Article
Polymer Science
Tao Lin, Dandan Chen, Yan Geng, Jiayu Li, Yanghui Ou, Zhijun Zeng, Canqiang Yin, Xudong Qian, Xiang Qiu, Gang Li, Yali Zhang, Wen Guan, Mengjie Li, Xiaojia Cai, Jiaqiang Wu, Wen-Hua Chen, Yan-Qing Guan, Hongliang Yao
Summary: In this study, a compound with anti-inflammatory activity, 3J, was synthesized and incorporated into an intelligent composite hydrogel for the treatment of oral ulcers. The hydrogel exhibited a dense honeycomb structure for effective drug loading and wound ventilation, as well as biodegradability. It showed antibacterial effects, reduced inflammatory cytokine levels, and had excellent swelling and water retention properties, making it a promising treatment for oral ulcers.
Article
Chemistry, Applied
Li-Yuan Huang, Wen Li, Nan Du, Hai-Qin Lu, Li-Dan Meng, Ke-Yu Huang, Kai Li
Summary: In this study, novel green in situ quaternary-ammonium-functionalized magnetic chitosan microspheres (IQMCM) were synthesized and characterized. The IQMCMs showed spherical morphology, superior thermal stability, magnetic properties, and surface charges. The adsorption capacities of the IQMCM microspheres to Congo red dye were high, and the adsorption process was spontaneous, endothermic, and monolayer chemisorption. The magnetic adsorbent could be easily separated and reused with little capacity loss, indicating the potential application of IQMCMs in wastewater treatment.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Wanjing Zou, Jingwei Gu, Jianna Li, Yuanfang Wang, Shiguo Chen
Summary: The study successfully synthesized IQAS and ISB derivatives and systematically investigated the effects of their substitution degree, carbon chain length, and content ratio on water solubility, antibacterial activity, and cytotoxicity of CS derivatives, suggesting that the properties of CS derivatives can be tailored by adjusting the amount of grafted antibacterial agents.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Thev Pol, Wunpen Chonkaew, Lalintip Hocharoen, Nakorn Niamnont, Namphueng Butkhot, Yaowaluck Maprang Roshorm, Suda Kiatkamjornwong, Voravee P. Hoven, Kornkanya Pratumyot
Summary: Amphiphilic chitosan derivative bPalm-CS-HTAP was synthesized and found to self-assemble into nanosized particles. It effectively condensed plasmid DNA and enabled gene expression in cells without causing cytotoxicity, making it a promising nonviral gene carrier.
Article
Biochemistry & Molecular Biology
Zonghua Tian, Xia Wu, Li Peng, Na Yu, Guojing Gou, Wenbao Zuo, Jianhong Yang
Summary: In this study, pH-responsive bufadienolides nanocrystals decorated by chitosan quaternary ammonium salt (HE BU NCs) were successfully constructed to improve the bioavailability, release characteristics, and intestinal transport ability of bufadienolides. In vitro studies showed that HE BU NCs could improve the internalization of bufadienolides, induce apoptosis, decrease mitochondrial membrane potential, and increase ROS levels in tumor cells. In vivo experiments demonstrated that HE BU NCs effectively targeted intestinal sites, increased retention time, and exerted antitumor activity through Caspase-3 and Bax/Bcl-2 ratio pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Liqiu Chu, Zhiyu Zhou, Zhipan Feng, Xinqi Zhao, Huimin Tan, Yu Chen
Summary: In this study, HTCC/Fe3O4/CdTe magnetic fluorescent nanoparticles (MFCNPs) that can be well dispersed in water were prepared via electrostatic interaction. The nanoparticles showed good biocompatibility and their properties were mainly influenced by the relative ratios of different components. The chitosan-based magnetic fluorescent composite may be a promising delivery carrier candidate.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Polymer Science
Baiqing Song, Tianyi Zhang, Xinfeng Li, Kaili Yang, Jinyu Shan, Yunzhi Dang, Jianhua Ma
Summary: Smart and controllable antibacterial fabrics have great potential in textile, medical, and healthcare fields. In this study, a composite antimicrobial fiber with thermally responsive properties was created by synthesizing nano zinc oxide (ZnO) and combining it with quaternary ammonium chitosan (QAC). The addition of a copper sulphide (CuS) layer further enhanced the antibacterial properties of the materials. These smart responsive composite fibers show promise in medical dressings, special textiles, and healthcare materials.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Hongcai Zhang, Tingting Qiu, Yifei Bai, Bin Chen, Juan Yan, Jianxiong Xu
