Combination of Vorinostat and caspase-8 inhibition exhibits high anti-tumoral activity on endometrial cancer cells

A Rationally Designed Histone Deacetylase Inhibitor with Distinct Antitumor Activity against Ovarian Cancer

(2015) Ya-Ting Yang et al.   NEOPLASIA

Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis

(2012) E Kerr et al.   CELL DEATH AND DIFFERENTIATION

Endometrial carcinoma: molecular alterations involved in tumor development and progression

(2012) A Yeramian et al.   ONCOGENE

Survival Function of the FADD-CASPASE-8-cFLIPL Complex

(2012) Christopher P. Dillon et al.   Cell Reports

KSR1 Is Overexpressed in Endometrial Carcinoma and Regulates Proliferation and TRAIL-Induced Apoptosis by Modulating FLIP Levels

(2011) David Llobet et al.   AMERICAN JOURNAL OF PATHOLOGY

Proliferative versus apoptotic functions of caspase-8

(2011) Bram J. van Raam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Vorinostat/SAHA-induced apoptosis in malignant mesothelioma is FLIP/caspase 8-dependent and HR23B-independent

(2011) Jane L. Hurwitz et al.   EUROPEAN JOURNAL OF CANCER

Histone Deacetylase Inhibitors in the Treatment of Hematological Malignancies

(2011) A. Petrella et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Sodium butyrate-induced DAPK-mediated apoptosis in human gastric cancer cells

(2011) HYUNSOO SHIN et al.   ONCOLOGY REPORTS

Vorinostat Induces Reactive Oxygen Species and DNA Damage in Acute Myeloid Leukemia Cells

(2011) Luca A. Petruccelli et al.   PLoS One

The Mechanism of Action of the Histone Deacetylase Inhibitor Vorinostat Involves Interaction with the Insulin-Like Growth Factor Signaling Pathway

(2011) Rive Sarfstein et al.   PLoS One

Histone deacetylase inhibitors synergistically potentiate death receptor 4-mediated apoptotic cell death of human T-cell acute lymphoblastic leukemia cells

(2010) Eun-Sil Sung et al.   APOPTOSIS

The multikinase inhibitor Sorafenib induces apoptosis and sensitises endometrial cancer cells to TRAIL by different mechanisms

(2010) D. Llobet et al.   EUROPEAN JOURNAL OF CANCER

Itch/AIP4-independent proteasomal degradation of cFLIP induced by the histone deacetylase inhibitor SAHA sensitizes breast tumour cells to TRAIL

(2010) Rosario Yerbes et al.   INVESTIGATIONAL NEW DRUGS

Multigene Expression-Based Predictors for Sensitivity to Vorinostat and Velcade in Non-Small Cell Lung Cancer

(2010) A. S. Nagji et al.   MOLECULAR CANCER THERAPEUTICS

HDAC inhibitor-based therapies and haematological malignancy

(2009) L. Stimson et al.   ANNALS OF ONCOLOGY

Caspase-8 Association with the Focal Adhesion Complex Promotes Tumor Cell Migration and Metastasis

(2009) S. Barbero et al.   CANCER RESEARCH

Vorinostat Inhibits Brain Metastatic Colonization in a Model of Triple-Negative Breast Cancer and Induces DNA Double-Strand Breaks

(2009) D. Palmieri et al.   CLINICAL CANCER RESEARCH

The histone deacetylase inhibitor suberoylanilide hydroxamic acid sensitises human hepatocellular carcinoma cells to TRAIL-induced apoptosis by TRAIL-DISC activation

(2009) Daniela Carlisi et al.   EUROPEAN JOURNAL OF CANCER

Histone deacetylase inhibitors: Potential in cancer therapy

(2009) P.A. Marks et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Rab5 Mediates Caspase-8–promoted Cell Motility and Metastasis

(2009) Vicente A. Torres et al.   MOLECULAR BIOLOGY OF THE CELL

Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms

(2009) T. Walker et al.   MOLECULAR PHARMACOLOGY

Histone deacetylase inhibitors induce thyroid cancer-specific apoptosis through proteasome-dependent inhibition of TRAIL degradation

(2009) E Borbone et al.   ONCOGENE

Histone deacetylase inhibitors: Mechanisms of cell death and promise in combination cancer therapy

(2008) Jennifer S. Carew et al.   CANCER LETTERS

Vorinostat and Sorafenib Synergistically Kill Tumor Cells via FLIP Suppression and CD95 Activation

(2008) G. Zhang et al.   CLINICAL CANCER RESEARCH

Identification of a Critical Tyrosine Residue in Caspase 8 That Promotes Cell Migration

(2008) Simone Barbero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist

(2008) A. J. Frew et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA