Review
Pharmacology & Pharmacy
Prashant Kesharwani, Rahul Chadar, Afsana Sheikh, Waleed Y. Rizg, Awaji Y. Safhi
Summary: Cluster of differentiation 44 (CD44) is a cell surface glycoprotein overexpressed in various solid tumors. It plays a significant role in cell proliferation, cell-to-cell interaction, cellular migration, inflammation, and immune responses. Nanocarriers have been developed to target the CD44 receptor and improve the efficacy of chemotherapy. Hyaluronic acid (HA) also plays a crucial role in cancer therapy and interacts with CD44, providing a potential approach for targeted therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Instruments & Instrumentation
Sobia Noreen, Jin-Xiang Ma, Muhammad Saeed, Fahad Pervaiz, Muhammad Farhan Hanif, Bilal Ahmed, Muhammad Irshad Farooq, Faizan Akram, Muhammad Safdar, Asadullah Madni, Muhammad Naveed, Li Chang-Xing
Summary: Natural biodegradable polymers play a vital role in transdermal drug delivery systems by controlling drug release rate. They have advantages of availability and affordability, allowing the development of regulated and targeted pharmaceutical delivery systems.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yerin Lee, Saebin Lim, Ji An Kim, Yoon Hong Chun, Hyun Jong Lee
Summary: This study develops a novel drug delivery system using a hyaluronic acid hydrogel for controlled release of epidermal growth factor to enhance skin wound healing. The system achieves sustained release of EGF by introducing an acrylate group to EGF and chemically bonding it to the hyaluronic acid hydrogel matrix. The system shows positive effects on cell proliferation and wound healing in a rat model.
Article
Pharmacology & Pharmacy
Ali Alsuraifi, Essyrose Mathew, Dimitrios A. Lamprou, Anthony Curtis, Clare Hoskins
Summary: This study successfully synthesized amphiphilic APMA monomers and copolymerized them with HPMA to form a thermoresponsive system for encapsulating and releasing model drugs. HPMAco-(APMA-Dansyl 2%) exhibited the highest drug encapsulation ability, while the incorporation of PEG resulted in faster drug release rates.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Vellingiri Yasothamani, Laxmanan Karthikeyan, Selvaraj Shyamsivappan, Yuvaraj Haldorai, Dayakar Seetha, Raju Vivek
Summary: TNBC patients currently lack approved targeted therapy, leading to high mortality rates. Developing a new nanotherapeutic approach of combinational therapy, such as HA-PANi/R837 nanoparticles, shows promise in improving treatment outcomes.
Review
Pharmacology & Pharmacy
Eva Sanchez Armengol, Flavia Laffleur
Summary: The introduction of mucoadhesion and mucoadhesive polymers in the 20th century provided several advantages, such as enhanced drug absorption and extended residence at specific sites. Chemical modification with sulfhydryl groups on polymeric excipients improved mucoadhesive features. However, the first generation of thiomers had drawbacks, leading to the development of second and third generation polymers to address these issues.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Hai-Yan Wang, Yan Zhang, Xing-Hui Ren, Xi-Wen He, Wen-You Li, Yu-Kui Zhang
Summary: In this study, a biocompatible, tumor-targeted nanoplatform (HIDSi(Gd)NPs@PDA-HA) based on HMONs was developed for accurate tumor-targeting and synergistic therapy. The nano-carrier promoted endocytosis in cancer cells, released DOX in response to tumor microenvironment, and utilized ICG for photothermal therapy, achieving multi-mode imaging-guided therapy. The results in tumor-bearing mice demonstrated excellent therapeutic efficacy, indicating the potential of this multifunctional nanomaterial for precise diagnosis and efficient treatment.
Review
Chemistry, Multidisciplinary
Alina Kirillova, Taylor R. Yeazel, Darya Asheghali, Shannon R. Petersen, Sophia Dort, Ken Gall, Matthew L. Becker
Summary: The goal of this review is to provide a guide for the fabrication of biodegradable polymer-based scaffolds that includes the complete pathway starting from selecting materials, choosing the correct fabrication method, and considering the requirements for tissue specific applications of the scaffold.