Summary: In this study, cellulose nanocrystals were used to stabilize Lysozyme encapsulated in quaternary ammonium chitosan nanoparticles. The CNC stabilized Lys loaded QC NPs showed potential implications in the food industry for food preservation and packaging, as well as demonstrated good antibacterial activity against Staphylococcus aureus and Vibrio parahaemolyticus.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Energy & Fuels
Chenglong Li, Geng Liu, Shuang Wang, Di Wang, Fengxiang Liu, Yinghe Cui, Dan Liang, Xiaodong Wang, Zhipeng Yong, Yue Chi
Summary: A hydrogel electrolyte with excellent electrochemical and sensing performance was prepared. The hydrogel is composed of a highly cross-linked network formed by quaternary ammonium side chain chitosan and polyvinyl alcohol, and the device is assembled with activated carbon electrodes. After 5000 charge/discharge cycles, the capacitance retention rate of the supercapacitor device remained as high as 92.5%. Additionally, the gel exhibited outstanding sensing ability, with a sensing factor of 0.995 and a response time of 180 ms, which could still be maintained after multiple cycles.
JOURNAL OF ENERGY STORAGE
(2022)
Article
Chemistry, Physical
Samantha E. Mackay, Francois Malherbe, Daniel S. Eldridge
Summary: Phosphate contamination from agricultural runoff is a major global issue that has severe environmental effects. This study presents a synthesized biopolymer that can effectively remediate phosphate in the environment. The modified-chitosan not only demonstrates a high adsorption capacity but also shows remarkable regenerability.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Polymer Science
Xi Zhang, Xiangli Kong, Xin Zhou, Yiyan Gao, Yibo Sun, Guanghui Gao, Wei Liu, Kai Shi
Summary: Conductive hydrogels have great development prospects in flexible strain sensors, but long-term direct contact with human skin can cause bacterial infection. A hydrogel with antibacterial, biocompatibility, and toughness was designed and manufactured using a freeze-thaw method. The hydrogel maintains tensile properties and fatigue resistance at low temperatures and is resistant to bacteria. Therefore, hydrogel sensors can be used to monitor human movements.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Biochemistry & Molecular Biology
Yanbing Song, Jin Xing, Li Ren, Xia Xu, Donghua Han, Hao Xu, Liang Zhao, Yang Yu, Shige Wang, Chaobo Liu
Summary: A multi-functional hydrogel with antibacterial properties, hemostasis, and the ability to promote wound healing is proposed in this study. The hydrogel is composed of surfactin, polyvinylpyrrolidone, and methacrylic anhydride grafted quaternary ammonium chitosan. The formation of the hydrogel is triggered by ultraviolet-initiated polymerization, while surfactin is complexed with the hydrogel through hydrogen bonding interaction. This adhesive hydrogel with shape adaptability can cover the wound surface, simulate the microenvironment of the primary extracellular matrix, and promote collagen deposition and inflammatory factor transformation.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Polymer Science
Abolfazl Heydari, Eva Dusicka, Matej Micusik, Marian Sedlak, Igor Lacik
Summary: In this study, the characteristics of N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan salt (HTCS) were investigated, revealing a significant exchange of chloride counterions during synthesis, with the true degree of quaternization determined by NMR spectroscopy. This phenomenon of counterion exchange was further validated by XPS and shown for quaternized dextran, highlighting the importance of considering counterion type in applications of polyelectrolytes.
Article
Chemistry, Physical
Maria Jose G. de Araujo, Francivandi C. Barbosa, Marcus Vinicius L. Fook, Suedina Maria L. Silva, Itamara F. Leite
Summary: In this study, an antimicrobial packaging material was successfully developed by melt processing blends of high-density polyethylene (HDPE) and chitosan (CS). The effect of chitosan content (up to 40%) and the addition of quaternary ammonium salt functionalized chitosan (CS-CTAB) as an additive were evaluated. The results showed that HDPE/CS composites with 10% and 20% chitosan exhibited better elongation values and higher thermal stability, and the additive acted as an antimicrobial agent, making the composites suitable for food packaging.
