Article
Materials Science, Multidisciplinary
Zhaoying Liu, Shurui Pei, Kaikai Wen, Aidong Peng, Han Ma, Hui Huang
Summary: A novel fluorescent probe targeting malignant melanoma has been developed for early diagnosis through in vivo imaging. The probe exhibited significant tissue penetration, photostability, and specific targeting properties, making it an excellent nano-platform for early melanoma diagnosis.
SCIENCE CHINA-MATERIALS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yubin Miao, Thomas P. Quinn
Summary: The study discusses the potential of using MC1R and VLA-4 as targeted peptides and highlights the innovative advances in related peptides and peptide conjugates for melanoma imaging and therapy, providing hope for future clinical translation.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ren-Lei Ji, Ya-Xiong Tao
Summary: Two new human MRAP2 splice variants were identified in this study, and the effects of MRAP1 and MRAP2 on MC3R and MC4R were investigated. The results suggest that MRAPs play important roles in the signaling and regulation of neural MC3R and MC4R.
Article
Immunology
John Dodd, Robert Jordan, Marie Makhlina, Keith Barnett, Ad Roffel, Carl Spana, Alison Obr, Priyanka Dhingra, Paul S. Kayne
Summary: PL8177 is a potent and selective agonist of MC1R, and it has been shown to reverse intestinal inflammation in a rat ulcerative colitis model. A novel polymer-encapsulated formulation of PL8177 was developed for oral delivery and tested in rat and dog models, as well as in humans, for distribution and concentration within the gastrointestinal tract.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jingjing Yu, Xu Zhou, Langtao Shen
Summary: C-X-C chemokine receptor type 4 (CXCR4) plays a crucial role in various diseases, including HIV infection, inflammatory diseases, and metastatic cancer. The overexpression of CXCR4 is closely related to tumor aggressiveness and increased risks of metastasis and recurrence. Therefore, researchers have been exploring CXCR4-targeted imaging and therapeutic approaches.
Article
Biochemistry & Molecular Biology
Ren-Lei Ji, Shan-Shan Jiang, Ya-Xiong Tao
Summary: The neural melanocortin receptors (MCRs) and their accessory proteins MRAP1 and MRAP2 play crucial roles in regulating energy homeostasis. This study reveals that MRAP1 and MRAP2s have species-specific effects on canine neural MCRs, providing a better understanding of their regulation.
Review
Biochemistry & Molecular Biology
Yoonwoo Mun, Woohyun Kim, Dongyun Shin
Summary: Melanocortins, particularly the melanocortin 1 receptor (MC1R), have significant roles in regulating stress response, inflammation, and skin pigmentation. This review provides an overview of MC1R's structure, signaling pathways, associated diseases, and highlights the therapeutic potential of synthetic peptides and small molecule modulators. MC1R-targeted drugs have applications beyond skin pigmentation-related diseases, with potential in treating inflammatory diseases by targeting MC1R expression in various cells. Further research in this area is encouraged.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Dennis Pedersbaek, Louise Krogager, Camilla Hald Albertsen, Lars Ringgaard, Anders E. Hansen, Katrine Jonsson, Jannik B. Larsen, Andreas Kjaer, Thomas L. Andresen, Jens B. Simonsen
Summary: The study found that PEGylation of the b-HDL scaffold had minimal effect on the biological fate of the lipids, with both b-HDL and PEG b-HDL sharing similar biological fates including cellular uptake and tumor accumulation. This highlights the dynamic nature of b-HDL particles, where the biological fate of the components (lipids and scaffold) can differ. A phenomenon that may also apply to other multicomponent nanoparticles.
