Review
Cell Biology
Maurizio Capuozzo, Francesco Ferrara, Mariachiara Santorsola, Andrea Zovi, Alessandro Ottaiano
Summary: This article reviews the role of circulating tumor cells (CTCs) in solid tumors, highlighting their importance in predicting clinical outcomes and guiding prognosis. The article also discusses the recent advancements and challenges in CTC detection methods, as well as the significance of integrating CTC-based liquid biopsies into clinical practice.
Article
Surgery
Leonie Konczalla, Tarik Ghadban, Katharina E. Effenberger, Anna Wostemeier, Sabine Riethdorf, Faik G. Uzunoglu, Jakob R. Izbicki, Klaus Pantel, Maximilian Bockhorn, Matthias Reeh
Summary: The study aimed to evaluate the prognostic significance of disseminated tumor cells (DTCs) and circulating tumor cells (CTCs) in esophageal cancer patients. Only CTCs were significantly associated with shorter overall and relapse-free survival, suggesting that CTC status could serve as an independent prognostic marker in early-stage EC patients.
Article
Endocrinology & Metabolism
Dalvinder Mandair, Mohid S. Khan, Andre Lopes, Luke Furtado O'Mahony, Leah Ensell, Helen Lowe, John A. Hartley, Christos Toumpanakis, Martyn Caplin, Tim Meyer
Summary: The study identified the optimal CTC thresholds of 1 and 2 for predicting survival and progression-free survival in metastatic PanNET and midgut NETs, respectively. These thresholds can assist in patient stratification and clinical trial design.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Young Hoon Choi, Tae Ho Hong, Seung Bae Yoon, In Seok Lee, Myung Ah Lee, Ho Joong Choi, Moon Hyung Choi, Eun Sun Jung
Summary: Portal venous circulating tumor cells (CTCs) can serve as a biomarker for early recurrence and poor prognosis in patients with resectable pancreatic cancer. The number of CTCs is associated with stage and regional lymph node metastasis, and low portal venous CTCs are associated with better overall and recurrence-free survival.
Review
Biochemistry & Molecular Biology
Teresa Magnes, Sandro Wagner, Dominik Kiem, Lukas Weiss, Gabriel Rinnerthaler, Richard Greil, Thomas Melchardt
Summary: Head and neck squamous cell carcinoma is a heterogeneous disease arising from the mucosa of the upper aerodigestive tract, with only about one third of patients responding to checkpoint inhibitors. HPV status and combined positive score are the main biomarkers used in clinical practice, while other factors like tumor mutational burden and immune microenvironment show promise but require validation in prospective trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Hongfang Zhao, Luxuan Wang, Chuan Fang, Chunhui Li, Lijian Zhang
Summary: Circulating tumor cells (CTCs) can serve as a predictive biomarker in breast cancer (BC), with potential for diagnostic and prognostic evaluation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Xuan Li, Hefen Sun, Qiqi Liu, Yang Liu, Yifeng Hou, Wei Jin
Summary: By analyzing single-cell RNA data of CTCs from breast cancer patients, 18 genes closely related to a specific CTC epithelial phenotype and patient prognosis were identified. The risk score composed of these genes showed good prognostic and predictive values in breast cancer patients, potentially serving as a personalized prognostic marker or therapy guide marker.
