Review
Oncology
Albrecht Stenzinger, Arndt Vogel, Ulrich Lehmann, Angela Lamarca, Paul Hofman, Luigi Terracciano, Nicola Normanno
Summary: Cholangiocarcinomas are a heterogeneous group of tumors with distinct genomic alterations. Next-generation sequencing is a powerful tool for identifying gene variants and guiding personalized treatment for patients with cholangiocarcinomas. Understanding the use of NGS in molecular profiling is crucial for healthcare professionals to optimize treatment outcomes.
CANCER TREATMENT REVIEWS
(2024)
Article
Pathology
Katherine A. Lau, Anders Goncalves da Silva, Torsten Theis, Joanna Gray, Susan A. Ballard, William D. Rawlinson
Summary: The widespread adoption of whole genome sequencing (WGS) data for pathogen surveillance and infectious disease decision-making requires ensuring data quality standards are met for accurate identification and monitoring of pathogens. The development of a pilot proficiency testing program helps establish baseline guidelines for standardization of WGS data and facilitates accreditation of test processes through ongoing performance benchmarking.
Article
Genetics & Heredity
Pramath Kakodkar, Yayuan Zhao, Henry Pan, Fang Wu, Twyla Pearce, Destinie Webster, Mohamed Elemary, Waleed Sabry, Luvinia Kwan, Lindsay Pelzer, Mark Bosch, Karen R. Sherwood, James Lan, Jenny Tran, Robert Liwski, Paul Keown, Ahmed Mostafa
Summary: This study validated a next-generation sequencing (NGS)-based chimerism assay for monitoring engraftment in allo-HSCT patients. The inclusion of specific cell subsets (CD3 and CD66) significantly improved the sensitivity and accuracy of engraftment monitoring. The implementation of NGS-based chimerism testing has the potential to streamline high-volume transplant services and improve clinical outcomes through early relapse detection and timely interventions.
FRONTIERS IN GENETICS
(2023)
Article
Hematology
Come Bommier, Claire Mauduit, Juliette Fontaine, Estelle Bourbon, Pierre Sujobert, Sarah Huet, Lucile Baseggio, Sandrine Hayette, Camille Laurent, Emmanuel Bachy, Herve Ghesquieres, Catherine Thieblemont, Gilles Salles, Alexandra Traverse-Glehen
Summary: The study showed that TNGS can lead to a more accurate diagnosis in challenging lymphoma cases, thus improving clinical management in routine practice.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Medical Laboratory Technology
Larissa V. Furtado, Rhona J. Souers, Patricia Vasalos, Jaimie G. Halley, Dara L. Aisner, Rakesh Nagarajan, Karl V. Voelkerding, Jason D. Merker, Eric Q. Konnick
Summary: The College of American Pathologists (CAP) launched a NGS bioinformatics proficiency testing survey in 2016 to evaluate clinical laboratory bioinformatics pipelines for oncology-associated variant detection. The study analyzed responses from 78 laboratories participating in the CAP NGS bioinformatics surveys between 2016 and 2019. The results showed high analytical sensitivity and specificity, supporting the use of in silico mutagenized NGS data sets for CAP surveys.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Article
Oncology
Severin Rodler, Andreas Jung, Philipp A. Greif, Katharina Ruehlmann, Maria Apfelbeck, Alexander Tamalunas, Alexander Kretschmer, Gerald B. Schulz, Bernadett Szabados, Christian Stief, Volker Heinemann, Christoph B. Westphalen, Jozefina Casuscelli
Summary: The aim of the study was to assess the feasibility and impact of routine NGS in personalized medicine for patients with genitourinary cancers. The results showed that NGS is increasingly feasible in clinical routine, with a growing number of tests performed and a decreasing turnaround time for therapy recommendations. However, challenges remain in terms of limited access to target agents for precision uro-oncology implementation.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Medical Laboratory Technology
Guigao Lin, Kuo Zhang, Jinming Li
Summary: The HLA-NGS proficiency testing scheme highlighted the importance of regular participation in external quality assessment for clinical laboratories performing HLA-NGS typing, in order to ensure accurate and reliable typing results.
