Article
Chemistry, Applied
Sanjay Ch, Sri Ganga Padaga, Balaram Ghosh, Sanhita Roy, Swati Biswas
Summary: A mucoadhesive self-assembling polymeric system carrying moxifloxacin was developed for bacterial keratitis treatment. Moxifloxacin-encapsulated mixed micelles (M@CF68/127(5/10)Ms) were prepared using chitosan-PLGA conjugate and poloxamers. The system demonstrated high corneal penetration, mucoadhesiveness, and antibacterial efficacy, with M@CF127(10)Ms showing superior therapeutic effects in P. aeruginosa and S. aureus-infected BK mouse model.
CARBOHYDRATE POLYMERS
(2023)
Article
Biophysics
Sanjay Ch, Priyasha Mishra, Himanshu Bhatt, Balaram Ghosh, Sanhita Roy, Swati Biswas
Summary: In this study, Mox-loaded copolymeric nanoparticles were prepared for the treatment of bacterial keratitis, showing excellent drug loading, mucoadhesion, and antimicrobial activity. The results demonstrate the safety and effectiveness of the drug solution in treating bacterial keratitis.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Physical
Mohamed Nasr, Sameh Saber, Alaa Y. Bazeed, Heba A. Ramadan, Asmaa Ebada, Adela Laura Ciorba, Simona Cavalu, Heba I. Elagamy
Summary: This study demonstrated that the use of cubosomal nanoparticles as a drug delivery system can enhance the corneal permeation of gatifloxacin, reduce the minimum inhibitory concentration, and significantly improve the treatment efficacy for ocular bacterial infections.
Article
Pharmacology & Pharmacy
Anroop B. Nair, Jigar Shah, Shery Jacob, Bandar E. Al-Dhubiab, Vimal Patel, Nagaraja Sreeharsha, Pottathil Shinu
Summary: The study showed that optimizing mucoadhesive buccal films of rizatriptan can enhance its therapeutic efficacy for migraine treatment, with improved drug release and higher plasma levels compared to oral administration. This suggests that buccal films could be a promising alternative approach for effective rizatriptan delivery.
Article
Chemistry, Medicinal
Anwar Ma'ali, Hani Naseef, Moammal Qurt, Abdallah Damin Abukhalil, Abdullah K. Rabba, Israr Sabri
Summary: This research aimed to enhance the absorption of vitamin B-12 using sublingual mucoadhesive tablets. Formula S11 (Eudragit L100-55) was identified as the most favorable formulation with an optimal mucoadhesive residence time and drug release, suggesting an improved bioavailability of vitamin B-12 when this polymer is included.
Article
Pharmacology & Pharmacy
Karin Korelc, Bjarke Strom Larsen, Mirjana Gasperlinb, Ingunn Tho
Summary: Oromucosal films and wafers are convenient solid dosage forms for drug delivery. In this study, prednisolone containing chitosan-based mucoadhesive films and wafers were developed with different chitosan types. The mucoadhesive properties, drug release rate, and permeability of the formulations were evaluated. The results showed that chitosan type, solvent, and preparation method influenced the mucoadhesive properties, drug release rate, and permeability. The mucoadhesive wafers with a slower drug release rate and stronger mucoadhesion were considered promising alternatives to films.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Sachin Nashik Sanap, Amol Chhatrapati Bisen, Ashwini Kedar, Karan Singh Yadav, Atul Krishna, Abdul Akhir, Sidharth Chopra, Madhav Nilakanth Mugale, Rabi Sankar Bhatta
Summary: The study developed a dual-loaded film for the treatment of polymicrobial keratitis, which exhibited excellent antimicrobial activity and corneal permeation. Compared to marketed formulations, the film showed improved ocular bioavailability and could be a viable alternative for PMK treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Saikat Pande, Janu Vashi, Ajay Solanki
Summary: This study investigated the potential of Eudragit coated chitosan microspheres in delivering Flurbiprofen in a sustained manner to the ileo-colonic region of the gastrointestinal tract for the treatment of ulcerative colitis. After optimization, the desired release profile was achieved, and the stability and molecular dispersion of the drug in the polymer matrix were confirmed.