Article
Biochemistry & Molecular Biology
Linyu Nian, Yao Xie, Xiaoyang Sun, Mengjun Wang, Chongjiang Cao
Summary: In this study, a multifunctional packaging biopolymer-based film (CMCGF) was developed using a modified metal-organic framework (MOF) and a blended matrix of chitosan quaternary ammonium salt (CQAS)/gelatin. The CMCGF film showed improved physicochemical properties and had a higher ethylene adsorption performance compared to the control film (CGF). The release of Cu ions from CMCGF resulted in bacterial death, with an antibacterial efficiency of 97-100% against E. coli and 98-100% against S. aureus. Postharvest storage experiments confirmed the high-efficiency preservation effect of CMCGF packaging on tomato and winter jujube. Therefore, CMCGF provides a multifunctional approach to extend the shelf-life of perishable products and reduce food wastage.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Microbiology
Abdulghani Alakkad, Paul Stapleton, Corinna Schlosser, Sudaxshina Murdan, Uchechukwu Odunze, Andreas Schatzlein, Ijeoma F. Uchegbu
Summary: This study found that nanoparticulate amphotericin B (AmB) has strong activity against Candida biofilms and can penetrate the biofilm matrix and bind to fungal cells. MET-AmB eye drops were stable at room temperature, and these findings may help address refractory ocular fungal infections and other Candida biofilm infections.
Article
Pharmacology & Pharmacy
Asya Petkova, Ilona Kubajewska, Alexandra Vaideanu, Andreas G. Schatzlein, Ijeoma F. Uchegbu
Summary: Gene delivery to the cerebral cortex can be achieved via intranasal administration of hyaluronidase-coated polyplexes (GCPH).
Article
Pharmacology & Pharmacy
Dien Puji Rahayu, Roger Draheim, Aikaterini Lalatsa, Marta Roldo
Summary: Dental caries is a worldwide endemic chronic disease, and there is a need for new, effective, safe, and affordable oral products. A polymer (CS3H Lys F) has been found to have strong antibacterial properties and the ability to protect teeth from acid demineralization, making it a potential candidate for oral hygiene products.
Review
Chemistry, Multidisciplinary
Ryan D. Mellor, Ijeoma F. Uchegbu
Summary: This article reviews the applications of gold nanoparticles in the field of nanotechnology. By tuning the particle size, their physicochemical properties can be controlled, allowing for various applications in vivo. The effects of particle size on optical properties, opsonization, cellular internalization, renal clearance, biodistribution, tumor accumulation, and toxicity are discussed in detail.
Review
Materials Science, Biomaterials
Karim Osouli-Bostanabad, Tahereh Masalehdan, Robert M. I. Kapsa, Anita Quigley, Aikaterini Lalatsa, Kiara F. Bruggeman, Stephanie J. Franks, Richard J. Williams, David R. Nisbet
Summary: This article discusses the potential and challenges of 3D printing and 3D bioprinting in healthcare, highlighting their promise in the fields of regenerative medicine, tissue engineering, and drug delivery. The review emphasizes the customization and complexity of 3D-printed products, as well as the ability of 3D bioprinting to fabricate patient-specific tissues and living cell systems. It also discusses the importance of selecting appropriate printing methods and materials, and the potential of 4D-printed strategies to overcome limitations of conventional 3D printing technologies.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Review
Pharmacology & Pharmacy
Karim Osouli-Bostanabad, Sara Puliga, Dolores R. Serrano, Andrea Bucchi, Gavin Halbert, Aikaterini Lalatsa
Summary: Nanoparticulate technologies have revolutionized drug delivery, but their manufacture remains immature. Lipid-based nanomedicines are the most widely approved, but their current manufacturing methods are complex and not easily scalable. The emergence of microfluidic strategies has introduced a paradigm shift in the manufacturing of lipid-based nanomedicines, allowing for tunable and reproducible structure.