CLINICA CHIMICA ACTA
(2022)
Article
Oncology
Caterina De Luca, Francesco Pepe, Antonino Iaccarino, Pasquale Pisapia, Luisella Righi, Angela Listi, Lorenza Greco, Gianluca Gragnano, Severo Campione, Gianfranco De Dominicis, Fabio Pagni, Roberta Sgariglia, Mariantonia Nacchio, Rossella Tufano, Floriana Conticelli, Elena Vigliar, Claudio Bellevicine, Diego Luigi Cortinovis, Silvia Novello, Miguel Angel Molina-Vila, Rafael Rosell, Giancarlo Troncone, Umberto Malapelle
Summary: Gene fusions are important predictive biomarkers for advanced NSCLC patients. A narrow NGS gene panel was developed and validated to cover relevant gene fusions and splicing events, demonstrating high efficiency in detecting these events in routine clinical samples.
Article
Medical Laboratory Technology
Bing M. Zhang, Alissa Keegan, Peng Li, Neal I. Lindeman, Rakesh Nagarajan, Mark J. Routbort, Patricia Vasalos, Annette S. Kim, Jason D. Merker
Summary: This study describes the characteristics of clinical NGS-based testing for detecting somatic variants in hematologic malignancies. The majority of laboratories use tumor-only targeted sequencing, with most testing performed on fresh bone marrow and peripheral blood samples. The data from this study can be useful for informing laboratory practices, quality management systems, regulations, and precision medicine efforts.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Virology
Se-Hee An, Gyeong-Beom Heo, Yong-Myung Kang, Mingeun Sagong, Na-Yeong Kim, Youn-Jeong Lee, Kwang-Nyeong Lee
Summary: Molecular diagnostic methods such as real-time RT-PCR are widely used for early detection of avian influenza virus. The Animal and Plant Quarantine Agency of Korea conducted five rounds of proficiency testing for rRT-PCR in local veterinary service laboratories involved in the AIV national surveillance program. The results showed improvement in performance and increased consistency over time.
Article
Pathology
Katherine Latham, Fei Dong
Summary: This study aimed to investigate the relationship between pathologic diagnosis and the success rate of cancer next-generation sequencing testing. The results showed that the success rate varied among different tumor types, with ovarian carcinomas having the highest success rate and pancreatic adenocarcinomas having the lowest. Understanding the factors that influence the success rate can help optimize tissue acquisition and usage for patient care.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Oncology
Sebastian Mondaca, Emily S. Lebow, Azadeh Namakydoust, Pedram Razavi, Jorge S. Reis-Filho, Ronglai Shen, Michael Offin, Hai-Yan Tu, Yonina Murciano-Goroff, Chongrui Xu, Alex Makhnin, Andres Martinez, Nick Pavlakis, Stephen Clarke, Malinda Itchins, Adrian Lee, Andreas Rimner, Daniel Gomez, Gaetano Rocco, Jamie E. Chaft, Gregory J. Riely, Charles M. Rudin, David R. Jones, Mark Li, Tristan Shaffer, Seyed Ali Hosseini, Caterina Bertucci, Lee P. Lim, Alexander Drilon, Michael F. Berger, Ryma Benayed, Maria E. Arcila, James M. Isbell, Bob T. Li
Summary: Liquid biopsy for plasma ctDNA NGS is effective in detecting ALK fusions with shorter turnaround time compared to tissue testing and high concordance rate. ctDNA can also match patients to ALK-directed therapy and detect mechanisms of treatment resistance.
Article
Biochemical Research Methods
Timo Lassmann
Summary: SAMStat is an efficient program for extracting quality control metrics from fastq and SAM/BAM files. It displays sequence composition, base quality composition, and mapping error profiles based on mapping quality, allowing users to quickly identify reasons for poor mapping. A major update to SAMStat now supports paired-end and long-read data, with quality control plots drawn using the ploty javascript library.
