Increased Methylation of the MOR Gene Proximal Promoter in Primary Sensory Neurons Plays a Crucial Role in the Decreased Analgesic Effect of Opioids in Neuropathic Pain

Chronic opioid use is associated with increased DNA methylation correlating with increased clinical pain

(2012) Alexandra Doehring et al.   PAIN

Intrathecal 5-azacytidine inhibits global DNA methylation and methyl- CpG-binding protein 2 expression and alleviates neuropathic pain in rats following chronic constriction injury

(2011) Ying Wang et al.   BRAIN RESEARCH

Dynamic temporal and spatial regulation of mu opioid receptor expression in primary afferent neurons following spinal nerve injury

(2011) Chun-Yi Leel et al.   EUROPEAN JOURNAL OF PAIN

Chronic High-Fat Diet Drives Postnatal Epigenetic Regulation of μ-Opioid Receptor in the Brain

(2011) Zivjena Vucetic et al.   NEUROPSYCHOPHARMACOLOGY

Maternal High-Fat Diet Alters Methylation and Gene Expression of Dopamine and Opioid-Related Genes

(2010) Zivjena Vucetic et al.   ENDOCRINOLOGY

Epigenetic Gene Silencing Underlies C-Fiber Dysfunctions in Neuropathic Pain

(2010) H. Uchida et al.   JOURNAL OF NEUROSCIENCE

Morphine versus Mexiletine for Treatment of Postamputation Pain

(2009) Christopher L. Wu et al.   ANESTHESIOLOGY

Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain

(2009) Ilona Obara et al.   PAIN

Neuropathic Pain

(2009) Alec B. OʼConnor   PHARMACOECONOMICS

Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders

(2008) T ABEL et al.   CURRENT OPINION IN PHARMACOLOGY

Epigenetic programming of μ-opioid receptor gene in mouse brain is regulated by MeCP2 and brg1 chromatin remodelling factor

(2008) Cheol Kyu Hwang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Spinal  -Opioid Receptor-Expressing Dorsal Horn Neurons: Role in Nociception and Morphine Antinociception

(2008) R. H. Kline et al.   JOURNAL OF NEUROSCIENCE

Increased OPRM1 DNA Methylation in Lymphocytes of Methadone-Maintained Former Heroin Addicts

(2008) David A Nielsen et al.   NEUROPSYCHOPHARMACOLOGY