Cyclic Phosphatidic Acid Relieves Osteoarthritis Symptoms

High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis

(2014) Misato Hashizume et al.   Modern Rheumatology

Osteoarthritis year 2012 in review: clinical

(2012) M.C. Hochberg   OSTEOARTHRITIS AND CARTILAGE

Protection of Neuroblastoma Neuro2A Cells from Hypoxia-Induced Apoptosis by Cyclic Phosphatidic Acid (cPA)

(2012) Mari Gotoh et al.   PLoS One

Synthesis of enantiopure 2-carba-cyclic phosphatidic acid and effects of its chirality on biological functions

(2011) Emi Nozaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Antinociceptive Effect of Cyclic Phosphatidic Acid and Its Derivative on Animal Models of Acute and Chronic Pain

(2011) Yasutaka Kakiuchi et al.   Molecular Pain

Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis

(2011) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

Effects of cyclic phosphatidic acid on delayed neuronal death following transient ischemia in rat hippocampal CA1

(2010) Mari Gotoh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pharmacologic therapy for osteoarthritis—the era of disease modification

(2010) David J. Hunter   Nature Reviews Rheumatology

Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections

(2008) R Dieguez-Gonzalez et al.   ANNALS OF THE RHEUMATIC DISEASES

Cyclic phosphatidic acid — A unique bioactive phospholipid

(2008) Y FUJIWARA   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese

(2008) Hideyuki Mototani et al.   HUMAN MOLECULAR GENETICS