Article
Fisheries
Feiyan Meng, Shu Sun, Xing Xu, Weixing Yu, Riping Gan, Lihong Zhang, Weimin Zhang
Summary: The study investigates the regulation of oocyte growth and maturation in the ricefield eel, which has become an important aquaculture species in China. The researchers classified the development of ricefield eel ovarian follicles into nine stages and performed transcriptomic analysis on isolated ovarian follicles from different stages. The study identifies several genes and pathways that may be involved in oocyte growth and maturation in ricefield eels.
Article
Biochemistry & Molecular Biology
Nina M. Alyoshina, Maria D. Tkachenko, Lyudmila A. Malchenko, Yuri B. Shmukler, Denis A. Nikishin
Summary: Serotonin plays a crucial role in regulating female reproductive function in mammalian ovaries, with the involvement of serotonin transporter and monoamine oxidase. The accumulation of serotonin is more effective in denuded oocytes and hindered by granulosa cells surrounding the oocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Emily J. Zaniker, Elnur Babayev, Francesca E. Duncan
Summary: Ovulation is a fundamental biological event that involves the rupture of follicle wall and release of mature egg. This process is driven by proteolytic and inflammatory pathways, as well as structural alterations to the vasculature and cavity of the follicle. Comparisons with other rupture events, such as intracranial aneurysms and chorioamniotic membrane rupture, reveal common processes and differentially expressed genes. Understanding the physiology of ovulation through analysis of transcriptomic data and experimental techniques from studies of rupture in other biological systems can provide insights for future studies and novel targets in the field of reproductive biology.
BIOLOGICAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Alba Ferre, Francois Chauvigne, Anna Vlasova, Birgitta Norberg, Luca Bargelloni, Roderic Guigo, Roderick Nigel Finn, Joan Cerda
Summary: The aquaporin-mediated oocyte hydration plays a crucial role in the evolution of pelagic eggs and the success of marine teleosts. However, the molecular regulatory mechanisms controlling this process have not been fully understood. Through analyzing over 400 piscine genomes, researchers discovered a teleost-specific aquaporin-1 cluster (TSA1C) consisting of aqp1aa-aqp1ab2-aqp1ab1 genes. Evolutionary analysis revealed that marine species with highly hydrated pelagic eggs retained at least one downstream paralog, and a significant portion of modern marine teleosts retained both aqp1ab-type channels and co-evolved regulatory proteins for membrane trafficking. The selective advantages of these mechanisms were demonstrated to accelerate hydration and facilitate geodispersal in oceanic currents.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Article
Pharmacology & Pharmacy
Selva Nataraja, Henry Yu, Joie Guner, Stephen Palmer
Summary: The passage discusses two oral follicle-stimulating hormone receptor allosteric agonists that show promising pharmacology and safety profiles for treating infertility in women. These compounds offer a more convenient treatment option and have demonstrated efficacy in preclinical studies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Orthopedics
Aaron M. Gazendam, Patricia Schneider, Mohit Bhandari, Jason W. Busse, Michelle Ghert
Summary: This study determined the minimally important differences (MIDs) for Musculoskeletal Tumor Society Rating Scale-93 (MSTS-93) and Toronto Extremity Salvage Score (TESS) in patients undergoing lower-extremity endoprosthetic reconstruction for musculoskeletal tumors. Two methods, anchor-based and distribution-based, yielded different results, but anchor-based MIDs were recommended.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Review
Cell Biology
D. R. Nascimento, E. C. Barbalho, L. Gondim Barrozo, E. I. T. de Assis, F. C. Costa, J. R. V. Silva
Summary: The transition from preantral to early antral follicles is a complex process regulated by endocrine and paracrine factors, as well as by interactions among oocyte, granulosa cells, and theca cells. Understanding the mechanisms that control this transition is important for improving in vitro culture systems and utilizing oocytes from preantral follicles in assisted reproductive technologies. This review discusses the endocrine and paracrine mechanisms involved in granulosa cell proliferation and differentiation, antral cavity formation, estradiol production, atresia, and follicular fluid production during this transition. The strategies for promoting in vitro growth of preantral follicles are also explored.