Review
Pharmacology & Pharmacy
Mengru Yang, Ying Zhang, Zheming Hu, Haonan Xie, Wenli Tian, Zhidong Liu
Summary: This article summarizes the application of hyaluronic acid-based nanoparticles in combination therapy for cancer treatment. These nanoparticles have exceptional biocompatibility and targeting capabilities, offering a new approach for precise drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Natallia V. Dubashynskaya, Anton N. Bokatyi, Ekaterina R. Gasilova, Anatoliy V. Dobrodumov, Yaroslav A. Dubrovskii, Elena S. Knyazeva, Yuliya A. Nashchekina, Elena V. Demyanova, Yury A. Skorik
Summary: The development of nanotechnology-based antibiotic delivery systems is crucial for combating microbial multidrug resistance. This study successfully synthesized conjugates of colistin and hyaluronic acid, which showed improved biopharmaceutical characteristics and reduced cytotoxicity. These conjugates have great potential for the development of safe and effective nanodrugs for antimicrobial therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Teresa Silvestri, Barbara Immirzi, Giovanni Dal Poggetto, Paola Di Donato, Valentina Mollo, Laura Mayol, Marco Biondi
Summary: Polymeric microparticles (MPs) designed for intravitreal administration of therapeutic proteins can prolong the half-life of proteins in the vitreous and delay adverse effects. Addition of poloxamers resulted in a more compact MP matrix, leading to reduced initial release of proteins.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, Research & Experimental
Xiang Sun, Rui Zhao, Eryong Zhao, Qing Wang, Wenqin Lian, Jian Xiong
Summary: A novel polymeric PTX formulation was developed for targeted therapy of ovarian cancer cells through prodrug engineering and HA decoration strategies. The HA-coated nanodrugs showed preferential accumulation in CD44-expressing cells, inducing enhanced cytotoxicity, reduced cell proliferation, and increased cell apoptosis. In vivo study demonstrated the potential feasibility of HA-PLA-PTX NPs as an effective delivery system for ovarian cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biophysics
Marek Brzezinski, Marta Socka, Tomasz Makowski, Bartlomiej Kost, Marcin Cieslak, Karolina Krolewska-Golinska
Summary: This study developed a novel microfluidic approach for preparing (co)polymeric and hybrid nanoparticles, which showed great potential in drug release and inhibition of breast cancer cells. The composition of PCL/TA NPs demonstrated the most efficient antitumor activity among all formulations, surpassing the efficacy of free DOX.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Engineering, Biomedical
Meirong Li, Zheng-Ian Lin, Jingyu Yang, Haoqiang Huang, Guan-Lin Liu, Qiqi Liu, Xinmeng Zhang, Ying Zhang, Zhourui Xu, Haoming Lin, Yujuan Chai, Xin Chen, Bao-Tsan Ko, Jia Liu, Chih-Kuang Chen, Chengbin Yang
Summary: Osteosarcoma is a highly invasive and deadly cancer that often occurs in children and adolescents. The overexpression of PLK1 gene in tumors promotes cancer cell proliferation and transformation, making it a therapeutic target for osteosarcoma. However, current RNA interference-based therapies lack a safe and efficient nonviral gene vector. In this study, biodegradable and CO2-derivative cationic poly(vinylcyclohexene carbonates) (CPCHCs) were used as gene vectors for siPLK1 therapeutic strategy in osteosarcoma treatment. Among them, CPCHC60 showed excellent performance in gene transfection efficiency, endo-lysosome escaping, biodegradability, and biosafety. The treatment with CPCHCs/siRNA nanoparticles significantly down-regulated the expression level of PLK1 gene in osteosarcoma cells, leading to cell arrest and apoptosis, resulting in significant tumor regression both in vitro and in vivo. This study provides new insights into the development of superior nonviral gene vectors for cancer treatment and holds high potential for translational nanomedicine applications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Yuvaraj Arun, Radhakanta Ghosh, Abraham J. Domb
Summary: Biodegradable, hydrophobic, and injectable liquid polymers are able to achieve sustained, local drug release, with potential applications in regenerative medicine.
ADVANCED FUNCTIONAL MATERIALS
(2021)