Article
Radiology, Nuclear Medicine & Medical Imaging
Daniele Bertoglio, Jeroen Verhaeghe, Alan Miranda, Leonie Wyffels, Sigrid Stroobants, Ladislav Mrzljak, Vinod Khetarpal, Mette Skinbjerg, Longbin Liu, Celia Dominguez, Ignacio Munoz-Sanjuan, Jonathan Bard, Steven Staelens
Summary: The study demonstrated that the novel radioligand [C-11]CHDI-626 is suitable for mHTT PET imaging. Longitudinal quantification revealed genotype differences, with an increase in signal in HET mice associated with mHTT aggregate load progression.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Biochemistry & Molecular Biology
Yilong Cui, Hiroyuki Neyama, Di Hu, Tianliang Huang, Emi Hayashinaka, Yasuhiro Wada, Yasuyoshi Watanabe
Summary: In this study, several brain regions that are activated in response to mechanical allodynia in neuropathic pain rat models were successfully identified using FDG PET scanning. These regions include the medial prefrontal cortex, primary somatosensory cortex hindlimb region, and the centrolateral thalamic nucleus. Moreover, the brain activity in these regions was positively correlated with behavioral changes related to mechanical allodynia. These findings suggest that FDG PET imaging in neuropathic pain model rats can evaluate regional brain activity encoding the multidimensional aspects of pain, bridging the gap between preclinical and clinical investigations.
Article
Endocrinology & Metabolism
Giovanna Nordio, Rubaida Easmin, Alessio Giacomel, Ottavia Dipasquale, Daniel Martins, Steven Williams, Federico Turkheimer, Oliver Howes, Mattia Veronese, Sameer Jauhar, Maria Rogdaki, Robert McCutcheon, Stephen Kaar, Luke Vano, Grazia Rutigliano, Ilinca Angelescu, Faith Borgan, Enrico D'Ambrosio, Tarik Dahoun, Euitae Kim, Seoyoung Kim, Micheal Bloomfield, Alice Egerton, Arsime Demjaha, Ilaria Bonoldi, Chiara Nosarti, James Maccabe, Philip McGuire, Julian Matthews, Peter S. Talbot
Summary: In this study, a fully automated analytical framework for FDOPA PET neuroimaging data was evaluated. The framework showed good reproducibility and sensitivity to demographic and experimental variables. It represents an effective resource for standardized and robust quantification of dopamine synthesis capacity using FDOPA PET data.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Amanda Marie Vanslette, Pernille Baumann Toft, Mari Lilith Lund, Thomas Moritz, Tulika Arora
Summary: This study found that a high fat diet can reduce the expression and secretion of gut hormones, as well as decrease GLP-1 levels. Supplementation of sodium propionate did not improve this condition, while chemical induction of serotonin receptor 4 can increase GLP-1 levels and improve glucose tolerance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Clinical Neurology
Sotiria Maria Iliopoulou, Stergios Tsartsalis, Stefan Kaiser, Philippe Millet, Benjamin B. Tournier
Summary: Schizophrenia is a complex disease with pathophysiology that involves interactions between dopamine and neuroinflammation. Dopamine may inhibit neuroinflammation in activated microglia, while proinflammatory molecules from microglia may decrease dopaminergic transmission. Further studies on the association between microglial activation and dopamine system function are needed to better understand the complex nature of schizophrenia.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Psychiatry
Angharad N. de Cates, Marieke A. G. Martens, Lucy C. Wright, Cassandra D. Gould van Praag, Liliana P. Capitao, Daisy Gibson, Philip J. Cowen, Catherine J. Harmer, Susannah E. Murphy
Summary: Depression is a prevalent illness with global impact. Current antidepressants are ineffective for a significant portion of patients, and 5-HT4 receptor agonists show potential in animal models and cognitive deficits. This study found that the 5-HT4 partial agonist prucalopride improved accuracy in identifying emotional faces in healthy participants, and inhibited activation in regions corresponding to the default mode network. However, there was no evidence of a positive bias in the neural processing of emotional faces with prucalopride treatment.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Oskar Hansson, Nicholas Cullen, Henrik Zetterberg, Kaj Blennow, Niklas Mattsson-Carlgren
Summary: The study found that high plasma tau levels were associated with hypometabolism and cortical atrophy, and these associations were observed only in Aβ-positive participants. Plasma phosphorylated tau may help identify and track processes linked to neurodegeneration in Alzheimer's disease.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Parijat Sarkar, Kaleeckal G. Harikumar, Satinder S. Rawat, Sanjib Das, Tushar K. Chakraborty, Amitabha Chattopadhyay
Summary: Serotonin is a crucial neurotransmitter that regulates various functions by binding to different serotonin receptors. Novel fluorescent analogs of serotonin have been synthesized and characterized, showing high environmental sensitivity and specific binding to serotonin receptors, providing a new fluorescent approach for studying the molecular environment of serotonin receptors.