Article
Green & Sustainable Science & Technology
Anna Furberg, Rickard Arvidsson, Sverker Molander
Summary: In comparative life cycle assessment studies of materials, there is a discrepancy between current practices and existing guidelines for defining functional units. This study introduces three types of functional units: reference flow, property, and performance functional units. Different types of functional units are suitable for different research goals, but achieving complete functional equivalence in practice is challenging.
JOURNAL OF INDUSTRIAL ECOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
F. T. G. Bezerra, A. M. P. Dau, R. Van Den Hurk, J. R. V. Silva
Summary: In vitro research has made significant advances in predicting antral follicle growth and oocyte maturation, with a focus on the roles of cumulus and mural granulosa cells. Differences in gene expression in small and large follicles impact the success of in vitro blastocyst development, while molecular mechanisms related to COC metabolism and antioxidant defense are highlighted as crucial for oocyte competence. New insights and perspectives on the molecular and cellular regulation of in vitro oocyte maturation are emphasized.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Valentina Lodde, Alberto Maria Luciano, Giulia Musmeci, Ileana Miclea, Irene Tessaro, Mariella Aru, David F. Albertini, Federica Franciosi
Summary: Women's reproductive performance declines starting in midlife, with a very low possibility of pregnancy by age 40-45. Premature ovarian failure and early ovarian aging can lead to low-quality eggs, impacting fertility. Understanding cellular mechanisms is essential for finding solutions to reproductive aging issues.
Article
Ecology
Kezia Manlove, Mark Wilber, Lauren White, Guillaume Bastille-Rousseau, Anni Yang, Marie L. J. Gilbertson, Meggan E. Craft, Paul C. Cross, George Wittemyer, Kim M. Pepin
Summary: Pathogen transmission is influenced by host density, mobility, and contact, which are influenced by host and pathogen movements and their interactions with the surrounding environment.
Article
Pharmacology & Pharmacy
Carmen Alvarez-Lorenzo, Maria Vivero-Lopez, Angel Concheiro
Summary: This study demonstrates the spontaneous formation of anisotropic gold nanoparticles (AuNPs) inside preformed contact lenses (CLs) without the need for additional reductant agents. The formation of AuNPs was achieved through a precise tuning of the monomeric composition, saline concentration, and the use of steam heat sterilization. The potential applications of incorporating AuNPs in CLs in the ocular field for prophylaxis, therapy, and diagnosis are highlighted. The developed CLs also exhibit photoresponsiveness and efficient filtering of highly penetrant light.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Multidisciplinary Sciences
Jinyuan Hu, Junhui Li, Jennifer Jiang, Lingling Wang, Jonathan Roth, Kenneth N. McGuinness, Jean Baum, Wei Dai, Yao Sun, Vikas Nanda, Fei Xu
Summary: Collagens are essential for mediating cell-matrix interactions and tissue mechanics. Synthetic collagens that mimic the structure and properties of natural collagen have been developed, and they could serve as safe and functional biomaterials for various applications.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Zhuo Wan, Edmund T. Rolls, Jianfeng Feng, Wei Cheng
Summary: Childhood traumatic events are significantly associated with adult mental health problems and cognitive performance, which may be mediated by brain functional connectivities in areas involved in executive function, emotion, face processing, and memory. This understanding is important for prevention and treatment.
Article
Oncology
Claudia Regis, Marie-Cecile Le Deley, Emilie Bogart, Clemence Leguillette, Loic Boulanger, Marie-Pierre Chauvet, Romain Viard, Julien Thery, Romain Bosc, Christine Delmaire
Summary: This study used functional magnetic resonance imaging to investigate the body map integration of different types of breast reconstruction procedures. The results showed that regardless of the type or timing of breast reconstruction, the reconstructed breast is integrated into the body schema.
ANNALS OF SURGICAL ONCOLOGY
(2022)