Imaging glutamate in schizophrenia: review of findings and implications for drug discovery
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Imaging glutamate in schizophrenia: review of findings and implications for drug discovery
Authors
Keywords
-
Journal
MOLECULAR PSYCHIATRY
Volume 19, Issue 1, Pages 20-29
Publisher
Springer Nature
Online
2013-10-29
DOI
10.1038/mp.2013.136
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action
- (2014) Olivia Dean et al. JOURNAL OF PSYCHIATRY & NEUROSCIENCE
- 18F-FPEB, a PET Radiopharmaceutical for Quantifying Metabotropic Glutamate 5 Receptors: A First-in-Human Study of Radiochemical Safety, Biokinetics, and Radiation Dosimetry
- (2013) D. F. Wong et al. JOURNAL OF NUCLEAR MEDICINE
- Glutamate Levels in the Associative Striatum Before and After 4 Weeks of Antipsychotic Treatment in First-Episode Psychosis
- (2013) Camilo de la Fuente-Sandoval et al. JAMA Psychiatry
- Glutamatergic changes in the cerebral white matter associated with schizophrenic exacerbation
- (2012) M. Ota et al. ACTA PSYCHIATRICA SCANDINAVICA
- Elevated Prefrontal Cortex γ-Aminobutyric Acid and Glutamate-Glutamine Levels in Schizophrenia Measured In Vivo With Proton Magnetic Resonance Spectroscopy
- (2012) Xiangling Mao ARCHIVES OF GENERAL PSYCHIATRY
- Increased Metabotropic Glutamate Receptor Subtype 5 Availability in Human Brain After One Night Without Sleep
- (2012) Katharina Hefti et al. BIOLOGICAL PSYCHIATRY
- Synthesis and evaluation of [18F]Fluorobutyl ethacrynic amide: A potential PET tracer for studying glutathione transferase
- (2012) Ho-Lien Huang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Striatal glutamate and the conversion to psychosis: a prospective 1H-MRS imaging study
- (2012) Camilo de la Fuente-Sandoval et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Kinetic Analysis of the Metabotropic Glutamate Subtype 5 Tracer [18F]FPEB in Bolus and Bolus-Plus-Constant-Infusion Studies in Humans
- (2012) Jenna M Sullivan et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents
- (2012) S Miyamoto et al. MOLECULAR PSYCHIATRY
- Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology
- (2012) J M Stone et al. MOLECULAR PSYCHIATRY
- Regional Decoupling of N-acetyl-aspartate and Glutamate in Schizophrenia
- (2012) Nina V Kraguljac et al. NEUROPSYCHOPHARMACOLOGY
- Glycine Transporter Type 1 Occupancy by Bitopertin: a Positron Emission Tomography Study in Healthy Volunteers
- (2012) Meret Martin-Facklam et al. NEUROPSYCHOPHARMACOLOGY
- Anterior Cingulate Glutamate Levels Related to Clinical Status Following Treatment in First-Episode Schizophrenia
- (2012) Alice Egerton et al. NEUROPSYCHOPHARMACOLOGY
- Multimodal analysis of the hippocampus in schizophrenia using proton magnetic resonance spectroscopy and functional magnetic resonance imaging
- (2012) Nathan L. Hutcheson et al. SCHIZOPHRENIA RESEARCH
- Test-retest stability of cerebral mGluR5 quantification using [11C]ABP688 and positron emission tomography in rats
- (2012) David Elmenhorst et al. SYNAPSE
- Reduced Metabotropic Glutamate Receptor 5 Density in Major Depression Determined by [11C]ABP688 PET and Postmortem Study
- (2011) Alexandra Deschwanden et al. AMERICAN JOURNAL OF PSYCHIATRY
- Thalamic Glutamate Levels as a Predictor of Cortical Response During Executive Functioning in Subjects at High Risk for Psychosis
