Review
Pediatrics
Florence A. Aeschlimann, Rae S. M. Yeung, Ronald M. Laxer
Summary: Takayasu Arteritis (TAK) is a rare inflammatory disease affecting the large blood vessels, causing severe manifestations in both systemic and local tissues. Despite newer understanding of its pathogenesis, there is still a lack of long-term data in children and the prognosis remains uncertain, with a high disease burden.
FRONTIERS IN PEDIATRICS
(2022)
Review
Cell Biology
Anthony Holland, Neil A. Bradbury
Summary: Cell sex is important in biomedical research, but the sex of cells derived from organs other than reproductive tissue is often overlooked. However, accumulating data show that genes expressed off sex chromosomes have a broad impact on various cells. Moreover, AJP-Cell Physiology requires clear indication of the source of all cells used when submitting an article. Nearly a decade later, it is important to evaluate if improvements have been made in the description of cells and cell lines used in publications submitted to AJP-Cell Physiology.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Psychology, Clinical
Anne-Sophie D. Enthoven, Shiral S. Gangadin, Lieuwe de Haan, Wim Veling, Erik F. J. de Vries, Janine Doorduin, Marieke J. H. Begemann, Iris E. C. Sommer
Summary: Childhood trauma may impact the severity of depressive and negative symptoms in patients with schizophrenia spectrum disorders, with differences between sexes. Depressive symptoms in men were associated with total trauma scores and emotional abuse, while in women they were associated with sexual abuse. Negative symptoms in men were linked to total trauma scores and emotional neglect, while in women there was no clear link potentially due to statistical power limitations.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Georgia Pitsava, Constantine A. Stratakis
Summary: Pediatric adrenocortical hyperplasias are rare conditions characterized by Cushing syndrome and genetic defects affecting the adrenal cortex. Most cases are caused by defects in the cyclic AMP/protein kinase A (cAMP/PKA) pathway, while a few cases have unidentified genetic defects. Congenital adrenal hyperplasia, mainly due to steroidogenic enzyme deficiencies, is another cause of adrenal hyperplasia in childhood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pediatrics
Vitor Cavalcanti Trindade, Magda Carneiro-Sampaio, Eloisa Bonfa, Clovis Artur Silva
Summary: Childhood-onset systemic lupus erythematosus (cSLE) is a complex autoimmune condition characterized by unpredictable flare and high morbidity and mortality rates. Treatment mainly involves antimalarials and glucocorticoids, with newer options such as biologic agents showing promise for future use in pediatric patients. Additionally, management practices for cSLE patients include regular evaluations, vaccinations, physical activity, and addressing mental health issues.
Review
Psychiatry
Olga Stepien-Wyrobiec, Marta Nowak, Grzegorz Wyrobiec, Emilia Morawiec, Magdalena Wierzbik-Stronska, Rafal Staszkiewicz, Beniamin Oskar Grabarek
Summary: Schizophrenia is a chronic and highly individualized disease characterized by a variety of symptoms that can occur with different severity levels. The incidence of the disease increases with age, especially in middle-aged and elderly patients. Clinical diagnosis and treatment are crucial for the involvement of patients' families and caregivers.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Alison C. Leslie, Michael O'Sullivan
Summary: Childhood-onset schizophrenia is a rare and severe form of schizophrenia that shares phenotypic features and genetic etiology with Autism spectrum disorder. There is increasing research on the co-occurrence of psychomotor syndromes like catatonia with neurodevelopmental disorders like ASD or psychiatric disorders like schizophrenia. The 'Iron Triangle' theory suggests a single underlying pathology resulting in a unique mixed form of catatonia, autism, and psychosis. This case highlights the overlapping diagnostic features of these disorders and the need for further study.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Multidisciplinary Sciences
German Lagunas-Robles, Jessica Purcell, Alan Brelsford
Summary: The discovery of a supergene determining split sex ratio in at least two ant species has opened up new avenues for research into the evolutionary drivers of this phenomenon.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Psychiatry
Mariachiara Buonocore, Marta Bosia, Francesca Martini, Margherita Bechi, Marco Spangaro, Giulia Agostoni, Olympia Diddi, Federica Cocchi, Federica Cuoco, Roberto Cavallaro
Summary: Sex and age of onset are crucial factors influencing cognition in schizophrenia. Females have higher age and age of onset, while males perform better in executive functions. Late-onset patients have better verbal memory performance, while early-onset patients have lower IQ. There is an interaction effect between sex and age at onset, with early-onset being associated with worse global cognition only in male patients.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Public, Environmental & Occupational Health
