Article
Endocrinology & Metabolism
Xingyi Zhao, Minpeng Ji, Xin Wen, Dan Chen, Fu Huang, Xiaoju Guan, Jing Tian, Jiajia Xie, Jingjing Shao, Jiexia Wang, Luoqi Huang, Han Lin, Leping Ye, Haolin Chen
Summary: Midazolam has dose-dependent effects on Leydig cell differentiation, with low concentrations increasing testosterone production and high concentrations inhibiting Leydig cell development. Uneven changes in steroidogenic pathway proteins, especially reductions in CYP17A1 at high midazolam levels, may lead to an accumulation of progesterone, potentially impacting male reproduction. Further studies are needed to assess the effects of midazolam on human cells.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Reproductive Biology
Xiaodan Li, Xiaolei Yao, Haiqiang Xie, Mingtian Deng, Xiaoxiao Gao, Kaiping Deng, Yongjin Bao, Qi Wang, Feng Wang
Summary: This study revealed that SPATA6 is highly expressed in the testis of Hu sheep and localized in LCs and spermatogenic cells. SPATA6 plays a key role in regulating the proliferation, apoptosis, and testosterone biosynthesis of LCs, contributing to sheep spermatogenesis.
Article
Developmental Biology
Xiaoqin Li, Zhilan Lu, Xiushuai Du, Youbin Ye, Jianlin Zhu, Yuchen Li, Jin Liu, Wenchang Zhang
Summary: Exposure to cadmium during pregnancy can have inter-generational effects on male reproduction, particularly by causing toxicity in Sertoli cells. This effect appears to be primarily mediated through disruptions in the FSHR pathway and changes in DNA methyltransferase activity. Distinct patterns and inconsistencies were observed between the F1 and F2 generations.
Article
Obstetrics & Gynecology
Zhanhui Ou, Jing Du, Nengqing Liu, Jieliang Li, Xiufeng Lin
Summary: This study aimed to investigate the impact of a reduced dose of follicle-stimulating hormone (FSH) before human chorionic gonadotropin (hCG) trigger on in vitro fertilization (IVF) outcomes. Compared to the group that did not receive a reduced dose of FSH, the group with reduced dose experienced lower estrogen (E2) and progesterone (P) levels on the day of hCG trigger and had a higher fresh embryo-transfer cycle rate. However, the reduced dose of FSH did not significantly affect the number of retrieved oocytes, total number of mature oocytes, fertilization rate, cleavage rate, quality rate on Day 3, implantation rate, pregnancy rate per cycle, and early pregnancy loss rate.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Pharmacology & Pharmacy
Guoping Li, Xiuting Chang, Yingshu Zhao, Daoyuan Li, Xinli Kang
Summary: The study showed that exposure to DBT in vitro inhibited androgen production in immature Leydig cells by affecting gene expression and enzyme activities. Specifically, DBT was found to directly inhibit the activities of CYP11A1 and 3β-HSD1 enzymes.
Review
Obstetrics & Gynecology
Tilda Moberg, Lennart van der Veeken, Emma Persad, Stefan R. Hansson, Matteo Bruschettini
Summary: This systematic review aimed to investigate the potential correlation between nausea and vomiting in pregnancy (NVP) or hyperemesis gravidarum (HG) with adverse pregnancy outcomes and human chorionic gonadotropin (hCG) levels. The evidence suggests that women with HG may have an increased risk for preeclampsia, preterm delivery, small for gestational age, low birth weight, and a higher fetal female/male ratio. On the other hand, women with NVP may have a lower risk for preterm delivery and low birth weight, but a higher risk for small for gestational age and a higher fetal female/male ratio. However, the evidence for these conclusions is very uncertain.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Food Science & Technology
Lingwei Sun, Jianjun Dai, Jiehuan Xu, Junhua Yang, Defu Zhang
Summary: This study investigates the toxic effects and underlying mechanisms of mycotoxins such as zearalenone, deoxynivalenol, and T-2 toxin. The results indicate that these toxins cause reproductive toxicity by inhibiting steroidogenesis and cell proliferation, leading to cellular apoptosis.
Article
Environmental Sciences
Taherah Asmall, Amber Abrams, Martin Roosli, Gueladio Cisse, Kirsty Carden, Mohamed Aqiel Dalvie
Summary: The systematic review of epidemiological research on the health effects of drought in Africa from 2012 to 2019 revealed associations with adverse nutritional health, diseases from water contamination, and changes in health behaviors. Limited evidence was found for various health outcomes, with key areas identified for further research and considerations for interventions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Endocrinology & Metabolism
Jingjing Shao, Jiexia Wang, Xin Wen, Jiajia Xie, Fu Huang, Xiaoju Guan, Xinrui Hao, Ping Duan, Congde Chen, Haolin Chen
Summary: Aging and testicular macrophages may affect the function of stem Leydig cells, leading to a decrease in their numbers and a reduction in their differentiation ability.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Yuji Nozaki, Akiomi Yoshihisa, Yu Sato, Himika Ohara, Yukiko Sugawara, Satoshi Abe, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Kazuhiko Nakazato, Yasuchika Takeishi
Summary: Persistent hypochloremia in patients with heart failure is associated with an adverse prognosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Chemistry, Physical
Marianna Arakelyan, Gianrico Spagnuolo, Flavia Iaculli, Natalya Dikopova, Artem Antoshin, Peter Timashev, Anna Turkina
Summary: Metal alloys, commonly used in dental practice, may release metal ions into the oral cavity and cause adverse effects on surrounding tissues and internal organs. These effects include mouth burning, potentially malignant oral lesions, and local or systemic hypersensitivity. Clear diagnostic criteria and treatment guidelines are currently lacking.
Review
Psychiatry
Zhang Huashuang, Li Yang, Hou Chensheng, Xin Jing, Chen Bo, Zhang Dongming, Liang Kangfu, Wang Shi-Bin
Summary: This systematic review and meta-analysis evaluated the prevalence of adverse effects (AEs) related to transcranial magnetic stimulation (TMS) in autism spectrum disorder (ASD). The overall prevalence of reported AEs of TMS among ASD was 25%, with identified factors showing no significant change in overall prevalence of AEs. Further studies are recommended to clarify the variation in the prevalence.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Environmental Sciences
Alexander V. Sirotkin, Martina Macejkova, Adam Tarko, Zuzana Fabova, Saleh Alwasel, Abdel Halim Harrath
Summary: The study found that xylene suppresses ovarian cell functions, but buckwheat, rooibos, and vitex can mitigate these effects, acting as natural protectors against the adverse effects of xylene on ovarian cells.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Toxicology
Mathilde Munier, Mohammed Ayoub, Valentine Suteau, Louis Gourdin, Daniel Henrion, Eric Reiter, Patrice Rodien
Summary: This study found that p, p' DDT negatively affected cAMP production, beta-arrestin 2 recruitment, and steroid secretion induced by hCG or LH, acting as a negative allosteric modulator of the hCG/LHR signaling pathway.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zoheir B. Demmouche, Jacques J. Tremblay
Summary: Leydig cells produce testosterone, a hormone essential for male sex differentiation and spermatogenesis. LH stimulates testosterone production by activating various kinases and transcription factors through increasing cAMP levels. AMPK, activated by AMP, potently represses steroidogenesis. The study identifies global changes in protein and phosphoprotein levels during both the stimulatory and inhibitory phases of steroidogenesis, providing new insights into the finely tuned processes of adequate steroid hormone production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