- (2011) P. Fusar-Poli ARCHIVES OF GENERAL PSYCHIATRY
- Imaging Changes in Glutamate Transmission In Vivo with the Metabotropic Glutamate Receptor 5 Tracer [11C] ABP688 and N-Acetylcysteine Challenge
- (2011) Nobumi Miyake et al. BIOLOGICAL PSYCHIATRY
- N-Acetylcysteine Normalizes Neurochemical Changes in the Glutathione-Deficient Schizophrenia Mouse Model During Development
- (2011) Joao Miguel das Neves Duarte et al. BIOLOGICAL PSYCHIATRY
- Grey matter and social functioning correlates of glutamatergic metabolite loss in schizophrenia
- (2011) Naoko Aoyama et al. BRITISH JOURNAL OF PSYCHIATRY
- Meta-Analysis of the Efficacy of Adjunctive NMDA Receptor Modulators in Chronic Schizophrenia
- (2011) Surendra P. Singh et al. CNS DRUGS
- In vivo positron emission tomography imaging with [11C]ABP688: binding variability and specificity for the metabotropic glutamate receptor subtype 5 in baboons
- (2011) Christine DeLorenzo et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- in vivo Variation in Metabotropic Glutamate Receptor Subtype 5 Binding Using Positron Emission Tomography and [11C]ABP688
- (2011) Christine DeLorenzo et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- A Multicenter, Inpatient, Phase 2, Double-Blind, Placebo-Controlled Dose-Ranging Study of LY2140023 Monohydrate in Patients With DSM-IV Schizophrenia
- (2011) Bruce J. Kinon et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Increased prefrontal cortical D1 receptors in drug naïve patients with schizophrenia: a PET study with [11C]NNC112
- (2011) Anissa Abi-Dargham et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Lack of effect of ketamine on cortical glutamate and glutamine in healthy volunteers: a proton magnetic resonance spectroscopy study
- (2011) Matthew J Taylor et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Higher Levels of Glutamate in the Associative-Striatum of Subjects with Prodromal Symptoms of Schizophrenia and Patients with First-Episode Psychosis
- (2011) Camilo de la Fuente-Sandoval et al. NEUROPSYCHOPHARMACOLOGY
- Proton Magnetic Resonance Spectroscopy Study of Brain Metabolite Changes after Antipsychotic Treatment
- (2011) A. Szulc et al. PHARMACOPSYCHIATRY
- Proton Magnetic Resonance Spectroscopy in 22q11 Deletion Syndrome
- (2011) Fabiana da Silva Alves et al. PLoS One
- Proton magnetic resonance spectroscopy and thought disorder in childhood schizophrenia
- (2011) Ronald R. Seese et al. SCHIZOPHRENIA RESEARCH
- Translating Glutamate: From Pathophysiology to Treatment
- (2011) D. C. Javitt et al. Science Translational Medicine
- Translational characterization of [11C]GSK931145, a PET ligand for the glycine transporter type 1
- (2011) Roger N. Gunn et al. SYNAPSE
- Assessments of Function and Biochemistry of the Anterior Cingulate Cortex in Schizophrenia
- (2010) Meredith A. Reid et al. BIOLOGICAL PSYCHIATRY
- Glutamate as a Marker of Cognitive Function in Schizophrenia: A Proton Spectroscopic Imaging Study at 4 Tesla
- (2010) Juan R. Bustillo et al. BIOLOGICAL PSYCHIATRY
- Altered Medial Temporal Activation Related to Local Glutamate Levels in Subjects with Prodromal Signs of Psychosis
- (2010) Isabel Valli et al. BIOLOGICAL PSYCHIATRY
- N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: The final common pathway on the road to schizophrenia?