Review
Biochemistry & Molecular Biology
Syed M. S. Abidi, Chandni Sharma, Shiwani Randhawa, Ashish K. Shukla, Amitabha Acharya
Summary: Early detection of neurodegenerative diseases is crucial, and nanotechnology can enhance neurofunctional imaging and biomarker detection for improved specificity and sensitivity in diagnosis. The use of nanomaterials can also overcome the blood-brain barrier for drug delivery. The application of nanotechnology is of great significance in the research of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Agriculture, Dairy & Animal Science
Manuel Mengoli, Jessica L. Oliva, Tiago Mendonca, Camille Chabaud, Sana Arroub, Celine Lafont-Lecuelle, Alessandro Cozzi, Patrick Pageat, Cecile Bienboire-Frosini
Summary: Assistance dogs and pet dogs were compared in this study using blood neuromodulator indicators to find potential biomarkers for improving assistance dog breeding, selection, training, and welfare. Age and activity were found to significantly influence oxytocin concentrations in these dogs, with potential effects on prolactin and serotonin levels as well. The study suggests that blood prolactin, serotonin, and oxytocin could serve as biomarkers for assessing workload and stress responses in assistance dogs.
Article
Pharmacology & Pharmacy
Ahmed Haider, Xiaoyun Deng, Olivia Mastromihalis, Stefanie K. Pfister, Troels E. Jeppesen, Zhiwei Xiao, Vi Pham, Shaofa Sun, Jian Rong, Chunyu Zhao, Jiahui Chen, Yinlong Li, Theresa R. Connors, April T. Davenport, James B. Daunais, Vahid Hosseini, Wenqing Ran, Arthur Christopoulos, Lu Wang, Celine Valant, Steven H. Liang
Summary: This study aimed to develop a suitable M4 PET ligand for the non-invasive visualization of M4 in the brain. The compound 12 was identified as a subtype-selective positive allosteric modulator (PAM) and its radiofluorinated analogue showed moderate specificity in rodent brain sections. However, in non-human primates and humans, the presence of carbachol did not improve the specificity and selectivity of the radioligand.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Psychiatry
Yange Wei, Ran Zhang, Yang Wang, Fay Y. Womer, Shuai Dong, Junjie Zheng, Xizhe Zhang, Fei Wang
Summary: This study identified increased regional homogeneity (ReHo) in the dorsolateral prefrontal cortex (DLPFC) of patients with depression following cognitive behavioural therapy (CBT). Pre-CBT ReHo in the left DLPFC was found to predict post-CBT Hamilton Depression Rating Scale (HAMD) scores. Left DLPFC ReHo was identified as a neuroimaging biomarker for the therapeutic effects of CBT in depression.
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Pia S. Zeiner, Leonhard Mann, Katharina Filipski, Tatjana Starzetz, Marie-Therese Forster, Michael W. Ronellenfitsch, Joachim P. Steinbach, Michel Mittelbronn, Marlies Wagner, Patrick N. Harter
Summary: This study retrospectively analyzed 15 patients with PML, finding that patients with MRI-defined iPML had a higher intensity of inflammation, while cPML patients also demonstrated inflammatory tissue alterations. Infiltration of CD163-positive microglia and macrophages correlated with PML lesion size.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Nitika Goenka, Shamik Tiwari
Summary: Alzheimer's disease is a neurological disorder that leads to memory loss and death, with no known cure. This study used Florbetapir PET scans as a neuroimaging biomarker and found that a 3D patch-based feature extraction method was the most accurate in Alzheimer's categorization. Three different slicing algorithms were tested, and it was discovered that the uniform slice and interpolation selection methods outperformed the subset slice method. The Ensemble Net model achieved high accuracy in classifying Alzheimer's disease.
