.   TRENDS IN BIOTECHNOLOGY

From gene switches to mammalian designer cells: present and future prospects

(2012) Simon Ausländer et al.   TRENDS IN BIOTECHNOLOGY

Engineering Molecular Circuits Using Synthetic Biology in Mammalian Cells

(2012) Markus Wieland et al.   Annual Review of Chemical and Biomolecular Engineering

Modular Design of Artificial Tissue Homeostasis: Robust Control through Synthetic Cellular Heterogeneity

(2012) Miles Miller et al.   PLoS Computational Biology

Engineered cell-cell communication via DNA messaging

(2012) Monica E Ortiz et al.   Journal of Biological Engineering

Microbial linguistics: perspectives and applications of microbial cell-to-cell communication

(2011) Robert J. Mitchell et al.   BMB Reports

Smart medication through combination of synthetic biology and cell microencapsulation

(2011) Simon Ausländer et al.   METABOLIC ENGINEERING

Virally delivered Channelrhodopsin-2 Safely and Effectively Restores Visual Function in Multiple Mouse Models of Blindness

(2011) M Mehdi Doroudchi et al.   MOLECULAR THERAPY

Synthetic biology: Division of logic labour

(2011) Bochong Li et al.   NATURE

A sensing array of radically coupled genetic ‘biopixels’

(2011) Arthur Prindle et al.   NATURE

In silico feedback for in vivo regulation of a gene expression circuit

(2011) Andreas Milias-Argeitis et al.   NATURE BIOTECHNOLOGY

DNA computes a square root

(2011) Yaakov Benenson   Nature Nanotechnology

Function, structure and mechanism of bacterial photosensory LOV proteins

(2011) Julien Herrou et al.   NATURE REVIEWS MICROBIOLOGY

Synthetic Physiology

(2011) B. Y. Chow et al.   SCIENCE

Sequential Establishment of Stripe Patterns in an Expanding Cell Population

(2011) C. Liu et al.   SCIENCE

Synthetic Biology Moving into the Clinic

(2011) W. C. Ruder et al.   SCIENCE

A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice

(2011) H. Ye et al.   SCIENCE

Multi-Input RNAi-Based Logic Circuit for Identification of Specific Cancer Cells

(2011) Z. Xie et al.   SCIENCE

A designer network coordinating bovine artificial insemination by ovulation-triggered release of implanted sperms

(2010) Christian Kemmer et al.   JOURNAL OF CONTROLLED RELEASE

Toward the Second Generation of Optogenetic Tools

(2010) T. Knopfel et al.   JOURNAL OF NEUROSCIENCE

A tunable dual-promoter integrator for targeting of cancer cells

(2010) Lior Nissim et al.   Molecular Systems Biology

Distributed biological computation with multicellular engineered networks

(2010) Sergi Regot et al.   NATURE

Robust multicellular computing using genetically encoded NOR gates and chemical ‘wires’

(2010) Alvin Tamsir et al.   NATURE

High-performance genetically targetable optical neural silencing by light-driven proton pumps

(2010) Brian Y. Chow et al.   NATURE

Self-sufficient control of urate homeostasis in mice by a synthetic circuit

(2010) Christian Kemmer et al.   NATURE BIOTECHNOLOGY

Optogenetic control of heart muscle in vitro and in vivo

(2010) Tobias Bruegmann et al.   NATURE METHODS

Rapid blue-light–mediated induction of protein interactions in living cells

(2010) Matthew J Kennedy et al.   NATURE METHODS

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

An engineered mammalian band-pass network

(2010) D. Greber et al.   NUCLEIC ACIDS RESEARCH

Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems

(2010) Y. Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model

(2010) F. Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reprogramming Cellular Behavior with RNA Controllers Responsive to Endogenous Proteins

(2010) S. J. Culler et al.   SCIENCE

Optogenetic Control of Cardiac Function

(2010) A. B. Arrenberg et al.   SCIENCE

Regulating Ethical Issues in Cell-Based Interventions: Lessons from Universal Declaration on Bioethics and Human Rights

(2009) Ana Rosa Tenório de Amorim   AMERICAN JOURNAL OF BIOETHICS

Resistance to Diet-Induced Obesity in Mice with Synthetic Glyoxylate Shunt

(2009) Jason T. Dean et al.   Cell Metabolism

A synthetic metabolite-based mammalian inter-cell signaling system

(2009) Wilfried Weber et al.   Molecular BioSystems

Photon capture and signalling by melanopsin retinal ganglion cells

(2009) Michael Tri H. Do et al.   NATURE

Spatiotemporal control of cell signalling using a light-switchable protein interaction

(2009) Anselm Levskaya et al.   NATURE

Temporally precise in vivo control of intracellular signalling

(2009) Raag D. Airan et al.   NATURE

A genetically encoded photoactivatable Rac controls the motility of living cells

(2009) Yi I. Wu et al.   NATURE

A tunable synthetic mammalian oscillator

(2009) Marcel Tigges et al.   NATURE

Induction of protein-protein interactions in live cells using light

(2009) Masayuki Yazawa et al.   NATURE BIOTECHNOLOGY

Spatiotemporal modulation of biodiversity in a synthetic chemical-mediated ecosystem

(2009) Hao Song et al.   Nature Chemical Biology

Timing Cellular Decision Making Under Noise via Cell–Cell Communication

(2009) Aneta Koseska et al.   PLoS One

Higher plants use LOV to perceive blue light

(2008) Emilie Demarsy et al.   CURRENT OPINION IN PLANT BIOLOGY

A synthetic Escherichia coli predator–prey ecosystem

(2008) Frederick K Balagaddé et al.   Molecular Systems Biology

Drug-sensing hydrogels for the inducible release of biopharmaceuticals

(2008) Martin Ehrbar et al.   NATURE MATERIALS

Intronically encoded siRNAs improve dynamic range of mammalian gene regulation systems and toggle switch

(2008) D. Greber et al.   NUCLEIC ACIDS RESEARCH

A synthetic mammalian gene circuit reveals antituberculosis compounds

(2008) W. Weber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The phytochrome red/far-red photoreceptor superfamily

(2008) Robert A Sharrock   GENOME BIOLOGY

Construction of an artificial intercellular communication network using the nitric oxide signaling elements in mammalian cells

(2007) Wei-Dong Wang et al.   EXPERIMENTAL CELL RESEARCH