Review
Biochemistry & Molecular Biology
Maria Gagliardi, Ana Tari Ashizawa
Summary: ASOs are a novel and promising class of drugs used to selectively inhibit the translation of disease-associated genes. Challenges in ASO delivery and stability require strategic approaches to overcome these limitations for their full potential in precision medicine.
Review
Pharmacology & Pharmacy
Raghav Gupta, Sagar Salave, Dhwani Rana, Bharathi Karunakaran, Arun Butreddy, Derajram Benival, Nagavendra Kommineni
Summary: This review explores the potential role of liposomes as a drug delivery system for antisense oligonucleotides (ASOs), particularly in nucleic acid therapeutics. The potential benefits of liposomes as an ASO carrier, including their method of preparation, characterization, routes of administration, and stability, are thoroughly discussed. The major highlights of this review are the novel perspective on therapeutic applications of liposomal ASO delivery in various diseases, such as cancer, respiratory diseases, ophthalmic delivery, infectious diseases, gastrointestinal diseases, neuronal disorders, hematological malignancies, myotonic dystrophy, and neuronal disorders.
Article
Pharmacology & Pharmacy
Dan Wang, Xuelei Wang, Li Wang, Jin Zhang, Jie Ma, Guimin Xia, Bin Hong
Summary: miR185 inhibitor miR185i is a promising drug for reducing cholesterol levels; LipomiR185i is a nanoparticle drug carrier with high encapsulation efficiency and transfection activity; LipomiR185i can safely and effectively deliver miR185i to the liver, downregulate miR185 levels without significant tissue damage.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Jingjing Gan, Yuxiao Liu, Lingyu Sun, Wenjuan Ma, Guopu Chen, Cheng Zhao, Lihui Wen, Yuanjin Zhao, Lingyun Sun
Summary: This study presents a pH-sensitive drug delivery system for oral treatment of inflammatory bowel disease, which can significantly decrease the production of TNF-alpha in colitis animal models and alleviate colitis symptoms in mice after oral administration. The designed system shows promising potential in treating colon-associated diseases.
APPLIED MATERIALS TODAY
(2021)
Review
Polymer Science
Viktoria Hornok
Summary: This paper summarizes the research results on serum albumin-based nanoparticles for drug delivery purposes, focusing on their preparation techniques, synthesis parameters, and successful clinical applications. Despite promising possibilities, products made from different types of albumin nanoparticles, with the exception of a few, have not been invented yet. The paper also discusses promising applications of serum albumin nanoparticles for various biomedical purposes, such as carriers, delivery systems, and contrast agents.
Article
Chemistry, Multidisciplinary
Jovana Mitrovic, Gabriella Richey, Sarah Kim, Mustafa O. O. Guler
Summary: Peptides serve as versatile building blocks for the fabrication of various nanostructures, such as hydrogels and nanoparticles. Precise chemical functionalization allows for controlled bioactivity and physical properties, enabling the development of functional materials. The intermolecular interactions and intrinsic peptide characteristics are determined by the conjugation of small molecules on amino acid side chains. This Perspective discusses peptide building blocks, nanostructure formation mechanisms, and the properties of these peptide materials, providing insights from recent publications. Bioinstructive and stimuli-responsive peptide materials have significant impacts in the field of nanomedicine, including drug delivery, cellular engineering, regenerative medicine, and biomedicine.
Review
Pharmacology & Pharmacy
Woan-Yuh Tarn, Yun Cheng, Shih-Han Ko, Li-Min Huang
Summary: Nucleic acid-based therapeutics, particularly Antisense Oligonucleotides (ASOs), have shown effectiveness in treating genetic disorders, cancer, and viral infections. ASOs can be quickly developed to target newly emerging viruses and their variants, making them a promising tool in antiviral therapy.
Review
Oncology
Hiroaki Taniguchi, Yasunori Suzuki, Kohzoh Imai, Yasushi Adachi
Summary: Oligonucleotide therapeutics, including antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs), have great potential in targeting specific DNA or RNA sequences or proteins. However, their clinical application is still challenging and needs to be compatible with next-generation sequencing for diagnosis.
