Journal
MOLECULAR PSYCHIATRY
Volume 16, Issue 3, Pages 282-285Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2009.126
Keywords
serotonin; 5-HT1A receptor; spirituality; positron emission tomography; major depressive disorder
Funding
- Signe and Ane Gyllenberg Foundation
- Social Insurance Institution of Finland
- Turku University Central Hospital [P3848]
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An earlier study (Borg et al., Am J Psychiatry 2003) found an inverse correlation between [carbonyl-C-11]WAY-100635 ligand binding to 5-HT1A receptors and scores for self-transcendence, but no other of the six dimensions of the Temperament and Character Inventory, in a group of healthy males. The aim of this study was to investigate if the finding of an inverse correlation between spirituality and 5-HT1A could be seen in patients suffering from major depressive disorder or replicated among healthy volunteers. A total of 23 patients with major depressive disorder and 20 healthy volunteers were examined with PET using [carbonyl-C-11]-WAY-100635 as the radioligand. The personality traits were measured using the Finnish version of the Temperament and Character Inventory and correlated with ligand binding (BP). No significant correlations were found between the different Temperament and Character Inventory subscales and BP in any of the studied brain regions (amygdala, anterior cingulate cortex, dorsal raphe nuclei, dorsolateral prefrontal cortex, angular gyrus, inferior, middle, and superior temporal gyri, medial prefrontal cortex orbitofrontal cortex, hippocampus, insular cortex, subgenual anterior cingulate cortex, supramarginal gyrus, ventrolateral prefrontal cortex, and posterior cingulate cortex). These results do not support the idea that the serotonin system forms the biological basis of spiritual experiences among patients suffering from major depressive disorder or among healthy volunteers. Molecular Psychiatry (2011) 16, 282-285; doi:10.1038/mp.2009.126; published online 24 November 2009
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