CANCER CELL INTERNATIONAL
(2021)
Article
Immunology
Yijun Xu, Zhaosheng Li, Huina Shi, Mingchen Zhu
Summary: This study analyzed the distribution of immune cell subpopulations in peripheral blood samples from pancreatic cancer patients and investigated their correlation with clinical parameters and prognosis. The study found that pancreatic cancer patients had a decreased proportion of lymphocytes and an increased CD4/CD8 ratio. Increased proportions of lymphocytes and NKT cells were observed more frequently in patients over 60 years and in patients with metastasis. Furthermore, post-operative pancreatic cancer patients had significantly reduced proportions of CD4(+)T cells, B cells, and CD4/CD8 ratio, while the frequency of CD8(+)T cells and NKT cells was significantly elevated. Kaplan-Meier analysis indicated that patients with high lymphocyte proportion had prolonged overall survival.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Oncology
Zuxi Li, Meijuan Song, Shangjun Han, Chuanwei Jin, Jing Yang
Summary: Circulating tumor cells (CTC) are associated with the prognosis of patients with gastric cancer. Gastric cancer patients with positive CTC may have a poorer prognosis compared to those with CTC-negative tumors. CTC-positive patients have more advanced TNM staging, poorer tumor differentiation, and earlier distant metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Kai Cui, Yang Ou, Dawei Ning, Hao Li, Yue Xi, Sheng Li
Summary: The study aimed to analyze the relationship between the number of circulating tumor cells (CTCs) and circulating tumor microemboli (CTM) in the peripheral blood of liver cancer patients, finding that AFP, number of CTCs, and presence of CTM were independent risk factors for survival in patients with liver cancer.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Oncology
Oddmund Nordgard, Morten Lapin, Kjersti Tjensvoll, Satu Oltedal, Karin Hestnes Edland, Nicolay Bore Neverdahl, Dmitrij Fostenes, Herish Garresori, Nils Glenjen, Rune Smaaland, Bjornar Gilje
Summary: This study found that the detection of disseminated tumor cells in the bone marrow of PDAC patients has significant prognostic value, especially when detecting keratins KRT7 and KRT8. These findings may help guide treatment strategies and prognosis evaluation for PDAC patients.
Article
Chemistry, Medicinal
Chaithanya Chelakkot, Hobin Yang, Young Kee Shin
Summary: Shedding cancer cells from the primary site or bone marrow into the circulatory system and their subsequent formation of secondary metastatic lesions is a key feature of invasive cancers. Circulating tumor cells (CTCs), found either as single cells or clusters, carry valuable information and have the potential to predict cancer prognosis, progression, and guide tailored therapies.
Article
Oncology
Eva Welsch, Eva Schuster, Michael Krainer, Maximilian Marhold, Rupert Bartsch, Michael B. Fischer, Michael Hermann, Gabriele Hastermann, Heidemarie Uher, Gerhard Sliutz, Birgit Anker, Robert Zeillinger, Eva Obermayr
Summary: Liquid biopsy is a promising tool for monitoring cancer therapy, but further research is needed to improve sensitivity, specificity, standardization, and cost-effectiveness. In this study, two panels of transcripts related to circulating tumor cells (CTCs) were evaluated in breast cancer patients. The positivity rates of these panels were higher in metastatic patients compared to early-stage patients. Certain individual markers within these panels correlated with shorter overall survival in the metastatic patients. The findings highlight the additional value of non-epithelial phenotype markers in Panel 2.
Article
Oncology
Retno Ningsi, Maha Elazezy, Luisa Stegat, Elena Laakmann, Sven Peine, Sabine Riethdorf, Volkmar Mueller, Klaus Pantel, Simon A. Joosse
Summary: CTCs have been found to be associated with metastasis and survival in breast cancer patients. Evaluating the expression of estrogen receptors (ER) in CTCs may help with personalized treatment. Some patients have both ER-positive and ER-negative CTCs at the time of metastasis, which may lead to resistance to hormonal therapy. Therefore, monitoring the status of CTC-ER in breast cancer patients can provide prognostic and predictive value.
Article
Multidisciplinary Sciences
Sara Valpione, Piyushkumar A. Mundra, Elena Galvani, Luca G. Campana, Paul Lorigan, Francesco De Rosa, Avinash Gupta, John Weightman, Sarah Mills, Nathalie Dhomen, Richard Marais
Summary: High baseline T cell receptor diversity is predictive of favorable prognosis in multiple cancer types, while monoclonal expansion of T cells pre-treatment correlates with good response to immune checkpoint blockade therapy in metastatic melanoma patients.
NATURE COMMUNICATIONS
(2021)