Article
Biotechnology & Applied Microbiology
Wei Xiong, Zhengdong Guo, Baoyan Zeng, Teng Wang, Xiaowei Zeng, Wei Cao, Daizheng Lian
Summary: This study constructed multifunctional nanoparticles for the encapsulation of dacarbazine (DTIC) and targeted therapy of malignant melanoma (MM). In vitro and in vivo experiments showed that these nanoparticles had good release properties and exhibited strong anti-tumor effects with no side effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hua Ma, Iris Y. Zhou, Y. Iris Chen, Nicholas J. Rotile, Ilknur Ay, Eman A. Akam, Huan Wang, Rachel S. Knipe, Lida P. Hariri, Caiyuan Zhang, Matthew Drummond, Pamela Pantazopoulos, Brianna F. Moon, Avery T. Boice, Samantha E. Zygmont, Jonah Weigand-Whittier, Mozhdeh Sojoodi, Romer A. Gonzalez-Villalobos, Michael K. Hansen, Kenneth K. Tanabe, Peter Caravan
Summary: We report on three Mn(II)-based small-molecule magnetic resonance probes containing α-effect nucleophiles to target allysine in vivo and detect tissue fibrogenesis. The design approach resulted in turn-on probes with a 4-fold increase in relaxivity upon targeting. The probes' performance in detecting tissue fibrogenesis was evaluated using a systemic aldehyde tracking approach, showing efficiency in characterizing fibrogenesis throughout the lung and liver.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Oncology
Hanine Rafidi, Alberto Estevez, Gregory Z. Ferl, Danielle Mandikian, Shannon Stainton, Lauren Sermeno, Simon P. Williams, Amrita Kamath, James T. Koerber, C. Andrew Boswell
Summary: Advances in antibody engineering have allowed the construction of novel molecular formats, providing new opportunities for cancer immunotherapy drug discovery, but also revealing limitations in knowledge of structure-activity relationships. By constructing a representative library and using different shapes and hinge flexibilities of IgG-like formats, it was found that one-armed antibodies have higher renal uptake compared to bivalent antibodies.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Chemistry, Medicinal
Ayoung Pyo, Misun Yun, Boreum Song, Seong-Young Kwon, Jung-Joon Min, Dong-Yeon Kim
Summary: In this study, 18F-labeled procainamide (PCA) was synthesized and evaluated for its potential as a PET imaging agent for melanoma detection. The results showed that 18F-PCA exhibited high melanoma uptake and could be a promising tool for direct melanoma detection using PET imaging.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Multidisciplinary Sciences
Hanwen Zhang, Diane Abou, Peng Lu, Abbie Meghan Hasson, Alexandria Villmer, Nadia Benabdallah, Wen Jiang, David Ulmert, Sean Carlin, Buck E. Rogers, Norman F. Turtle, Michael R. McDevitt, Brian Baumann, Brian W. Simons, Farrokh Dehdashti, Dong Zhou, Daniel L. J. Thorek
Summary: Noninvasive imaging has great potential to guide α-particle therapy. In this study, [F-18]-PARPZ radiotracer was used to delineate castrate resistant prostate cancer xenografts, showing its ability to distinguish treated from control groups and further understand DNA damage response.
SCIENTIFIC REPORTS
(2022)
Article
Nanoscience & Nanotechnology
Liangdi Jiang, Yongwei Gu, Yue Du, Xiaomeng Tang, Xin Wu, Jiyong Liu
Summary: The study proposes a delivery system based on TRAIL-engineered exosomes (TRAIL-Exo) for loading TPL for targeted therapy against malignant melanoma, which improves tumor targetability, enhances cellular uptake, inhibits proliferation, invasion, and migration, and induces apoptosis of A375 cells through activating the extrinsic TRAIL pathway and the intrinsic mitochondrial pathway in vitro. Intravenous injection of TRAIL-Exo/TPL significantly suppresses tumor progression and reduces the toxicity of TPL in the melanoma nude mouse model, presenting a novel strategy for high-efficiency exosome-based drug-delivery nanocarriers with synergistic therapeutic efficacy and targeting capacity for melanoma treatment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biophysics
Elahehnaz Parhizkar, Soliman Mohammadi Samani, Amirhossein Sakhteman, Saeid Daneshamouz, Golnaz Parhizkar, Fatemeh Ahmadi
Summary: Prodrugs, especially folate conjugates, demonstrate higher cytotoxicity and longer serum residence time compared to free CTX. Tissue accumulation data shows liver as the major organ for CTX. Data modeling analysis reveals significant differences in pharmacokinetics properties between CTX and prodrugs, suggesting promise as a potential CTX delivery system.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Oncology