Article
Clinical Neurology
Alejandro D. Meruelo, Ty Brumback, Bonnie J. Nagel, Fiona C. Baker, Sandra A. Brown, Susan F. Tapert
Summary: Thinner cortices in the frontal and temporal regions during adolescence may be linked to increased vulnerability for future depression. Future research with larger sample sizes will be needed to confirm these results.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Moshgan Amiri, Patrick M. Fisher, Federico Raimondo, Annette Sidaros, Melita Cacic Hribljan, Marwan H. Othman, Ivan Zibrandtsen, Simon A. Albrechtsen, Ove Bergdal, Adam Espe Hansen, Christian Hassager, Joan Lilja S. Hojgaard, Elisabeth Waldemar Jakobsen, Helene Ravnholt Jensen, Jacob Moller, Vardan Nersesjan, Miki Nikolic, Markus Harboe Olsen, Sigurdur Thor Sigurdsson, Jacobo D. Sitt, Christine Solling, Karen Lise Welling, Lisette M. Willumsen, John Hauerberg, Vibeke Andree Larsen, Martin Ejler Fabricius, Gitte Moos Knudsen, Jesper Kjaergaard, Kirsten Moller, Daniel Kondziella
Summary: This study aimed to assess the accuracy of fMRI and EEG in identifying residual consciousness in patients with acute disorders of consciousness (DoC) in the intensive care unit (ICU). The study found that a combination of fMRI and EEG features can predict the level of consciousness in patients, which is important for clinical decision-making.
Article
Neurosciences
Lars Nyberg, Micael Andersson, Anders Lundquist, William F. C. Baare, David Bartres-Faz, Lars Bertram, Carl-Johan Boraxbekk, Andreas M. Brandmaier, Naiara Demnitz, Christian A. Drevon, Sandra Duezel, Klaus P. Ebmeier, Paolo Ghisletta, Richard Henson, Daria E. A. Jensen, Rogier A. Kievit, Ethan Knights, Simone Kuhn, Ulman Lindenberger, Anna Plachti, Sara Pudas, James M. Roe, Kathrine Skak Madsen, Cristina Sole-Padulles, Yasmine Sommerer, Sana Suri, Eniko Zsoldos, Anders M. Fjell, Kristine B. Walhovd
Summary: We found heterogeneity in regional-atrophy patterns through latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. Our findings suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.
Article
Psychiatry
Kristian Hoj Reveles Jensen, Vibeke H. Dam, Melanie Ganz, Patrick MacDonald Fisher, Cheng-Teng Ip, Anjali Sankar, Maja Rou Marstrand-Joergensen, Brice Ozenne, Merete Osler, Brenda W. J. H. Penninx, Lars H. Pinborg, Vibe Gedso Frokjaer, Gitte Moos Knudsen, Martin Balslev Jorgensen
Summary: The study aims to understand the heterogeneity of major depressive disorder (MDD) and markers of treatment response. It will recruit 800 MDD patients and collect clinical, cognitive, psychometric, and biological data. Using machine learning and statistical models, the study will investigate the associations between individual characteristics, treatment choices, and clinical outcomes.
Article
Clinical Neurology
Tine B. Gehrt, Julian Macoveanu, Christopher J. Bailey, Patrick M. Fisher, Karen Johanne Pallesen, Lisbeth Frostholm
Summary: Severe health anxiety is characterized by persistent preoccupation with one's health, and biases in processing health-related stimuli are consistently associated with symptoms. However, the neural correlates of these behavioral abnormalities are poorly understood.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Clinical
Julian Macoveanu, Jeff Zarp Petersen, Patrick M. Fisher, Lars Vedel Kessing, Gitte Moos Knudsen, Kamilla Woznica Miskowiak
Summary: This study used fMRI to investigate cognitive deficits in patients with bipolar disorder and unipolar disorder. The results showed that these patients had hypo-activity in certain brain regions associated with cognitive control, as well as hyper-activity in other brain regions associated with default mode network.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Anjali Sankar, Brice Ozenne, Vibeke H. Dam, Claus Svarer, Martin B. Jorgensen, Kamilla W. Miskowiak, Vibe G. Frokjaer, Gitte M. Knudsen, Patrick M. Fisher
Summary: This study is the first to examine the association between 5-HT4R binding and neural responses to emotions in patients with MDD and healthy controls. The findings showed a positive correlation between 5-HT4R binding and corticolimbic responses to emotional faces across participants. However, this association did not differ between groups.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Anjali Sankar, Simon C. Ziersen, Brice Ozenne, Emily E. Beaman, Vibeke H. Dam, Patrick M. Fisher, Gitte M. Knudsen, Lars V. Kessing, Vibe Frokjaer, Kamilla W. Miskowiak
Summary: This study found that severe verbal memory impairment is associated with an increased risk of future psychiatric hospitalization in individuals with affective disorders, while it is unrelated to the worsening of socio-demographic conditions.