Article
Chemistry, Multidisciplinary
Mitsuru Naito, Hiroyuki Chaya, Kazuko Toh, Beob Soo Kim, Kotaro Hayashi, Shigeto Fukushima, Tetsuya Nagata, Takanori Yokota, Kazunori Kataoka, Kanjiro Miyata
Summary: The researchers found that chemical modification of oligonucleotides to have higher negative charges facilitated the formation of polyion pairs between the oligonucleotide and bPEG-PLys under harsh biological conditions, leading to enhanced blood circulation of uPICs.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Chemistry, Medicinal
Farrukh Zeeshan, Thiagarajan Madheswaran, Jithendra Panneerselvam, Rajeev Taliyan, Prashant Kesharwani
Summary: This article discusses the salient characteristics, design, and categories of albumin-based nanocarriers (ANCs) in the context of their application in cancer management. It also explores the fabrication methods, use in gene, cancer, and multimodal therapy, cancer diagnosis, and imaging of ANCs. Lastly, the article briefly covers the formulations, commercial products, and clinical testing of ANCs.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mimansa, Manu Jamwal, Reena Das, Asifkhan Shanavas
Summary: This study reports drug nanocrystals stabilized with host-specific serum proteins, providing high loading capacity. Human serum derived curcumin nanoparticles (Cur-NanoSera) demonstrated superior in vitro anticancer efficiency compared to free drugs and exhibited good hemocompatibility. The preadsorbed protein coating prevented further protein corona formation, even after repeated serum exposures. Acute and subacute toxicity evaluations in mice showed no prominent inflammatory response or organ damage. Passive accumulation of Cur-NanoSera in a breast tumor model significantly suppressed tumor growth and controlled splenomegaly associated with tumor burden.
Article
Pharmacology & Pharmacy
Tsuyoshi Yamamoto, Yahiro Mukai, Fumito Wada, Chisato Terada, Yukina Kayaba, Kaho Oh, Asako Yamayoshi, Satoshi Obika, Mariko Harada-Shiba
Summary: Development of clinically relevant anti-microRNA antisense oligonucleotides remains a major challenge. One promising configuration called tiny LNA, highly chemically modified with high activity and specificity, shows enhanced in vivo activity with the introduction of N-acetylgalactosamine (GalNAc). GalNAc improves pharmacokinetics, and the ligand should be introduced at the 5' terminus for optimal impact. This strategy may pave the way for clinical application of miRNA-targeting small ASO therapy.
Article
Pharmacology & Pharmacy
Nitjawan Sahatsapan, Boonnada Pamornpathomkul, Theerasak Rojanarata, Tanasait Ngawhirunpat, Raksawan Poonkhum, Praneet Opanasopit, Prasopchai Patrojanasophon
Summary: Chitosan-maleimide coated liposomes showed improved buccal delivery of protein, with strong mucoadhesive capability and high buccal permeation.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Claudia Bonechi, Fariba Fahmideh Mahdizadeh, Luigi Talarico, Simone Pepi, Gabriella Tamasi, Gemma Leone, Marco Consumi, Alessandro Donati, Agnese Magnani
Summary: Glaucoma, a group of neurodegenerative diseases, is the second leading cause of irreversible blindness worldwide. The limited penetration of drugs through the ocular barrier reduces the systemic bioavailability, leading to the need for frequent drug administration and potential toxic effects. Liposomes and other novel drug-delivery systems can enhance the therapeutic efficacy of antiglaucomatous drugs by improving drug penetration, bioavailability, sustained release, tissue targeting, and reduction in intraocular pressure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Wei-Hsiang Hsu, Chien-Liang Ku, You-Ren Lai, Steven S. -S. Wang, Shiu-Huey Chou, Ta-Hsien Lin
Summary: This study aimed to develop DOXO-coupled glycated BSA nanoparticles and improve their targeting capability towards GLUT5 transporters over-expressed on breast cancer cells. The synthesized nanoparticles had a spherical shape with a hydrodynamic diameter of approximately 60.74 nm and a zeta-potential of approximately -42.20 mV. Furthermore, the DOXO-coupled glycated BSA nanoparticles exhibited cytotoxicity towards both MCF-7 and MDA-MB-231 cells. Overall, this research demonstrates the potential of drug-coupled glycated BSA nanoparticles as a targeted drug delivery platform for breast cancer therapy. Rating: 9/10.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
