Article
Multidisciplinary Sciences
Sara Volpes, Ilenia Cruciata, Federica Ceraulo, Chiara Schimmenti, Flores Naselli, Cecilia Pinna, Maurizio Mauro, Pasquale Picone, Sabrina Dallavalle, Domenico Nuzzo, Andrea Pinto, Fabio Caradonna
Summary: The aim of this study was to evaluate the biological effects of natural stilbenoids found in Vitis vinifera, with a focus on their activity as epigenetic modulators. Resveratrol, pterostilbene, and (+/-)-trans-pterostilbene dehydrodimer showed no toxic effects and were effective in reversing arsenic damage in Caco-2 cell lines. Further studies are needed to clarify the mode of action of (+/-)-trans-delta-viniferin.
SCIENTIFIC REPORTS
(2023)
Review
Agriculture, Multidisciplinary
Yen-Chun Koh, Chi-Tang Ho, Min-Hsiung Pan
Summary: Biological targeting is a key strategy in drug development, but single-target drug binding may lead to failure due to the multifactorial nature of disease pathogenesis. Naturally derived drugs have multitarget effects in disease prevention or therapeutic actions without off-target effects.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Chiara Platella, Stefania Mazzini, Ettore Napolitano, Luce M. Mattio, Giovanni Luca Beretta, Nadia Zaffaroni, Andrea Pinto, Daniela Montesarchio, Sabrina Dallavalle
Summary: The natural compound stilbenoids, including (+/-)-trans-delta-viniferin, have shown the ability to bind to both DNA duplex and G-quadruplex structures, with higher affinity for the DNA targets compared to their monomeric counterparts. These compounds exhibit cytotoxicity and DNA damaging activity on cancer cell lines.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Food Science & Technology
Maria del Mar Contreras, Anouar Feriani, Irene Gomez-Cruz, Najla Hfaiedh, Abdel Halim Harrath, Inmaculada Romero, Eulogio Castro, Nizar Tlili
Summary: A grapevine shoot extract (GSE) containing stilbenoids, particularly trans-resveratrol and trans-epsilon-viniferin, was obtained using ultrasound-assisted extraction. GSE administration to a myocardial injury animal model showed improved plasma lipid profile, reduced plasma ion concentration disturbance, cardiac dysfunction, DNA damage, and necrosis of myocardial tissue. These effects are likely due to the antioxidant properties of GSE, increased levels of endogenous antioxidants, and decreased lipid peroxidation markers in the heart. The study also demonstrated ACE-inhibitory activity, indicating the potential of GSE in cardiovascular disease prevention. Our findings suggest that GSE, containing trans-resveratrol and its derivatives, has the potential to be used in the development of innovative functional ingredients.
Article
Pharmacology & Pharmacy
Katharina Held, Vincenzo Davide Aloi, Ana Cristina Nogueira Freitas, Annelies Janssens, Andrei Segal, Julia Przibilla, Stephan Ernst Philipp, Yu Tian Wang, Thomas Voets, Joris Vriens
Summary: This study compares the pharmacological properties of different splice variants of TRPM3, demonstrating that the length of the pore-forming loop in the alternative splicing region defines the channel's activation by specific compounds.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vincenzo Vestuto, Veronica Di Sarno, Simona Musella, Giorgio Di Dona, Ornella Moltedo, Isabel Maria Gomez-Monterrey, Alessia Bertamino, Carmine Ostacolo, Pietro Campiglia, Tania Ciaglia
Summary: The endoplasmic reticulum (ER) has various functions including calcium storage, protein synthesis, and lipid metabolism. ER stress, caused by disturbances in ER homeostasis, triggers unfolded protein response (UPR) to counteract the stress. Calcium levels are crucial in maintaining ER homeostasis and regulating cell fate, and dysregulation of calcium signaling is associated with diseases like neurodegeneration, cancer, and metabolic disorders. Recent research suggests that TRP channels play a role in UPR-mediated ER stress and can influence cell survival or death, making them a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Asia Fernandez-Carvajal, Gregorio Fernandez-Ballester, Antonio Ferrer-Montiel
Summary: Chronic pain and pruritus lack appropriate therapeutic intervention. TRPV1 is identified as a central channel in the pain and itch pathway, making it a valuable therapeutic target for these conditions.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Etienne de Coulon, Christian Dellenbach, Stephan Rohr
Summary: The LSSE system allows for comprehensive intracellular electrical recordings on cells undergoing strain events, providing stable conditions for studying mechanically activated ion currents. This system offers advanced insights into mechanosensitive ion channel function and allows for quantitative comparisons among different types of channels and cells.
Review
Biochemistry & Molecular Biology
Christophe Simard, Margaux Aize, Sebastien Chaigne, Harlyne Mpweme Bangando, Romain Guinamard
Summary: The role of ion channels in cardiac activity, morphological remodeling, and valve development and remodeling is discussed. Mutation in ion channel genes is observed in patients with malformation, such as bicuspid aortic valve. Ion channels are also involved in the morphological remodeling of valves, leading to aortic stenosis. Understanding the role of ion channels in the progression of aortic stenosis is crucial for developing new therapeutic approaches to avoid valve replacement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Milena Duitama, Yurany Moreno, Sandra Paola Santander, Zulma Casas, Jhon Jairo Sutachan, Yolima P. Torres, Sonia L. Albarracin
Summary: Transient receptor potential (TRP) channels play a critical role in cancer-related pain. Substances released by the cancer microenvironment modulate the activity of TRP channels, affecting pain transmission. Secondary metabolites derived from plant extracts have the potential to serve as therapeutic agents for relieving cancer-induced pain.
Article
Pharmacology & Pharmacy
Charlotte Van den Eynde, Katharina Held, Martina Ciprietti, Katrien De Clercq, Sara Kerselaers, Arnaud Marchand, Patrick Chaltin, Thomas Voets, Joris Vriens
Summary: This study identified loratadine, astemizole, and clemizole as antihistaminic drugs that can inhibit the activity of TRPV2, providing a starting point for the synthesis of more potent and selective TRPV2 antagonists.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Nadia Zaffaroni, Giovanni L. Beretta
Summary: Prostate cancer is the fifth leading cause of tumor-related deaths in men globally, with its long latency period making it ideal for chemopreventive studies. Resveratrol, a natural compound, has shown promise as a chemopreventive agent and enhancer of antitumor activity in prostate cancer. Ongoing clinical trials are exploring the potential of resveratrol as an antimetastatic agent in prostate cancer treatment.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Cell Biology
Goncalo Mesquita, Natalia Prevarskaya, Albrecht Schwab, V'yacheslav Lehen'kyi
Summary: TRP channels, a diverse superfamily of ion channels, have been implicated in various physiological processes and their potential role in cancer progression, particularly in pancreatic cancer, is being explored. This review analyzes existing knowledge on TRP channels in cancer, with a focus on potential therapeutic interventions for pancreatic ductal adenocarcinoma.
Review
Biochemistry & Molecular Biology
Charlotte Van den Eynde, Joris Vriens, Katrien De Clercq
Summary: Calcium ions play a critical role in cell function, with transient receptor potential (TRP) channels serving as a type of ion channel that can convey various stimuli and potentially participate in cellular responses to changing environments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Review
Respiratory System
Rebecca J. J. Stinson, Alyn H. H. Morice, Laura R. R. Sadofsky
Summary: Upper respiratory tract infections (URTIs) have a significant impact on society and there is no single effective treatment. This systematic review focuses on the role of plant derived substances in OTC remedies used to treat cold symptoms, with a particular focus on TRP channels involved in pain and cough.
RESPIRATORY RESEARCH
(2023)