Journal
MOLECULAR REPRODUCTION AND DEVELOPMENT
Volume 79, Issue 11, Pages 742-756Publisher
WILEY
DOI: 10.1002/mrd.22078
Keywords
fertilization; oocyte; calcium influx; SOCE; CaMKII
Funding
- Intramural Research Program of the NIH
- National Institutes of Environmental Health Sciences [Z01ES102985]
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Calcium (Ca2+) signals drive the fundamental events surrounding fertilization and the activation of development in all species examined to date. Initial studies of Ca2+ signaling at fertilization in marine animals were tightly linked to new discoveries of bioluminescent proteins and their use as fluorescent Ca2+ sensors. Since that time, there has been rapid progress in our understanding of the key functions for Ca2+ in many cell types and of the impact of cellular localization on Ca2+ signaling pathways. In this review, which focuses on mammalian egg activation, we consider how Ca2+ is regulated and stored at different stages of oocyte development and examine the functions of molecules that serve as both regulators of Ca2+ release and effectors of Ca2+ signals. We then summarize studies exploring how Ca2+ directs downstream effectors mediating both egg activation and later signaling events required for successful preimplantation embryo development. Throughout this review, we focus attention on how localization of Ca2+ signals influences downstream signaling events, and attempt to highlight gaps in our knowledge that are ripe for future research. Mol. Reprod. Dev. 79: 742756, 2012. Published 2012. This article is a US government work and, as such, is in the public domain in the United States of America.
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