Genetic Inactivation and Pharmacological Blockade of Sigma-1 Receptors Prevent Paclitaxel-Induced Sensory-Nerve Mitochondrial Abnormalities and Neuropathic Pain in Mice

σ1 Receptors Are Involved in the Visceral Pain Induced by Intracolonic Administration of Capsaicin in Mice

(2013) Rafael González-Cano et al.   ANESTHESIOLOGY

Effects of repeated milnacipran and fluvoxamine treatment on mechanical allodynia in a mouse paclitaxel-induced neuropathic pain model

(2013) Soh KATSUYAMA et al.   BIOMEDICAL RESEARCH-TOKYO

Sigma 1 receptor: A new therapeutic target for pain

(2013) Daniel Zamanillo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Induction of Monocyte Chemoattractant Protein-1 (MCP-1) and Its Receptor CCR2 in Primary Sensory Neurons Contributes to Paclitaxel-Induced Peripheral Neuropathy

(2013) Haijun Zhang et al.   JOURNAL OF PAIN

Sigma-1 Receptor Expression in Sensory Neurons and the Effect of Painful Peripheral Nerve Injury

(2013) Madhavi L Bangaru et al.   Molecular Pain

Potentiation of morphine-induced mechanical antinociception by σ1 receptor inhibition: Role of peripheral σ1 receptors

(2013) Cristina Sánchez-Fernández et al.   NEUROPHARMACOLOGY

Paclitaxel-induced neuropathic pain is age dependent and devolves on glial response

(2012) J. Ruiz-Medina et al.   EUROPEAN JOURNAL OF PAIN

Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy

(2012) H. Zheng et al.   EXPERIMENTAL NEUROLOGY

Role of Sigma-1 Receptors in Paclitaxel-Induced Neuropathic Pain in Mice

(2012) Francisco Rafael Nieto et al.   JOURNAL OF PAIN

Evidence That Spinal Astrocytes but Not Microglia Contribute to the Pathogenesis of Paclitaxel-Induced Painful Neuropathy

(2012) Haijun Zhang et al.   JOURNAL OF PAIN

Functional deficits in peripheral nerve mitochondria in rats with paclitaxel- and oxaliplatin-evoked painful peripheral neuropathy

(2011) Huaien Zheng et al.   EXPERIMENTAL NEUROLOGY

The Dipeptide Phe-Phe Amide Attenuates Signs of Hyperalgesia, Allodynia and Nociception in Diabetic Mice Using a Mechanism Involving the Sigma Receptor System

(2011) Masahiro Ohsawa et al.   Molecular Pain

The response of spinal microglia to chemotherapy-evoked painful peripheral neuropathies is distinct from that evoked by traumatic nerve injuries

(2011) F.Y. Zheng et al.   NEUROSCIENCE

Mitochondrial abnormality in sensory, but not motor, axons in paclitaxel-evoked painful peripheral neuropathy in the rat

(2011) W.H. Xiao et al.   NEUROSCIENCE

Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats

(2011) K. Okubo et al.   NEUROSCIENCE

Characterization of oxaliplatin-induced chronic painful peripheral neuropathy in the rat and comparison with the neuropathy induced by paclitaxel

(2011) W.H. Xiao et al.   NEUROSCIENCE

Involvement of Mitochondrial Permeability Transition Pore Opening in 7-Xylosyl-10-Deacetylpaclitaxel-Induced Apoptosis

(2011) Shougang Jiang et al.   PLANTA MEDICA

Neurophysiological and neuropathological characterization of new murine models of chemotherapy-induced chronic peripheral neuropathies

(2010) V.A. Carozzi et al.   EXPERIMENTAL NEUROLOGY

The sigma-1 receptor chaperone as an inter-organelle signaling modulator

(2010) Tsung-Ping Su et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Paclitaxel Directly Binds to Bcl-2 and Functionally Mimics Activity of Nur77

(2009) C. Ferlini et al.   CANCER RESEARCH

Abnormal calcium homeostasis in peripheral neuropathies

(2009) Paul Fernyhough et al.   CELL CALCIUM

Pharmacology and Therapeutic Potential of Sigma1 Receptor Ligands

(2009) E. Cobos et al.   Current Neuropharmacology

What is the mitochondrial permeability transition pore?

(2009) Andrew P. Halestrap   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sigma-1 Receptors Regulate Bcl-2 Expression by Reactive Oxygen Species-Dependent Transcriptional Regulation of Nuclear Factor  B

(2009) J. Meunier et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Olesoxime (cholest-4-en-3-one, oxime): Analgesic and neuroprotective effects in a rat model of painful peripheral neuropathy produced by the chemotherapeutic agent, paclitaxel

(2009) Wen Hua Xiao et al.   PAIN

Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury

(2009) Beatriz de la Puente et al.   PAIN

Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: Studies with selective sigma-1 ligands and sigma-1 knockout mice

(2009) José Manuel Entrena et al.   PAIN

Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors

(2009) José M. Entrena et al.   PSYCHOPHARMACOLOGY

Intrathecal Injection of the ς1 Receptor Antagonist BD1047 Blocks Both Mechanical Allodynia and Increases in Spinal NR1 Expression during the Induction Phase of Rodent Neuropathic Pain

(2008) Dae-Hyun Roh et al.   ANESTHESIOLOGY

Peripheral nerve damage associated with administration of taxanes in patients with cancer

(2008) Andreas A. Argyriou et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-l-carnitine: Effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells

(2007) Hai Wei Jin et al.   EXPERIMENTAL NEUROLOGY

Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice

(2007) Francisco Rafael Nieto et al.   PAIN

Experimental Studies of Potential Analgesics for the Treatment of Chemotherapy-Evoked Painful Peripheral Neuropathies

(2007) Wenhua Xiao et al.   PAIN MEDICINE

Intrathecal treatment with σ1 receptor antagonists reduces formalin-induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice

(2006) Hyun-Woo Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY