Article
Oncology
Sen Li, Chenyang Zhao, Jinlan Gao, Xinbin Zhuang, Shuang Liu, Xuesha Xing, Qi Liu, Chen Chen, Shusen Wang, Yang Luo
Summary: Cyclin G2 serves as a potent tumor suppressor in glioma by inhibiting tumor growth and promoting apoptosis. Its mechanism involves suppressing LDHA phosphorylation, reversing immunosuppression, and enhancing responses to immunotherapy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Immunology
Mahesh Raundhal, Shrestha Ghosh, Samuel A. Myers, Michael S. Cuoco, Meromit Singer, Steven A. Carr, Sushrut S. Waikar, Joseph Bonventre, Jerome Ritz, Richard M. Stone, David P. Steensma, Aviv Regev, Laurie H. Glimcher
Summary: The study reveals that haplosufficiency of the serine-threonine kinase RIOK2 leads to decreased erythroid precursor frequency and subsequent anemia, with IL-22 playing a crucial role in affecting erythroid precursors. Blocking IL-22 signaling alleviates anemia, suggesting a potential therapeutic target for stress-induced anemias. The findings also suggest that immune dysregulation is involved in the pathogenesis of myelodysplastic syndromes.
Review
Biochemistry & Molecular Biology
Chia-Jui Hsu, Lee-Chin Wong, Wang-Tso Lee
Summary: This review examines the clinical characteristics, clinical evidence, and genetic studies in vitro as well as animal studies regarding immune dysfunction in Tourette syndrome, suggesting that autoimmune dysfunction may play a significant role in the pathogenesis of Tourette syndrome and related neuropsychiatric disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Kevin Peikert, Enrica Federti, Alessandro Matte, Gabriela Constantin, Enrica Caterina Pietronigro, Paolo Francesco Fabene, Paola Defilippi, Emilia Turco, Federico Del Gallo, Pietro Pucci, Angela Amoresano, Anna Illiano, Flora Cozzolino, Maria Monti, Francesca Garello, Enzo Terreno, Seth Leo Alper, Hannes Glass, Lisann Pelzl, Katja Akguen, Tjalf Ziemssen, Rainer Ordemann, Florian Lang, Anna Maria Brunati, Elena Tibaldi, Immacolata Andolfo, Achille Iolascon, Giuseppe Bertini, Mario Buffelli, Carlo Zancanaro, Erika Lorenzetto, Angela Siciliano, Massimiliano Bonifacio, Adrian Danek, Ruth Helen Walker, Andreas Hermann, Lucia De Franceschi
Summary: Chorea-Acanthocytosis (ChAc) is a neurodegenerative disease caused by VPS13A mutations. Inhibition of Lyn kinase can alleviate ChAc symptoms, making it a potential therapeutic option.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Paola Imbriani, Giuseppe Sciamanna, Ilham El Atiallah, Silvia Cerri, Ellen J. Hess, Antonio Pisani
Summary: Alcohol consumption affects motor behavior and control, but the therapeutic mechanism for movement disorders like myoclonus-dystonia remains unclear, with few systematic trials on GABA drugs mimicking alcohol effects. This survey aims to summarize the impact of EtOH on striatal function and provide a mechanistic explanation for alcohol-responsive movement disorders, suggesting potential drug repositioning based on different hypotheses.
Article
Chemistry, Multidisciplinary
Guanglong Ma, Nina Kostevsek, Ilaria Monaco, Amalia Ruiz, Bostjan Markelc, Calvin C. L. Cheung, Samo Hudoklin, Mateja E. Kreft, Hatem A. F. M. Hassan, Matthew Barker, Jamie Conyard, Christopher Hall, Stephen Meech, Andrew G. Mayes, Igor Sersa, Maja Cemazar, Katarina Markovic, Janez Scancar, Mauro Comes Franchini, Wafa T. Al-Jamal
Summary: This study investigates the effect of PD1 blockade in combination with photothermally-activated low temperature-sensitive magnetoliposomes (mLTSL) loaded with doxorubicin for cancer therapy. The results demonstrate the efficient drug delivery and imaging capabilities of mLTSL, as well as the potentiation of therapeutic efficacy when combined with anti-PD1 monoclonal antibody.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cell Biology
Marc Morissette, Melanie Bourque, Marie-Eve Tremblay, Therese Di Paolo
Summary: Inflammatory markers were found in the brains of Parkinson's disease patients. The study showed that MPEP reduced the development of L-Dopa-induced dyskinesias (LID) in MPTP-lesioned monkeys and decreased inflammatory markers in the brain. The results demonstrated increased inflammatory markers in the basal ganglia associated with LID and revealed the potential of MPEP in reducing LID and inflammatory response.
Review
Pharmacology & Pharmacy
Maleesha Ubhayarathna, Christopher J. Langmead, Natalie A. Diepenhorst, Gregory D. Stewart
Summary: Substance use disorder is a chronic condition with limited treatment options. The serotonin 2C receptor shows potential for the treatment of SUD, and research on psychedelics has also focused on this receptor. New studies provide a basis for further exploration.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Lise Guilhemsang, Amaia Gutierrez-Ceballos, Mario Antonazzo, Nicolas P. Mallet, Luisa Ugedo, Teresa Morera-Herreras
Summary: This study investigated the modulatory effects of 5-HT2A receptor stimulation on the basal ganglia circuitry, specifically targeting the mPF information processing through trans-striatal pathways. The results showed that the 5-HT2A agonist TCB-2 increased the firing rate and inhibitory response of medial SNr neurons, while the 5-HT2A receptor antagonist MDL11939 blocked these effects. Overall, these findings suggest a preferential modulatory action of 5-HT2A receptors on the dynamic regulation of basal ganglia circuitry.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biology
Jonathan S. Schor, Isabelle Gonzalez Montalvo, Perry W. E. Spratt, Rea J. Brakaj, Jasmine A. Stansil, Emily L. Twedell, Kevin J. Bender, Alexandra B. Nelson
Summary: This study investigated the therapeutic effects and underlying mechanisms of subthalamic nucleus deep brain stimulation (STN DBS) in Parkinson's disease mice. The results suggest that STN DBS exerts its therapeutic effects through disrupting movement-related activity in the subthalamic nucleus. These findings provide new insights for optimizing Parkinson's disease treatments and offer an approach for studying deep brain stimulation in other neuropsychiatric conditions.
Article
Cell Biology
Gwenaelle Laverne, Jonathan Pesce, Ana Reynders, Etienne Combrisson, Eduardo Gascon, Christophe Melon, Lydia Kerkerian-Le Goff, Nicolas Maurice, Corinne Beurrier
Summary: Striatal cholinergic interneurons (CINs) play an important regulatory role in cortico-striatal transmission and striatal-dependent motor-skill learning, which is dependent on the integrity of dopaminergic inputs.
Article
Multidisciplinary Sciences
Esther Vinner Harduf, Ayala Matzner, Katya Belelovsky, Izhar Bar-Gad
Summary: The study demonstrates a reduction in tic expression during sleep in an animal model of chronic tic disorders and investigates the underlying neural mechanism. The findings point towards a possible mechanism for the modulation of tic expression in patients with TS during sleep and potentially during other behavioral states.
Article
Multidisciplinary Sciences
Shinwoo Kang, Sa-Ik Hong, Seungwoo Kang, Minryung Song, Minsu Abel Yang, Hesham Essa, Matthew Baker, Jeyeon Lee, Robert A. Bruce, Sang Wan Lee, Doo-Sup Choi
Summary: A study found that astrocytic activity in the external globus pallidus (GPe) is attenuated during habitual learning compared to goal-directed learning. Increased expression of GABA transporter type 3 (GAT3) in astrocytes during habit learning inhibits the transition from habitual to goal-directed behavior.
Article
Multidisciplinary Sciences
Matthew Baker, Seungwoo Kang, Sa-Ik Hong, Minryung Song, Minsu Abel Yang, Lee Peyton, Hesham Essa, Sang Wan Lee, Doo-Sup Choi
Summary: The authors found that GPe arky neurons are involved in reward-seeking behaviors and primarily project to the dorsolateral striatum. Genetic ablation of this circuit shift behavior from goal-directed to habitual seeking.
NATURE COMMUNICATIONS
(2023)
Article
Critical Care Medicine
Gabriel Jakobsson, Praveen Papareddy, Henrik Andersson, Megan Mulholland, Ravi Bhongir, Irena Ljungcrantz, Daniel Engelbertsen, Harry Bjorkbacka, Jan Nilsson, Adrian Manea, Heiko Herwald, Marisol Ruiz-Meana, Antonio Rodriguez-Sinovas, Michelle Chew, Alexandru Schiopu
Summary: This study revealed the association between elevated plasma S100A8/A9 levels and left ventricle dysfunction in severe sepsis patients, and demonstrated the potential therapeutic effects of pharmacological blockade of S100A8/A9 in mitigating myocardial dysfunction.
