Journal
MOLECULAR ORAL MICROBIOLOGY
Volume 30, Issue 3, Pages 186-197Publisher
WILEY
DOI: 10.1111/omi.12088
Keywords
membrane biogenesis; protein secretion; signal recognition particle; targeting; translocation; transport
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Funding
- NIH (NIDCR) [R01 DE008007, 1T90DE021990]
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Insights into the membrane biogenesis of oral and throat bacteria have highlighted key differences in protein localization by the general secretion pathway compared with the well-studied Escherichia coli model system. These intriguing novelties have advanced our understanding of both how these microorganisms have adapted to survive and cause disease in the oral cavity, and the field of protein translocation as a whole. This review focuses on findings that highlight where oral bacteria differ from the E.coli paradigm, why these differences are biologically important, and what questions remain about the differences in pathway function. The majority of insight into protein translocation in microbes of the oral cavity has come from streptococcal species, which will be the main topic of this review. However, other bacteria will be discussed when relevant. An overview of the E.coli model of protein targeting and translocation is provided for comparison.
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