Article
Infectious Diseases
Jiaxin Bi, Zhixin Li, Xiao Lin, Fang Li, Hua Xu, Xuewen Yu, Lingyun Liu, Yingying Liang, Zhouwen Xu, Jiachuan Wang, Mumin Shao
Summary: This study aimed to investigate the etiology of granulomatous lobular mastitis (GLM) and found that Corynebacterium kroppenstedtii is the main pathogenic factor. Other unusual pathogens such as Pseudomonas oleovorans, human gammaherpesvirus 4, Acinetobacter baumannii, and Tepidiphilus thermophilus are also closely related to GLM. Abnormal sex hormone levels and autoimmune function are common causes, and treatment with lipophilic antibiotics (rifampicin) and prolactin inhibitors may be effective.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Pharmacology & Pharmacy
Alireza Tafazoli, Henk-Jan Guchelaar, Wojciech Miltyk, Adam J. Kretowski, Jesse J. Swen
Summary: Pharmacogenomics (PGx) utilizes genetic data to optimize drug therapy, with next-generation sequencing (NGS) emerging as a more comprehensive and cost-effective approach. The advantages and challenges of implementing NGS-based tests in PGx are discussed, along with solutions for managing these technologies in clinical practice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
L. S. Hiemcke-Jiwa, M. T. Meister, E. Martin, M. P. Dierselhuis, L. M. Haveman, R. W. J. Meijers, B. B. J. Tops, P. Wesseling, P. J. van Diest, J. M. van Gorp, J. Y. Hehir-Kwa, I. A. E. M. van Belzen, J. J. Bonenkamp, M. M. van Noesel, U. Flucke, L. A. Kester
ACTA NEUROPATHOLOGICA
(2023)
Article
Clinical Neurology
Michaela-Kristina Keck, Martin Sill, Andrea Wittmann, Piyush Joshi, Damian Stichel, Pengbo Beck, Konstantin Okonechnikow, Philipp Sievers, Annika K. Wefers, Federico Roncaroli, Shivaram Avula, Martin G. McCabe, James T. Hayden, Pieter Wesseling, Ingrid Ora, Monica Nister, Mariette E. G. Kranendonk, Bastiaan B. J. Tops, Michal Zapotocky, Josef Zamecnik, Alexandre Vasiljevic, Tanguy Fenouil, David Meyronet, Katja von Hoff, Ulrich Schuller, Hugues Loiseau, Dominique Figarella-Branger, Christof M. Kramm, Dominik Sturm, David Scheie, Tuomas Rauramaa, Jouni Pesola, Johannes Gojo, Christine Haberler, Sebastian Brandner, Tom Jacques, Alexandra Sexton Oates, Richard Saffery, Ewa Koscielniak, Suzanne J. Baker, Stephen Yip, Matija Snuderl, Nasir Ud Din, David Samuel, Kathrin Schramm, Mirjam Blattner-Johnson, Florian Selt, Jonas Ecker, Till Milde, Andreas von Deimling, Andrey Korshunov, Arie Perry, Stefan M. Pfister, Felix Sahm, David A. Solomon, David T. W. Jones
Summary: Pediatric central nervous system (CNS) tumors are the leading cause of cancer-related death in children aged 0-14 years. A newly identified CNS tumor type characterized by PLAGL1/2 amplification and a lack of recurrent genetic alterations has been described. These tumors are composed of primitive embryonal-like cells and are associated with intermediate survival, but the cell of origin and optimal treatment strategies are yet to be determined.
ACTA NEUROPATHOLOGICA
(2023)
Article
Pathology
Madeleine R. Berendsen, Diede A. G. van Bladel, Eva Hesius, Fleur A. de Groot, Leonie I. Kroeze, Jos Rijntjes, Jeroen A. C. W. Luijks, Brigiet Hoevenaars, Altuna Halilovic, Peet Nooijen, Esther van Bladel, Susan de Jonge-Peeters, Chantal Lensen, Hans Pruijt, Ellen van der Spek, Joost S. P. Vermaat, Corine Hess, Konnie M. Hebeda, Wendy B. C. Stevens, J. Han J. M. van Krieken, Michiel van den Brand, Patricia J. T. A. Groenen, Blanca Scheijen
Summary: This study established the clonal relationship between diagnoses and recurrences of diffuse large B-cell lymphoma (DLBCL) using next-generation sequencing-based detection. Among the 50 patients with interpretable results, 86% developed clonally related relapsed disease, while 14% displayed different dominant clonotypes, confirming the occurrence of second primary DLBCL. Late recurrences should consider next-generation sequencing-based clonality testing to distinguish relapse from second primary lymphoma.