Article
Biochemistry & Molecular Biology
Dora C. Tarlungeanu, Elena Deliu, Christoph P. Dotter, Majdi Kara, Philipp Christoph Janiesch, Mariafrancesca Scalise, Michele Galluccio, Mateja Tesulov, Emanuela Morelli, Fatma Mujgan Sonmez, Kaya Bilguvar, Ryuichi Ohgaki, Yoshikatsu Kanai, Anide Johansen, Seham Esharif, Tawfeg Ben-Omran, Meral Topcu, Avner Schlessinger, Cesare Indiveri, Kent E. Duncan, Ahmet Okay Caglayan, Murat Gunel, Joseph G. Gleeson, Gaia Novarino
Article
Neurosciences
Emanuela Morelli, Veronica Ghiglieri, Valentina Pendolino, Vincenza Bagetta, Annabella Pignataro, Anna Fejtova, Cinzia Costa, Martine Ammassari-Teule, Eckart D. Gundelfinger, Barbara Picconi, Paolo Calabresi
EXPERIMENTAL NEUROLOGY
(2014)
Article
Neurosciences
Valentina Pendolino, Vincenza Bagetta, Veronica Ghiglieri, Carmelo Sgobio, Emanuela Morelli, Silvia Poggini, Igor Branchi, Emanuele C. Latagliata, Tiziana Pascucci, Stefano Puglisi-Allegra, Paolo Calabresi, Barbara Picconi
EXPERIMENTAL NEUROLOGY
(2014)
Article
Behavioral Sciences
J. M. Muller, E. Morelli, M. Ansorge, J. A. Gingrich
GENES BRAIN AND BEHAVIOR
(2011)
Article
Neurosciences
Mark S. Ansorge, Emanuela Morelli, Jay A. Gingrich
JOURNAL OF NEUROSCIENCE
(2008)
Article
Neurosciences
Emanuela Morelli, Holly Moore, Tahilia J. Rebello, Neil Gray, Kelly Steele, Ennio Esposito, Jay A. Gingrich, Mark S. Ansorge
JOURNAL OF NEUROSCIENCE
(2011)
Article
Neurosciences
Tahilia J. Rebello, Qinghui Yu, Nathalie M. Goodfellow, Martha K. Caffrey Cagliostro, Anne Teissier, Emanuela Morelli, Elena Y. Demireva, Alexei Chemiakine, Gorazd B. Rosoklija, Andrew J. Dwork, Evelyn K. Lambe, Jay A. Gingrich, Mark S. Ansorge
JOURNAL OF NEUROSCIENCE
(2014)
Review
Physiology
John F. Cryan, Kenneth J. O'Riordan, Caitlin S. M. Cowan, Kiran V. Sandhu, Thomaz F. S. Bastiaanssen, Marcus Boehme, Martin G. Codagnone, Sofia Cussotto, Christine Fulling, Anna V. Golubeva, Katherine E. Guzzetta, Minal Jaggar, Caitriona M. Long-Smith, Joshua M. Lyte, Jason A. Martin, Alicia Molinero-Perez, Gerard Moloney, Emanuela Morelli, Enrique Morillas, Rory O'Connor, Joana S. Cruz-Pereira, Veronica L. Peterson, Kieran Rea, Nathaniel L. Ritz, Eoin Sherwin, Simon Spichak, Emily M. Teichman, Marcel van de Wouw, Ana Paula Ventura-Silva, Shauna E. Wallace-Fitzsimons, Niall Hyland, Gerard Clarke, Timothy G. Dinan
PHYSIOLOGICAL REVIEWS
(2019)
Article
Multidisciplinary Sciences
Noelia V. Weisstaub, Mingming Zhou, Alena Lira, Evelyn Lambe, Javier Gonzalez-Maeso, Jean-Pierre Hornung, Etienne Sibille, Mark Underwood, Shigeyoshi Itohara, William T. Dauer, Mark S. Ansorge, Emanuela Morelli, J. John Mann, Miklos Toth, George Aghajanian, Stuart C. Sealfon, Rene Hen, Jay A. Gingrich