Article
Endocrinology & Metabolism
Daniel Radbro Burmester, Martin Korsbak Madsen, Attila Szabo, Sagar Sanjay Aripaka, Dea Siggaard Stenbaek, Vibe G. Frokjaer, Betina Elfving, Jens D. Mikkelsen, Gitte Moos Knudsen, Patrick MacDonald Fisher
Summary: This study investigated the effect of a single dose of psilocybin on biomarkers of inflammation in healthy individuals. The results showed that psilocybin did not significantly reduce the concentrations of inflammation biomarkers. The study suggested that future research should consider additional markers of inflammation, including neuroinflammation markers, and evaluate the potential anti-inflammatory effects of psilocybin therapy in clinical populations.
COMPREHENSIVE PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Julian Macoveanu, Johanna Mariegaard, Jeff Zarp Petersen, Patrick M. Fisher, Maj Vinberg, Martin Balslev Jorgensen, Gitte Moos Knudsen, Lars Vedel Kessing, Kamilla Woznica Miskowiak
Summary: This study found that patients with affective disorders in remission exhibited cognitive and functional impairments, with lower activity in the dorsal prefrontal cortex (dPFC) during task performance. The activity in the right dlPFC was associated with overall functioning and antipsychotic drug use. These findings have implications for the development of cognitive interventions targeting both cognition and real-world functioning.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychiatry
Line Korsgaard Johnsen, Kit Melissa Larsen, Soren Asp Fuglsang, Anna Hester Ver Loren van Themaat, William Frans Christiaan Baare, Kathrine Skak Madsen, Kristoffer Hougaard Madsen, Nicoline Hemager, Anna Krogh Andreassen, Lotte Veddum, Aja Neergaard Greve, Ayna Baladi Nejad, Birgitte Klee Burton, Maja Gregersen, Heike Eichele, Torben E. Lund, Vibeke Bliksted, Anne Amalie Elgaard Thorup, Ole Mors, Kerstin Jessica Plessen, Merete Nordentoft, Hartwig Roman Siebner
Summary: This study examines children with familial high-risk of SZ or BP and finds that they may have impaired executive control and aberrant brain activation compared to population-based control children.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Annika Laebo Rasmussen, Soren Vinther Larsen, Brice Ozenne, Kristin Kohler-Forsberg, Dea Siggaard Stenbaek, Martin Balslev Jorgensen, Annamaria Giraldi, Vibe G. Frokjaer
Summary: Sexual dysfunction is common in depression, especially in women. Lower brain levels of the 5-HT4 receptor in patients with depression may be related to reduced sexual desire. This study aims to investigate the neurobiology of sexual dysfunction in untreated patients with depression.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychology, Biological
Anders M. Fjell, Oystein Sorensen, Yunpeng Wang, Inge K. Amlien, William F. C. Baare, David Bartres-Faz, Lars Bertram, Carl-Johan Boraxbekk, Andreas M. Brandmaier, Ilja Demuth, Christian A. Drevon, Klaus P. Ebmeier, Paolo Ghisletta, Rogier Kievit, Simone Kuehn, Kathrine Skak Madsen, Athanasia M. Mowinckel, Lars Nyberg, Claire E. Sexton, Cristina Sole-Padulles, Didac Vidal-Pineiro, Gerd Wagner, Leiv Otto Watne, Kristine B. Walhovd
Summary: Short sleep duration is not directly associated with brain health, and normal brains promote adequate sleep.
NATURE HUMAN BEHAVIOUR
(2023)
Editorial Material
Neurosciences
Vibe G. Frokjaer
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Psychiatry
Trine Munk-Olsen, Arianna Di Florio, Kathrine B. Madsen, Clara Albinana, Merete L. Maegbaek, Veerle Bergink, Vibe G. Frokjaer, Esben Agerbo, Bjarni J. Vilhjalmsson, Thomas Werge, Merete Nordentoft, David M. Hougaard, Anders D. Borglum, Ole Mors, Preben Bo Mortensen, Xiaoqin Liu
Summary: Using a nested case-control study, we found that polygenic risk scores differ between postpartum depression (PPD) cases and depression with onset outside the postpartum period (MDD) cases, suggesting a potential genetic distinction. However, after accounting for selection-related reproductive behavior, there was no clear evidence of a distinct genetic makeup in women with depression occurring during or outside the postpartum period.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Juliane Conradi, Jonas E. Svensson, Soren V. Larsen, Vibe G. Frokjaer
Summary: This study did not confirm a positive association between the cortisol awakening response (CAR) and prefrontal 5-HTT BPND in an independent dataset, and there were no apparent sex differences in the association. The data do not exclude the involvement of the serotonin transporter system in regulating stress responses in at-risk or manifest depressed states.