Correction
Clinical Neurology
Michaela-Kristina Keck, Martin Sill, Andrea Wittmann, Piyush Joshi, Damian Stichel, Pengbo Beck, Konstantin Okonechnikow, Philipp Sievers, Annika K. Wefers, Federico Roncaroli, Shivaram Avula, Martin G. McCabe, James T. Hayden, Pieter Wesseling, Ingrid Ora, Monica Nister, Mariette E. G. Kranendonk, Bastiaan B. J. Tops, Michal Zapotocky, Josef Zamecnik, Alexandre Vasiljevic, Tanguy Fenouil, David Meyronet, Katja von Hoff, Ulrich Schueller, Hugues Loiseau, Dominique Figarella-Branger, Christof M. Kramm, Dominik Sturm, David Scheie, Tuomas Rauramaa, Jouni Pesola, Johannes Gojo, Christine Haberler, Sebastian Brandner, Tom Jacques, Alexandra Sexton Oates, Richard Saffery, Ewa Koscielniak, Suzanne J. Baker, Stephen Yip, Matija Snuderl, Nasir Ud Din, David Samuel, Kathrin Schramm, Mirjam Blattner-Johnson, Florian Selt, Jonas Ecker, Till Milde, Andreas von Deimling, Andrey Korshunov, Arie Perry, Stefan M. Pfister, Felix Sahm, David A. Solomon, David T. W. Jones
ACTA NEUROPATHOLOGICA
(2023)
Article
Oncology
Lisanne Verhoef, Maaike C. G. Bleeker, Nicole Polman, Renske D. M. Steenbergen, Renee M. F. Ebisch, Willem J. G. Melchers, Ruud L. M. Bekkers, Anco C. Molijn, Wim G. Quint, Folkert van Kemenade, Chris J. L. M. Meijer, Johannes Berkhof, Danielle A. M. Heideman
Summary: This study evaluated the use of DNA methylation analysis as a triage method for high-risk HPV-positive self-collected cervicovaginal samples in cervical cancer screening. The methylation markers ASCL1 and LHX8 showed a sensitivity of 73.3% and specificity of 61.1% for detecting CIN3+. Compared to clinician-collected samples, self-collected samples had a relative sensitivity of 0.95 and relative specificity of 0.82. Therefore, the ASCL1/LHX8 methylation marker panel is a feasible triage method for HPV-positive women participating in routine self-sampling.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
G. Tjitske Los-de Vries, Phylicia Stathi, Ryanne Rutkens, Nathalie J. Hijmering, Jeroen A. C. W. Luijks, Patricia J. T. A. Groenen, Daphne de Jong, Bauke Ylstra, Margaretha G. M. Roemer
Summary: Primary and relapsed LBCL-IP have a common set of genetic alterations that support survival and proliferation, providing insight into the disease progression.
Article
Oncology
Hilliene J. van de Schootbrugge-Vandermeer, Iris Lansdorp-Vogelaar, Lucie de Jonge, Anneke J. van Vuuren, Evelien Dekker, Manon C. W. Spaander, Christian R. B. Ramakers, Iris D. Nagtegaal, Folkert J. van Kemenade, Monique E. van Leerdam, Esther Toes-Zoutendijk
Summary: In the Dutch CRC screening programme, individuals who are single, have an immigrant background, and have low income are less likely to participate. Targeted interventions are needed to reduce inequalities.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Endocrinology & Metabolism
Evert F. S. van Velsen, Robin P. Peeters, Merel T. Stegenga, Uwe Maeder, Christoph Reiners, Folkert J. van Kemenade, Tessa M. van Ginhoven, W. Edward Visser, Frederik A. Verburg
Summary: The relationship between tumor size and advanced disease in thyroid cancer patients differs between Dutch and German populations. In the Dutch population, the proportion of papillary thyroid cancer (PTC) patients with lymph node metastases is significantly higher than in the German population for tumors ≤ 1 cm (45% vs. 14%). Moreover, the occurrence of distant metastases in differentiated thyroid cancer (DTC) patients is significantly higher in the Dutch compared to the German population for tumors ≤ 2 cm (7% vs. 2%).
