Article
Immunology
Dilay Cansever, Ekaterina Petrova, Sinduya Krishnarajah, Caroline Mussak, Christina A. Welsh, Wiebke Mildenberger, Kevin Mulder, Victor Kreiner, Elsa Roussel, Sebastian A. Stifter, Myrto Andreadou, Pascale Zwicky, Nicole Puertas Jurado, Hubert Rehrauer, Ge Tan, Zhaoyuan Liu, Camille Bleriot, Francesca Ronchi, Andrew J. Macpherson, Florent Ginhoux, Giancarlo Natalucci, Burkhard Becher, Melanie Greter
Summary: Macrophages play a role in immune defense, organogenesis, and tissue homeostasis. During lactation, a unique population of macrophages called liMacs emerges in the mammary gland and milk, which is similar to macrophages found in human milk.
Article
Cell Biology
Dan Li, Mingjun San, Jing Zhang, Anlan Yang, Wanhua Xie, Yang Chen, Xiaodan Lu, Yuntao Zhang, Mingyue Zhao, Xuechao Feng, Yaowu Zheng
Summary: The study using a transgenic mouse model of OXTR overexpression found that OXTR can promote mammary hyperplasia and tumorigenesis, as well as creating a microenvironment that promotes tumor growth, providing potential for targeted therapy in HER2-type breast cancer.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Multidisciplinary
Yusaku Tsugami, Haruka Wakasa, Takanori Nishimura, Ken Kobayashi
Summary: Genistein is able to directly inhibit the phosphorylation of STAT5 in lactating MECs, independent of the phosphorylation of EGFR.
Article
Biochemistry & Molecular Biology
Lilia Sanchez, Jessica Epps, Steven Wall, Cole McQueen, Scott J. Pearson, Kelly Scribner, Elizabeth A. Wellberg, Erin D. Giles, Monique Rijnkels, Weston W. Porter
Summary: The functionally differentiated mammary gland adapts to extreme levels of stress by activating specific protective mechanisms. The breast tumor suppressor gene SIM2s is identified as a novel regulator of mitophagy, a key component of this stress response.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Multidisciplinary Sciences
Alecia-Jane Twigger, Lisa K. Engelbrecht, Karsten Bach, Isabel Schultz-Pernice, Sara Pensa, Jack Stenning, Stefania Petricca, Christina H. Scheel, Walid T. Khaled
Summary: This study characterizes cells in human milk and identifies epithelial cells similar to luminal progenitors and immune cells. The findings contribute to understanding the remodelling of human mammary tissue during pregnancy and lactation, and provide insights into the interplay between pregnancy, lactation, and breast cancer.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Zhiyun Hao, Yuzhu Luo, Jiqing Wang, Jon G. H. Hickford, Huitong Zhou, Jiang Hu, Xiu Liu, Shaobin Li, Jiyuan Shen, Na Ke, Weiwei Liang, Zhaochun Huang
Summary: The study demonstrated that miR-432 inhibits the proliferation of OMECs by targeting the genes SCD and LPL involved in milk fat synthesis. Transfection with miR-432 mimic reduced the expression of milk fat synthesis marker genes and triglyceride content in OMECs, while miR-432 inhibitor had the opposite effect. This study provides insights into the biological mechanisms of miR-432 in inhibiting milk fat synthesis in sheep.
Article
Agriculture, Dairy & Animal Science
Christina Bradshaw, Aridany Suarez Trujillo, Sarah M. Luecke, Lea D. Logan, Rodrigo Mohallem, Uma K. Aryal, Kara R. Stewart, Theresa M. Casey, Radiah C. Minor
Summary: The composition of milk in swine lactation changes significantly across the three phases, with the highest levels of fat and lactose in the early transitional period, and a significant decrease in protein content in colostrum. Proteomic analysis reveals specific proteins that vary in abundance throughout lactation, potentially reflecting mammary function and developmental needs of the neonate.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Doreen Becker, Rosemarie Weikard, Frieder Hadlich, Christa Kuehn
Summary: The analysis of single-cell RNA datasets from bovine milk cells and pbMECs revealed distinct clusters within each population, indicating heterogeneity between the populations. These datasets provide a molecular cell atlas for future studies of milk cell composition and gene expression.
Article
Nutrition & Dietetics
Min Fu, Yuanpeng Gao, Wenxing Guo, Qi Meng, Qi Jin, Rui Yang, Ying Yang, Yaqi Zhang, Wanqi Zhang
Summary: This research investigates the compensation mechanism of iodine deficiency and excess in the mammary gland during lactation. The study found that milk iodine concentration is positively correlated with iodine intake, and the regulation of glycosylation and degradation of NIS by DPAGT1 and VCP in the mammary gland plays a role in regulating milk iodine level. However, the mammary gland has limited ability to compensate for iodine deficiency and excess.
