Obatoclax potentiates the cytotoxic effect of cytarabine on acute myeloid leukemia cells by enhancing DNA damage

Acute myeloid leukemia cells harboring MLL fusion genes or with the acute promyelocytic leukemia phenotype are sensitive to the Bcl-2-selective inhibitor ABT-199

(2014) X Niu et al.   LEUKEMIA

Non-apoptotic roles of Bcl-2 family: The calcium connection

(2013) Benjamin Bonneau et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia

(2013) K. A. Urtishak et al.   BLOOD

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Overexpression of GATA1 Confers Resistance to Chemotherapy in Acute Megakaryocytic Leukemia

(2013) John Timothy Caldwell et al.   PLoS One

Panobinostat Enhances Cytarabine and Daunorubicin Sensitivities in AML Cells through Suppressing the Expression of BRCA1, CHK1, and Rad51

(2013) Chengzhi Xie et al.   PLoS One

Autophagy contributes to modulating the cytotoxicities of Bcl-2 homology domain-3 mimetics

(2013) Le Yu et al.   SEMINARS IN CANCER BIOLOGY

Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process

(2012) M. Rahmani et al.   BLOOD

BCL2 Suppresses PARP1 Function and Nonapoptotic Cell Death

(2012) Chaitali Dutta et al.   CANCER RESEARCH

Phospho-Bcl-xL(Ser62) plays a key role at DNA damage-induced G2checkpoint

(2012) Jianfang Wang et al.   CELL CYCLE

Valproic acid synergistically enhances the cytotoxicity of clofarabine in pediatric acute myeloid leukemia cells

(2012) Chengzhi Xie et al.   PEDIATRIC BLOOD & CANCER

Bcl-2 Inhibits Nuclear Homologous Recombination by Localizing BRCA1 to the Endomembranes

(2011) C. Laulier et al.   CANCER RESEARCH

BH3 mimetics activate multiple pro-autophagic pathways

(2011) S A Malik et al.   ONCOGENE

Inhibition of Histone Deacetylases 1 and 6 Enhances Cytarabine-Induced Apoptosis in Pediatric Acute Myeloid Leukemia Cells

(2011) Xuelian Xu et al.   PLoS One

The BH3-mimetic GX15-070 induces autophagy, potentiates the cytotoxicity of carboplatin and 5-fluorouracil in esophageal carcinoma cells

(2010) Jingxuan Pan et al.   CANCER LETTERS

MCL-1 localizes to sites of DNA damage and regulates DNA damage response

(2010) Sarwat Jamil et al.   CELL CYCLE

ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response

(2010) P Pawlikowska et al.   CELL DEATH AND DIFFERENTIATION

The Combination of a Histone Deacetylase Inhibitor with the Bcl-2 Homology Domain-3 Mimetic GX15-070 Has Synergistic Antileukemia Activity by Activating Both Apoptosis and Autophagy

(2010) Y. Wei et al.   CLINICAL CANCER RESEARCH

Phase I Dose Finding Studies of Obatoclax (GX15-070), a Small Molecule Pan-BCL-2 Family Antagonist, in Patients with Advanced Solid Tumors or Lymphoma

(2010) J. J. Hwang et al.   CLINICAL CANCER RESEARCH

Mechanisms of Synergistic Antileukemic Interactions between Valproic Acid and Cytarabine in Pediatric Acute Myeloid Leukemia

(2010) C. Xie et al.   CLINICAL CANCER RESEARCH

Drugs targeting Bcl-2 family members as an emerging strategy in cancer

(2010) Brian Leber et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Anti-apoptotic Protein BCL2 Down-regulates DNA End Joining in Cancer Cells

(2010) Tadi Satish Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial

(2010) Jeffrey E Rubnitz et al.   LANCET ONCOLOGY

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

PARP-1 is involved in autophagy induced by DNA damage

(2009) José Antonio Muñoz-Gámez et al.   Autophagy

RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia

(2009) H. Edwards et al.   BLOOD

Different forms of cell death induced by putative BCL2 inhibitors

(2009) M Vogler et al.   CELL DEATH AND DIFFERENTIATION

Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia

(2008) S. M. O'Brien et al.   BLOOD

Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax)

(2008) M. Konopleva et al.   CANCER RESEARCH

A Phase I Study of the Pan Bcl-2 Family Inhibitor Obatoclax Mesylate in Patients with Advanced Hematologic Malignancies

(2008) A. D. Schimmer et al.   CLINICAL CANCER RESEARCH

An Essential Role for MCL-1 in ATR-mediated CHK1 Phosphorylation

(2008) Sarwat Jamil et al.   MOLECULAR BIOLOGY OF THE CELL

Bcl2 Negatively Regulates DNA Double-Strand-Break Repair through a Nonhomologous End-Joining Pathway

(2008) Qinhong Wang et al.   MOLECULAR CELL