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Esther Toes-Zoutendijk, Lucie de Jonge, Carola Adriana van Iersel, Manon C. W. Spaander, Anneke J. van Vuuren, Folkert van Kemenade, Christian R. Ramakers, Evelien Dekker, Iris D. Nagetaal, Monique E. van Leerdam, Iris Lansdorp-Vogelaar
Summary: The study assessed the impact of delayed invitation on screen-detected and interval colorectal cancers (CRC) in a FIT-based CRC screening program. Individual-level data from individuals who participated in 2017 and 2018 with a negative FIT and were eligible for screening in 2019 and 2020 were analyzed. The results showed that the first COVID-19 wave had a modest impact on screening yield, and a small proportion of FIT negatives had interval CRC, possibly due to an extended invitation interval.
Article
Cell Biology
Eva A. M. Hesius, Lidia van Laar, Margriet Oosterveld, Annemiek B. van Spriel, Blanca Scheijen, Jan Willem Leeuwis, Henri A. M. Marres, Patricia J. T. A. Groenen, Wendy B. C. Stevens, Ellen van Der Spek, Adriaan J. C. van den Brule, Brigiet M. Hoevenaars, Konnie M. Hebeda, Michiel van den Brand
Summary: LBCL-IRF4 is a newly identified subtype of large B cell lymphoma in the 2017 revised WHO classification, initially reported in children. This study aimed to assess the frequency of IRF4 rearrangements in adult DLBCLs that need to be reclassified as LBCL-IRF4 using FISH. Among 238 DLBCL patients, six (including the index patient) were found to have IRF4 rearrangements, and their immunohistochemical profile was consistent with LBCL-IRF4. This study highlights the importance of considering LBCL-IRF4 in older patients and at different anatomical sites.
Review
Oncology
Felix Sahm, Sebastian Brandner, Luca Bertero, David Capper, Pim J. French, Dominique Figarella-Branger, Felice Giangaspero, Christine Haberler, Monika E. Hegi, Bjarne W. Kristensen, Kathreena M. Kurian, Matthias Preusser, Bastiaan B. J. Tops, Martin van den Bent, Wolfgang Wick, Guido Reifenberger, Pieter Wesseling
Summary: In the 5th edition of the WHO CNS tumor classification, molecular characteristics have become important diagnostic criteria for many CNS tumor types. This guideline focuses on the methods used for diagnosing gliomas, glioneuronal, and neuronal tumors using informative molecular markers. Various molecular methods are discussed, including next-generation sequencing, methylation profiling, and immunohistochemistry. The guideline also covers the analysis of MGMT promoter methylation status, and provides an overview of the advantages, limitations, and requirements of different assays. The importance of molecular diagnostic testing in neuro-oncology is emphasized, along with discussions on clinical relevance, accessibility, cost, and ethical aspects.