Article
Pharmacology & Pharmacy
Miriam Rolon, Eustine Hanna, Celeste Vega, Cathia Coronel, Maria Auxiliadora Dea-Ayuela, Dolores R. Serrano, Aikaterini Lalatsa
Summary: Chagas disease is a parasitic zoonosis that is endemic in Central and South America, and current treatment options are limited. This study presents a new drug delivery system that allows for scalable combined formulations and can be easily converted to oral solid dosage form. The experimental results demonstrate promising efficacy of this new therapy.
Article
Biochemistry & Molecular Biology
Abdullah A. Alamoudi, Paula A. Mendez, David Workman, Andreas G. Schatzlein, Ijeoma F. Uchegbu
Summary: Therapeutic gene silencing in the brain can be achieved through intranasal administration of siRNA-poly(ethylene glycol) based polyplexes. These polyplexes have low toxicity and can effectively silence specific genes in brain cells.
Review
Pharmacology & Pharmacy
Dolores R. Serrano, Aytug Kara, Ivan Yuste, Francis C. C. Luciano, Baris Ongoren, Brayan J. J. Anaya, Gracia Molina, Laura Diez, Bianca I. I. Ramirez, Irving O. O. Ramirez, Sergio A. A. Sanchez-Guirales, Raquel Fernandez-Garcia, Liliana Bautista, Helga K. K. Ruiz, Aikaterini Lalatsa
Summary: 3D printing technologies offer customization of medicine to meet individual patients' needs. Various techniques such as nozzle-based extrusion, laser-writing systems, and powder binder jetting are used to print solid dosage forms, implants, stents, medical devices, and locally applied medicines. The challenge lies in selecting the appropriate 3D printing technique and pharmaceutical ink to ensure desired physicochemical and biological performance. Integration of biopharmaceuticals, nanotechnology-based drugs, and 3D printing opens up new possibilities for personalized nanomedicines. Continuous manufacturing using 3D-printed microfluidic chips facilitates translation into clinical practice.
Article
Pharmacology & Pharmacy
Yvonne Lerchbammer-Kreith, Nadine S. Sommerfeld, Klaudia Cseh, Xian Weng-Jiang, Uchechukwu Odunze, Andreas G. Schaetzlein, Ijeoma F. Uchegbu, Mathea S. Galanski, Michael A. Jakupec, Bernhard K. Keppler
Summary: A new class of anticancer prodrugs was developed by combining platinum(IV) complexes with glycol chitosan polymers as drug carriers. The platinum(IV) complexes were synthesized and conjugated with degraded glycol chitosan (dGC) polymers of different chain lengths. These conjugates exhibited higher cytotoxicity and antiproliferative activity in cancer cell lines compared to platinum(IV) counterparts. In particular, a cisplatin(IV)-dGC conjugate showed the highest cytotoxicity, being 33 times more potent than the corresponding platinum(IV) complex and twice as potent as cisplatin. Biodistribution studies of an oxaliplatin(IV)-dGC conjugate also showed increased accumulation in the lung, suggesting potential for further activity studies.
Article
Pharmacology & Pharmacy
Sarah Kymberly Santos de Lima, italo Novaes Cavallone, Dolores Remedios Serrano, Brayan J. Anaya, Aikaterini Lalatsa, Marcia Dalastra Laurenti, Joao Henrique Ghilardi Lago, Dalete Christine da Silva Souza, Gabriela Pustiglione Marinsek, Beatriz Soares Lopes, Renata de Britto Mari, Luiz Felipe Domingues Passero, Bozena B. Michniak-Kohn
Summary: This study developed a topical formulation containing 8-HQ and demonstrated its efficacy in experimental cutaneous leishmaniasis. The formulation was able to reduce parasite burden and lesion size without causing significant side effects.
Review
Materials Science, Biomaterials
Karim Osouli-Bostanabad, Tahereh Masalehdan, Robert M. I. Kapsa, Anita Quigley, Aikaterini Lalatsa, Kiara F. Bruggeman, Stephanie J. Franks, Richard J. Williams, David R. Nisbet
Summary: This review explores the potential and applications of 3D printing and 3D bioprinting in healthcare, including the production of personalized products, patient-specific tissues, and organ-on-chip constructs. It also discusses how tailoring parameters and adopting dynamic 4D printing strategies can optimize and overcome limitations of conventional 3D printing technologies.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)