Dagrun Slettebo Daltveit, Kari Klungsoyr, Anders Engeland, Anders Ekbom, Mika Gissler, Ingrid Glimelius, Tom Grotmol, Laura Madanat-Harjuoja, Anne Gulbech Ording, Henrik Toft Sorensen, Rebecca Troisi, Tone Bjorge
Summary: This study found an association between childhood cancer and birth defects, with a stronger association observed among females. However, birth defects did not fully explain the differences in childhood cancer risk by sex, suggesting the involvement of other biological pathways.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Health Care Sciences & Services
Elizaveta S. Ershova, Natalia N. Veiko, Svetlana G. Nikitina, Elena E. Balakireva, Andrey Martynov, Julia M. Chudakova, Galina Shmarina, Svetlana E. Kostyuk, Nataliya A. Salimova, Roman V. Veiko, Lev N. Porokhovnik, Aliy Yu Asanov, Vera L. Izhevskaia, Sergey Kutsev, Nataliya Simashkova, Svetlana Kostyuk
Summary: This study compared the content of ribosomal repeats in the leucocyte DNA of children with schizophrenia, children with ASD, and healthy age-matched controls. The results showed that the DNA of children with schizophrenia had significantly higher copy numbers of ribosomal repeats than those with ASD and the healthy controls.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Ivonne Loeffler, Nadja Ziller
Summary: Differences between the sexes exist in many diseases, but it is not as clear in diabetic kidney disease (DKD) due to various factors such as duration of diabetes, glycemic control, and other risk factors. Sex-specific factors like puberty or menopause also play a role in microvascular complications for both males and females. This review aims to summarize the current knowledge on sex-related aspects in the development, progression, and treatment strategies of DKD, including findings from preclinical research.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychiatry
Leilei Wang, Wanjun Zeng, Yi Yin, Yanfang Zhou, Junchao Huang, Ping Zhang, Song Chen, Hongzhen Fan, Xingguang Luo, Shuping Tan, Zhiren Wang, Chiang-Shan R. Li, Baopeng Tian, Li Tian, Chuanlian Ma, Yanli Li, Yunlong Tan
Summary: The study investigates the relationship between sensory gating deficits, childhood trauma, and schizophrenia onset. It is found that patients with first-episode schizophrenia have more severe childhood trauma experiences and sensory gating deficits. Sensory gating deficits might mediate the effects of childhood trauma on the onset of schizophrenia.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Matthew A. Conte, Frances E. Clark, Reade B. Roberts, Luohao Xu, Wenjing Tao, Qi Zhou, Deshou Wang, Thomas D. Kocher
Summary: This study investigates the evolution of a giant sex chromosome in cichlid fish, finding that it consists of three distinct regions and contains unprecedented amounts of endogenous retroviral elements, immunoglobulin genes, and long non-coding RNAs. Comparative analysis across 69 teleost genomes supports the hypothesis that the giant sex chromosome originated from the fusion of a B chromosome.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth J. Snyder, Asha Sarma, Alexandra J. Borst, Aylin Tekes
Summary: Lymphatic anomalies encompass a range of disorders, from common localized lymphatic malformations to rare complex lymphatic anomalies. Imaging diagnosis of cystic lymphatic malformations is relatively straightforward, but diagnosing complex lymphatic anomalies can be more challenging. Radiologists play a crucial role in the diagnosis and management of complex lymphatic anomalies, and being familiar with the spectrum of entities and their typical imaging findings is important.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Genetics & Heredity
Ulrike Hueffmeier, Cornelia Kraus, Miriam S. Reuter, Steffen Uebe, Mary-Alice Abbott, Syed A. Ahmed, Kristyn L. Rawson, Eileen Barr, Hong Li, Ange-Line Bruel, Laurence Faivre, Frederic Tran Mau-Them, Christina Botti, Susan Brooks, Kaitlyn Burns, D. Isum Ward, Marina Dutra-Clarke, Julian A. Martinez-Agosto, Hane Lee, Stanley F. Nelson, Pia Zacher, Rami Abou Jamra, Chiara Kloeckner, Julie McGaughran, Juergen Kohlhase, Sarah Schuhmann, Ellen Moran, John Pappas, Annick Raas-Rothschild, Maria J. Guillen Sacoto, Lindsay B. Henderson, Timothy Blake Palculict, Sureni Mullegama, Houda Zghal Elloumi, Adi Reich, Samantha A. Schrier Vergano, Erica Wahl, Andre Reis, Christiane Zweier
Summary: The study identified an EIF3F variant associated with neurodevelopmental disorder, characterized by intellectual disability, epilepsy, and other symptoms. Patients showed developmental delays, behavioral problems, hearing loss, and short stature, with some also exhibiting microcephaly and reduced sensitivity to pain. A compound heterozygous individual had severe symptoms, suggesting genotype-phenotype correlation.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Oncology
Mandi L. Pratt-Chapman, Yan Wang, Kristen Eckstrand, Asa Radix, Gwendolyn P. Quinn, Matthew B. Schabath, Ana Maria Lopez
Summary: To address health disparities in sexual and gender minority (SGM) patients, it is important to provide education and training for cancer care professionals. This study examines the outcomes of healthcare professionals who participated in the TEAM SGM pilot intervention.