CURRENT DRUG DELIVERY
(2022)
Article
Multidisciplinary Sciences
Caitlin A. Moe, Prajna Lalitha, N. Venkatesh Prajna, Jeena Mascarenhas, Muthiah Srinivasan, Manoranhan Das, Arun Panigrahi, Revathi Rajaraman, Gerami D. Seitzman, Catherine E. Oldenburg, Thomas M. Lietman, Jeremy D. Keenan
Summary: Acanthamoeba keratitis is more difficult to treat and has worse clinical outcomes compared to bacterial or fungal ulcers.
Review
Ophthalmology
Stephen Tuft, Tobi F. Somerville, Ji-Peng Olivia Li, Timothy Neal, Surjo De, Malcolm J. Horsburgh, Joanne L. Fothergill, Daniel Foulkes, Stephen Kaye
Summary: Bacterial keratitis is a common corneal infection that can lead to severe visual loss, but there are uncertainties surrounding its diagnosis criteria and bacterial resistance. Current treatment strategies and research are primarily based on systemic administration data, without sufficient consideration for local corneal concentrations and biological activity.
PROGRESS IN RETINAL AND EYE RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Natalia N. Porfiryeva, Irina I. Semina, Ilgiz A. Salakhov, Rouslan I. Moustafine, Vitaliy V. Khutoryanskiy
Summary: Nasal drug delivery systems based on cationic and anionic Eudragit copolymers were designed, resulting in nanoparticles with mucoadhesive or mucus-penetrating properties for delivering haloperidol to the brain. Analysis on sheep nasal mucosa and rats in vivo confirmed the effectiveness of these nanoparticles in drug delivery.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Victoria Diaz-Tome, Xurxo Garcia-Otero, Ruben Varela-Fernandez, Manuel Martin-Pastor, Andrea Conde-Penedo, Pablo Aguiar, Miguel Gonzalez-Barcia, Anxo Fernandez-Ferreiro, Francisco J. Otero-Espinar
Summary: The study developed two hydrogels to improve voriconazole's ophthalmic solubility, permanence, and safety. Voriconazole-cyclodextrin inclusion complexes significantly increased water solubility and both hydrogels showed good corneal permeability. In vivo ocular permanence study showed longer permanence time compared to the voriconazole control formulation, suggesting these formulations are a good alternative for the treatment of fungal keratitis.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Dibyalochan Mohanty, Sadaf Jamal Gilani, Ameeduzzafar Zafar, Syed Sarim Imam, Ladi Alik Kumar, Mohammed Muqtader Ahmed, Mohammed Asadullah Jahangir, Vasudha Bakshi, Wasim Ahmad, Eyman Mohamed Eltayib
Summary: The present study focuses on preparing polymeric ALG nanoparticles for diabetes management. The optimized ALG-NPs show small size, high encapsulation efficiency, prolonged release pattern, improved permeation, pharmacokinetic profile, and anti-diabetic activity compared to pure ALG.
Review
Chemistry, Multidisciplinary
Ridhdhi S. Dave, Taylor C. Goostrey, Maya Ziolkowska, Sofia Czerny-Holownia, Todd Hoare, Heather Sheardown
Summary: There is a growing demand for effective treatments for ocular conditions, with topical administration being the preferred method despite its drawbacks. Nanoparticles with tunable mucoadhesion and/or mucopenetration show potential to overcome these drawbacks and improve ocular bioavailability, reduce toxicity, and increase ocular retention. Recent advances in developing nanocarriers with tunable mucoadhesion and mucopenetration for drug delivery to the eye are highlighted in the current review.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Medicinal
Saniya Jawed, C. S. Satish
Summary: The study aims to develop a pulsatile and mucoadhesive drug delivery system for the time-regulated release of an ACE inhibitor Perindopril Erbumine to counteract early morning pathology like hypertension. Matrix tablets were prepared using Eudragit RSPO, Eudragit RLPO, and HPMC K15M. The optimized formulations P1T3 and P2T8 were coated for a lag time with compression coating of HPMC K4M and encapsulated in a Eudracap (TM) capsule to provide gastric resistance. The in-vitro release data showed a pause phase followed by a release of the drug to cope with the early morning rush in blood pressure, and a sustained release afterwards.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)