- (2010) Joshua T. Kantrowitz et al. BRAIN RESEARCH BULLETIN
- Potential Psychiatric Applications of Metabotropic Glutamate Receptor Agonists and Antagonists
- (2010) John H. Krystal et al. CNS DRUGS
- Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a Promising Novel Medicine To Treat Schizophrenia
- (2010) Emmanuel Pinard et al. JOURNAL OF MEDICINAL CHEMISTRY
- Biodistribution and Radiation Dosimetry of the Glycine Transporter-1 Ligand 11C-GSK931145 Determined from Primate and Human Whole-Body PET
- (2010) Santiago Bullich et al. MOLECULAR IMAGING AND BIOLOGY
- The synthesis and preclinical evaluation in rhesus monkey of [18F]MK-6577 and [11C]CMPyPB glycine transporter 1 positron emission tomography radiotracers
- (2010) Terence G. Hamill et al. SYNAPSE
- Glutamate Dysfunction in People with Prodromal Symptoms of Psychosis: Relationship to Gray Matter Volume
- (2009) James M. Stone et al. BIOLOGICAL PSYCHIATRY
- 1H-MRS at 4 Tesla in minimally treated early schizophrenia
- (2009) J R Bustillo et al. MOLECULAR PSYCHIATRY
- Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus
- (2009) Jason M. Uslaner et al. NEUROPHARMACOLOGY
- mGluR5 Positive Allosteric Modulators Facilitate both Hippocampal LTP and LTD and Enhance Spatial Learning
- (2009) Jennifer E Ayala et al. NEUROPSYCHOPHARMACOLOGY
- Proton magnetic resonance spectroscopy in subjects with high genetic risk of schizophrenia: Investigation of anterior cingulate, dorsolateral prefrontal cortex and thalamus
- (2009) So Young Yoo et al. SCHIZOPHRENIA RESEARCH
- Striatal metabolic alterations in non-psychotic adolescent offspring at risk for schizophrenia: A 1H spectroscopy study
- (2009) Matcheri S. Keshavan et al. SCHIZOPHRENIA RESEARCH
- Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice
- (2008) Olivia Dean et al. BEHAVIOURAL BRAIN RESEARCH
- Abnormal Glutamatergic Neurotransmission and Neuronal-Glial Interactions in Acute Mania
- (2008) Dost Öngür et al. BIOLOGICAL PSYCHIATRY
- N-Acetyl Cysteine as a Glutathione Precursor for Schizophrenia—A Double-Blind, Randomized, Placebo-Controlled Trial
- (2008) Michael Berk et al. BIOLOGICAL PSYCHIATRY
- ADX47273 [S-(4-Fluoro-phenyl)- -methanone]: A Novel Metabotropic Glutamate Receptor 5-Selective Positive Allosteric Modulator with Preclinical Antipsychotic-Like and Procognitive Activities
- (2008) F. Liu et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Medial temporal lobe glutathione concentration in first episode psychosis: A 1H-MRS investigation
- (2008) Stephen J. Wood et al. NEUROBIOLOGY OF DISEASE
- White Matter Alterations in Deficit Schizophrenia
- (2008) Laura M Rowland et al. NEUROPSYCHOPHARMACOLOGY
- Negative Correlation between Brain Glutathione Level and Negative Symptoms in Schizophrenia: A 3T 1H-MRS Study
- (2008) Daisuke Matsuzawa et al. PLoS One
- Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy—a [123I]CNS-1261 SPET study
- (2008) James M. Stone et al. PSYCHOPHARMACOLOGY
- Learning potential on the WCST in schizophrenia is related to the neuronal integrity of the anterior cingulate cortex as measured by proton magnetic resonance spectroscopy
- (2008) P OHRMANN et al. SCHIZOPHRENIA RESEARCH
- Metabolite changes and gender differences in schizophrenia using 3-Tesla proton magnetic resonance spectroscopy (1H-MRS)
- (2008) Shin'Ya Tayoshi et al. SCHIZOPHRENIA RESEARCH
- Frontolimbic glutamate alterations in first episode schizophrenia: Evidence from a magnetic resonance spectroscopy study
- (2008) Hans M. Olbrich et al. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
- Neurochemical and structural correlates of executive dysfunction in schizophrenia
- (2007) Nicolas Rüsch et al. SCHIZOPHRENIA RESEARCH
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started