Article
Oncology
Patricia J. T. A. Groenen, Michiel van den Brand, Leonie I. Kroeze, Avital L. Amir, Konnie M. Hebeda
Summary: Clonality assessment using the rearrangements of immunoglobulin and T-cell receptor genes is commonly used for diagnosing B-cell and T-cell lymphoma. The EuroClonality NGS Working Group has developed a next-generation sequencing-based clonality assay for detecting these gene rearrangements in formalin-fixed and paraffin-embedded tissues. This technology offers more sensitive detection and precise comparison of clones compared to conventional fragment-based analysis, and has potential applications in pathology for various lymphoproliferative disorders.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Ianthe A. E. M. van Belzen, Casey Cai, Marc van Tuil, Shashi Badloe, Eric Strengman, Alex Janse, Eugene T. P. Verwiel, Douwe F. M. van der Leest, Lennart Kester, Jan J. Molenaar, Jules Meijerink, Jarno Drost, Weng Chuan Peng, Hindrik H. D. Kerstens, Bastiaan B. J. Tops, Frank C. P. Holstege, Patrick Kemmeren, Jayne Y. Hehir-Kwa
Summary: The study developed a method called Fusion-sq, which integrates evidence from RNA sequencing and whole genome sequencing to detect tumor-specific gene fusions. In a pediatric pan-cancer cohort, 155 high confidence tumor-specific gene fusions were identified, and their potential pathological effects were investigated. This method can be used for precision oncology applications and provides multi-omics evidence for clinical decision-making.
Article
Otorhinolaryngology
Ivona Loncar, Evert F. S. van Velsen, Elske T. Massolt, Folkert J. van Kemenade, Adriana C. H. van Engen-van Grunsven, Bettien M. van Hemel, Francien H. van Nederveen, Romana Netea-Maier, Thera P. Links, Robin P. Peeters, Tessa M. van Ginhoven
Summary: This study evaluated the clinical utility of the Gene Expression Classifier (GEC) and Genomic Sequencing Classifier (GSC) in a European population. The results showed that the GEC was not clinically useful in identifying benign lesions in indeterminate nodules, especially in oncocytic nodules. The GSC misclassified some malignant lesions as benign.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Electra Sofou, Elisavet Vlachonikola, Laura Zaragoza-Infante, Monika Brueggemann, Nikos Darzentas, Patricia J. T. A. Groenen, Michael Hummel, Elizabeth A. Macintyre, Fotis Psomopoulos, Frederic Davi, Anton W. Langerak, Kostas Stamatopoulos
Article
Oncology
Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannick P. Kok, Shibo Yu, Jana Dobrovolna, Pavel Janscak, Marcel van Vugt, Libor Macurek
Summary: Oncogene-induced replication stress is a major cause of genome instability in cancer cells. This study reveals that increased activity of PPM1D exacerbates replication stress caused by cyclin E1 overexpression, leading to abnormal cell cycle progression and accumulation of DNA copy number alterations. Pharmacological inhibition of PPM1D can alleviate replication stress-induced genome instability.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Alamelu G. Bharadwaj, Meghan E. McLean, Margaret L. Dahn, Hannah F. Cahill, Marie-Claire D. Wasson, Raj Pranap Arun, Olivia L. Walker, Brianne M. Cruickshank, Wasundara Fernando, Jaganathan Venkatesh, Penelope J. Barnes, Gillian Bethune, Gregory Knapp, Lucy K. Helyer, Carman A. Giacomantonio, David M. Waisman, Paola Marcato
Summary: ALDH1A3 regulates the plasminogen activation pathway to promote breast cancer metastasis. Co-expression of ALDH1A3 and tPA is associated with TNBC subtype, high tumor grade, and recurrent metastatic disease.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas de Laat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. Primary fibrinolytic protease plasminogen promotes PDAC tumor growth and metastatic potential through engaging plasminogen receptors on tumor cells.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nuria Gendrau-Sanclemente, Agnes Figueras, Kristina Gracova, Alvaro Lahiguera, Elisenda Alsina-Sanchis, Juan A. Marin-Jimenez, August Vidal, Xavier Matias-Guiu, Sergi Fernandez-Gonzalez, Marc Barahona, Lola Marti, Jordi Ponce, Francesc Vinals
Summary: High-grade serous ovarian cancer (HGSOC), the deadliest gynecological malignancy, spreads through transcoelomic dissemination. This study reveals that platelet-derived growth factor receptor beta (PDGFRβ) is essential for the formation of tumorspheres in HGSOC. Inhibition of PDGFRβ blocks the clustering of ovarian cancer cells and prevents peritoneal dissemination.
MOLECULAR ONCOLOGY
(2024)