JOURNAL OF CANCER EDUCATION
(2023)
Article
Behavioral Sciences
Luis E. Flores, Gabriela Alarcon, Kristen L. Eckstrand, Morgan Lindenmuth, Erika E. Forbes
Summary: This study explores the roles of interpersonal behaviors and tendencies in neural response to aversive stimuli.
BRAIN AND BEHAVIOR
(2022)
Article
Neurosciences
Judith K. Morgan, Kristen L. Eckstrand, Jennifer S. Silk, Thomas M. Olino, Cecile D. Ladouceur, Erika E. Forbes
Summary: Offspring of depressed parents show reduced neural response to winning reward in the ventral striatum. Neural reward alterations may emerge earlier than expected, as early as 6-8 years old, particularly in the context of maternal discouragement of child positive emotion. Clinical interventions that focus on coaching mothers to encourage child positive emotions could support child reward-related brain development.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Editorial Material
Clinical Neurology
Jessica M. Gannon, Kristen Eckstrand, Vernon Nathaniel
Article
Public, Environmental & Occupational Health
Mandi L. Pratt-Chapman, Kristen Eckstrand, Amorie Robinson, Lauren B. Beach, Charles Kamen, Alex S. Keuroghlian, Scott Cook, Asa Radix, Markus P. Bidell, Daniel Bruner, Liz Margolies
Summary: This article describes a collaborative process to provide core cultural competency recommendations for training healthcare and social service providers for LGBTQIA+ patients. The recommendations, developed through a synthesis of research, training, and stakeholder feedback, focus on knowing the audience, developing and fine-tuning the curriculum, employing different learning theories, choosing effective trainers, and evaluating the impact of training. These recommendations contribute to advancing SGD health equity in healthcare and social services.
Review
Education, Scientific Disciplines
Janke B. Mains-Mason, Eloho Ufomata, J. Klint Peebles, Cherie P. Dhar, Gina Sequeira, Rebekah Miller, Barbara Folb, Kristen L. Eckstrand
Summary: Through a systematic review, this study identified limited medical education curricula for the healthcare of SGM/DSD individuals. These curricula primarily focused on knowledge retention and clinical skills acquisition, but few fully aligned with the AAMC's SGM/DSD competency recommendations. Additionally, there was no inclusion of teaching SGM/DSD healthcare for individuals with multiply minoritized identities or engaging the broader SGM/DSD community in curriculum development and implementation.
Editorial Material
Neurosciences
Kristen L. Eckstrand, Manpreet K. Singh, Olu Ajilore
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Psychology, Multidisciplinary
Christine C. Call, Kristen L. Eckstrand, Steven W. Kasparek, Cassandra L. Boness, Lorraine Blatt, Nabila Jamal-Orozco, Derek M. Novacek, Dan Foti
Summary: This article discusses the ethical and social justice issues associated with the use of demographic data in psychology and introduces a framework to help psychologists and researchers in social science make thoughtful decisions.
PERSPECTIVES ON PSYCHOLOGICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Rebecca Green, Kristen L. Eckstrand, Morgan Faeder, Sarah Tilstra, Eloho Ufomata
MEDICAL CLINICS OF NORTH AMERICA
(2023)
Meeting Abstract
Neurosciences
Kristen Eckstrand
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Neurosciences
Kristen Eckstrand, Erika Forbes, Michele Bertocci, Henry Chase, Jeanette Lockovich, Richelle Stiffler, Haris Aslam, Alex Skeba, Simona Graur, Genna Bebko, Mary Phillips
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Neurosciences
Carly Lenniger, M. Nicole Buckley, Alyssa Brostowin, Kristen Eckstrand, Erika Forbes
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Kristen Eckstrand, M. Nicole Buckley, Melissa Nance, Morgan Lindenmuth, Gaby Alarcon, Neal Ryan, Neil Jones, Michael Marshal, Jennifer Silk, Mary Phillips, Erika Forbes
BIOLOGICAL PSYCHIATRY
(2022)
Review
Psychology, Multidisciplinary
Brian C. Thoma, Kristen L. Eckstrand, Gerald T. Montano, Taylor L. Rezeppa, Michael P. Marshal
Summary: Research shows that gender nonconformity is associated with LGB individuals experiencing more prejudice events, less concealment of sexual orientation, lower internalized homonegativity, and a higher expectation of rejection related to sexual orientation. The association between gender nonconformity and prejudice events is stronger among gay and bisexual men compared to lesbian and bisexual women. Gender nonconformity is systematically linked to minority stress experiences among LGB individuals, with future research needing to further explore this relationship in order to understand the impact on health outcomes within LGB populations.
PERSPECTIVES ON PSYCHOLOGICAL SCIENCE
(2021)