Article
Biochemistry & Molecular Biology
Catalina A. Pomar, Pedro Castillo, Andreu Palou, Mariona Palou, Catalina Pico
Summary: This study aimed to evaluate the impact of improving maternal nutrition during lactation on the levels of specific miRNA in the mammary gland and milk of diet-induced obese rats. The results showed that implementing a healthy diet during lactation can normalize the expression levels of specific miRNA and some target genes in the mammary gland of obese dams but not in milk.
Article
Agriculture, Dairy & Animal Science
Jinbo Wu, Shiming He, Zhonghua Yu, Daoliang Lan, Xianrong Xiong, Zhu Li
Summary: In this study, RNA-seq was used to analyze the mammary gland transcriptomes of high-yielding and low-yielding yaks during lactation. The results showed that 144 differential genes were identified, which were involved in various biological processes such as carbohydrate metabolism. This study provides new insights into the molecular mechanism of yak mammary gland tissue and potential strategies for improving milk production in yaks.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rong Xuan, Jianmin Wang, Qing Li, Yanyan Wang, Shanfeng Du, Qingling Duan, Yanfei Guo, Peipei He, Zhibin Ji, Tianle Chao
Summary: This study conducted transcriptome sequencing of goat-mammary-gland tissue at different developmental stages to reveal the expression characteristics and molecular functions of circRNAs during mammary involution. A total of 11,756 circRNAs were identified, with 2528 circRNAs expressed in all three stages. Gene ontology analysis showed functional diversity of circRNAs' source genes. Furthermore, differentially expressed circRNAs and circRNA-miRNA-mRNA ceRNA regulatory networks were identified, providing insights into the regulatory role of circRNAs in mammary cell involution and remodeling.
Article
Agriculture, Dairy & Animal Science
Wei Xia, Yili Liu, Juan J. Loor, Massimo Bionaz, Mingfeng Jiang
Summary: This study evaluated the transcriptome of mammary tissue in four yaks throughout the lactation cycle. The analysis identified over 6000 differentially expressed genes, with a large number of genes showing differential expression at the onset and end of lactation. The functions affected by transcriptomic adaptation to lactation in yak mammary tissue were similar to those observed in dairy cows, including induction of lipid metabolism, amino acid metabolism, and glycan biosynthesis, as well as suppression of the cell cycle and immune response.
Article
Cell Biology
Ivan Luzardo-Ocampo, Jose L. Dena-Beltran, Xarubet Ruiz-Herrera, Ana Luisa Ocampo-Ruiz, Gonzalo Martinez de la Escalera, Carmen Clapp, Yazmin Macotela
Summary: Obesity is a modern pandemic that negatively impacts women's reproductive health. Women with obesity experience changes in their mammary glands which affect their ability to exclusively breastfeed. The hormone prolactin, which is responsible for lactation, has reduced activity in the mammary glands of obese lactating rodents, contributing to impaired lactation. Treatment with prolactin has shown to improve milk production in women with inadequate lactation. This review focuses on the effects of diet-induced obesity on lactating mammary glands and how obesity impairs the lactogenic action of prolactin. While the impact of obesity on lactation has been studied in both humans and rodents, most of the research has been conducted on rodents.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Review
Genetics & Heredity
Cathy Hue-Beauvais, Yannick Faulconnier, Madia Charlier, Christine Leroux
Summary: This review article discusses the impact of nutrition on mammary development and milk synthesis in mammals, highlighting the importance of nutrition on milk quality and quantity. It also explores the effects of dietary alterations during lactation and the implications for gene expression involved in milk biosynthesis.
Article
Oncology
Moshe Reichenstein, Gat Rauner, Shenhav Kfir, Tatiana Kisliouk, Itamar Barash
Article
Biochemistry & Molecular Biology
M Reichenstein, T German, I Barash
Article
Biotechnology & Applied Microbiology
M Cohen, M Reichenstein, A Everts-van der Wind, J Heon-Lee, M Shani, HA Lewin, JI Weller, M Ron, E Seroussi
Article
Cell Biology
M Reichenstein, R Reich, JG LeHoux, I Hanukoglu
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2004)
Article
Biochemistry & Molecular Biology
JP Renou, B Bierie, K Miyoshi, YZ Cui, J Djiane, M Reichenstein, M Shani, L Hennighausen
Article
Endocrinology & Metabolism
K Miyoshi, B Meyer, P Gruss, YZ Cui, JP Renou, FV Morgan, GH Smith, M Reichenstein, M Shani, L Hennighausen, GW Robinson
MOLECULAR ENDOCRINOLOGY
(2002)
Article
Biochemistry & Molecular Biology
I Barash, M Reichenstein
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2002)