Article
Immunology
Li Yin, Xiaomin Wei, Yanjun Zhang, Chengshu Lu, Huakun Wang
Summary: The aim of this study was to investigate the effect of citrulline on the pyroptosis of mouse macrophage RAW264.7 and the mechanism. The results showed that citrulline promoted cell viability and inhibited LPS-induced pyroptosis of RAW264.7 cells. Furthermore, citrulline inactivated the NF-κB/p65 signaling pathway by suppressing p65 nuclear translocation induced by LPS. Therefore, the inhibition of pyroptosis induced by citrulline may be closely related to the inactivation of the NF-κB/p65 signaling pathway.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Medicine, Research & Experimental
Xiaoyu Zhang, Yuan Kang, Ximeng Li, Yunfeng Huang, Ruijuan Qi, Yixin Han, Runlan Cai, Yuan Gao, Yun Qi
Summary: Potentilla discolor Bunge (PD) is a traditional Chinese medicine with strong anti-inflammatory effects by suppressing the expressions of iNOS, TNF-α, and MCP-1, as well as inhibiting the activation of NF-kappa B and AP-1. The ethanol extract of the whole herbs of PD (EPD) shows promising therapeutic potential for inflammatory diseases, especially intestinal inflammation, through its ability to modulate inflammatory mediators and signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Zhanqi Zhang, Yiwen Zhang, Yongjie Cai, Di Li, Jinlin He, Zhihui Feng, Qiong Xu
Summary: Periodontitis is a chronic inflammatory disease caused by bacterial pathogens and the immune response. Macrophages play a crucial role in the development of periodontitis. NAT10 was found to be downregulated in macrophages during LPS-induced inflammation. Knockdown of NAT10 reduced the production of inflammatory factors, while overexpression of NAT10 had the opposite effect.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Jin-Kyu Kang, You-Chul Chung, Chang-Gu Hyun
Summary: The study demonstrated that 6-MC reduced the levels of nitric oxide and prostaglandin E-2 without causing cytotoxicity, and also decreased the expression of pro-inflammatory cytokines in a concentration-dependent manner in LPS-stimulated cells. Western blot results showed that 6-MC treatment decreased the protein levels of iNOS and COX-2 induced by LPS, while mechanistic studies revealed its inhibitory effects on the MAPK and NF-kappa B pathways.
Article
Immunology
Jiajing Zhao, Prasanta Roy, Haimei Tang, Xingyu Ma, Qianqian Di, Jiazheng Quan, Yonghong Guan, Xiaoli Li, Weilie Xiao, Weilin Chen
Summary: This study demonstrated the anti-inflammatory effects of XCR-5a both in vitro and in vivo, showing its ability to suppress pro-inflammatory cytokines production and inhibit immune cell infiltration by suppressing NF-kappa B signaling activation. XCR-5a could be a potential drug candidate for treating inflammatory diseases.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Immunology
Zhiyan Zhou, Ranhui Xi, Jiaxin Liu, Xian Peng, Lei Zhao, Xuedong Zhou, Jiyao Li, Xin Zheng, Xin Xu
Summary: The study identified multiple subtypes of taste receptors in human gingival fibroblasts and highlighted TAS2R16's role in inhibiting pro-inflammatory responses by regulating NF-kappa B signaling. This provides a new target and paradigm for the treatment of periodontitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Zhending Gan, Meiyu Zhang, Donghui Xie, Xiaoyan Wu, Changming Hong, Jian Fu, Lijuan Fan, Shengyi Wang, Sufang Han
Summary: Glycine, acting as an inhibitory neurotransmitter, not only affects the functions of macrophages but also shapes their polarization through cellular signaling pathways and microRNAs. Additionally, glycine has beneficial effects in preventing and treating macrophage-associated diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dan Huang, Chaoqun Sun, Min Chen, Shuyou Bai, Xuanna Zhao, Weiming Wang, Kang Geng, Wenbo Huang, Tingting Zhao, Bin Wu, Guilin Zhang, Dong Wu, Youhua Xu
Summary: This study found that the SIRT1 agonist bergenin can improve asthma-induced airway inflammation and remodeling by activating SIRT1 and regulating the transcriptional activity of nuclear factor kappa B.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bingyu Shen, Haoqing Zhang, Zhengjin Zhu, Zixi Ling, Fangyuan Zeng, Yazhou Wang, Jianguo Wang
Summary: Baicalin, extracted from Scutellaria, has anti-inflammatory effects and can reduce pulmonary edema caused by ALI. It inhibits the expression of TLR4 and MyD88, leading to a decrease in inflammatory molecules. Baicalin also promotes an increase in white blood cells and improves lung pathology, indicating its potential as a treatment for ALI.