Daniel Verduzco, Brent M. Kuenzi, Fumi Kinose, Vernon K. Sondak, Zeynep Eroglu, Uwe Rix, Keiran S. M. Smalley
MOLECULAR CANCER THERAPEUTICS
(2018)
Article
Oncology
Manali Phadke, Lily L. Remsing Rix, Inna Smalley, Annamarie T. Bryant, Yunting Luo, Harshani R. Lawrence, Braydon J. Schaible, Yian A. Chen, Uwe Rix, Keiran S. M. Smalley
MOLECULAR ONCOLOGY
(2018)
Editorial Material
Pharmacology & Pharmacy
Keiran S. M. Smalley, Peter A. Forsyth
PHARMACOLOGICAL RESEARCH
(2018)
Review
Pharmacology & Pharmacy
Daniel Abate-Daga, Maria C. Ramello, Inna Smalley, Peter A. Forsyth, Keiran S. M. Smalley
BIOCHEMICAL PHARMACOLOGY
(2018)
Letter
Oncology
Sarah Sloot, Yian A. Chen, Xiuhua Zhao, Jamie L. Weber, Jacob J. Benedict, James J. Mule, Keiran S. Smalley, Jeffrey S. Weber, Jonathan S. Zager, Peter A. Forsyth, Vernon K. Sondak, Geoffrey T. Gibney
Article
Oncology
Jessica Goncalves, Michael F. Emmons, Fernanda Faiao-Flores, Andrew E. Aplin, J. William Harbour, Jonathan D. Licht, Marcia R. Wink, Keiran S. M. Smalley
PIGMENT CELL & MELANOMA RESEARCH
(2020)
Review
Oncology
Isabella C. Glitza, Keiran S. M. Smalley, Priscilla K. Brastianos, Michael A. Davies, Ian McCutcheon, James K. C. Liu, Kamran A. Ahmed, John A. Arrington, Brittany R. Evernden, Inna Smalley, Zeynep Eroglu, Nikhil Khushalani, Kim Margolin, Harriet Kluger, Michael B. Atkins, Hussein Tawbi, Adrienne Boire, Peter Forsyth
PIGMENT CELL & MELANOMA RESEARCH
(2020)
Article
Dermatology
Chao Zhang, Inna Smalley, Michael F. Emmons, Ritin Sharma, Victoria Izumi, Jane Messina, John M. Koomen, Elena B. Pasquale, Peter A. Forsyth, Keiran S. M. Smalley
Summary: The acquired BRAF inhibitor resistance in melanoma is associated with a new transcriptional state leading to increased metastatic risk, driven by noncanonical EphA2 signaling and mesenchymal-to-amoeboid transition. Histone deacetylase 8 activity is crucial for the drug-resistant metastatic state, affecting melanoma-endothelial cell interactions and tumor dissemination.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Review
Dermatology
Manali Phadke, Alpaslan Ozgun, Zeynep Eroglu, Keiran S. M. Smalley
Summary: The development of brain metastases is the deadliest complication of advanced melanoma, and recent progress has been made in therapies for melanoma brain metastases (MBM). However, there are lower response durations for intracranial metastases compared to extracranial metastases, possibly due to unique features of the brain microenvironment. Current research focuses on the biology and pathophysiology of melanoma brain metastasis development, as well as the challenges faced in clinical trials and treatment for MBM patients.
EXPERIMENTAL DERMATOLOGY
(2022)
Editorial Material
Oncology
Inna Smalley, Keiran S. M. Smalley
Summary: In this study, the authors used RNA sequencing and multiplexed IHC to analyze the spatial immune landscape of melanoma patients. They found that the spatial interaction between cytotoxic T cells and M1-like macrophages expressing PD-L1 can predict the response to immune checkpoint inhibition.
Editorial Material
Oncology
Keiran S. M. Smalley
CLINICAL CANCER RESEARCH
(2023)
Editorial Material
Oncology
Manali S. S. Phadke, Keiran S. M. Smalley
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Inna Smalley, Adrienne Boire, Priscilla Brastianos, Harriet M. Kluger, Eva Hernando-Monge, Peter A. Forsyth, Kamran A. Ahmed, Keiran S. M. Smalley, Sherise Ferguson, Michael A. Davies, Isabella C. Glitza Oliva
Summary: Leptomeningeal disease (LMD) is a major challenge in the clinical management of metastatic melanoma patients. Recent trials have demonstrated the feasibility of conducting prospective clinical trials in these patients, and new insights into the pathophysiology of LMD are identifying rational new therapeutic strategies.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Review
Oncology
Larissa Anastacio DaCosta Carvalho, Flavia C. Aguiar, Keiran S. M. Smalley, Patricia A. Possik
Summary: Acral melanoma is a rare subtype of melanoma that is not linked to sun exposure. Recent studies have begun to explore the genetics and immune features of acral melanoma, which can provide guidance for therapeutic management.
Article
Oncology
Sarah Sloot, Yian A. Chen, Xiuhua Zhao, Jamie L. Weber, Jacob J. Benedict, James J. Mule, Keiran S. Smalley, Jeffrey S. Weber, Jonathan S. Zager, Peter A. Forsyth, Vernon K. Sondak, Geoffrey T. Gibney