Article
Immunology
Kaihe Xiang, Peng Shen, Ziyang Gao, Zhuoyu Liu, Xiaoyu Hu, Bin Liu, Yunhe Fu
Summary: Formononetin (FOR), a natural flavonoid, has been shown to have anti-inflammatory and anti-oxidative effects. This study investigated the protective mechanism of FOR against LPS-induced mastitis and found that it inhibits inflammation and enhances blood-milk barrier integrity through the AhR-induced Src inactivation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jaejin Shin, Leo Sungwong Choi, Hyun Ju Jeon, Hyeong Min Lee, Sang Hyo Kim, Kwan-Woo Kim, Wonmin Ko, Hyuncheol Oh, Hyung Soon Park
Summary: This study investigated the anti-inflammatory effects of synthetic glabridin derivatives in LPS-stimulated macrophages. The derivatives suppressed the production of pro-inflammatory factors and inhibited the activation of MAPKs and NF-kappa B pathways. These findings suggest that glabridin derivatives may be potential therapeutics for inflammatory diseases.
Article
Immunology
Pengcheng Cui, Chao Chen, Yan Cui, Xia Qiu, Kaiye Yue, Tengfang Li, Hedong Zhang, Wenjia Yuan, Yixin Xie, Yong Guo, Zhouqi Tang, Yaguang Li, Fenghua Peng, Xin Jiang, Xuewei Luo, Longkai Peng, Zhongquan Qi, Helong Dai
Summary: DsbA-L protein promotes AKI by upregulating voltage-dependent anion-selective channels in proximal tubular cells. However, its role in immune cells remains unclear. This study found that DsbA-L deletion attenuates LPS-induced AKI and affects arginine metabolism and inflammatory cytokines, potentially through the NF-κB/AP-1 pathway.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Hanyu Shen, Ziheng Wang, Ailong Huang, Dandan Zhu, Pingping Sun, Yinong Duan
Summary: Schistosomiasis, a tropical zoonotic parasitic disease caused by schistosomes, primarily affects the intestines and liver, where parasite eggs induce immune responses leading to liver fibrosis and granulomatous reactions. Differential gene expression analysis suggests LCN2 plays a significant role in early S. japonicum infection, with in vivo experiments showing upregulation in infected liver tissues. Further research indicates that NF-kappa B/LCN2 signaling is crucial for M1 macrophage polarization in response to infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Plant Sciences
Weiwei Zhu, Wu Luo, Jibo Han, Qiuyan Zhang, Lijun Ji, Aleksandr V. Samorodov, Valentin N. Pavlov, Zaishou Zhuang, Daona Yang, Lina Yin, Lijiang Huang, Guang Liang, Joo Young Huh, Yi Wang
Summary: This study investigated the anti-inflammatory mechanism of Schisandrin B (Sch B) in macrophages and an animal model of acute lung injury (ALI) and found that Sch B directly binds to MyD88 to regulate inflammatory responses and inhibit the expression of inflammatory factors. The study suggests that Sch B has therapeutic potential for ALI and other MyD88-dependent inflammatory diseases.
Article
Biochemistry & Molecular Biology
Shu Yang, Jianhong Wang, Duozi Wang, Lei Guo, Dalin Yu
Summary: Ramelteon ameliorates LPS-induced inflammatory responses in astrocytes by reducing expressions of inflammatory cytokines and inhibiting the TLR4/I kappa B alpha/NF-kappa B p65 axis, suggesting its potential as a protective agent against LPS-induced damage in astrocytes.
ACS CHEMICAL NEUROSCIENCE
(2021)
