What are the best routes to effectively model human colorectal cancer?

Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis

(2011) H Nikki March et al.   NATURE GENETICS

An Integrated Approach to Uncover Drivers of Cancer

(2010) Uri David Akavia et al.   CELL

A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer

(2010) Roberta Pang et al.   Cell Stem Cell

Curcumin enhances dasatinib-induced inhibition of growth and transformation of colon cancer cells

(2010) Jyoti Nautiyal et al.   INTERNATIONAL JOURNAL OF CANCER

The Mutyh Base Excision Repair Gene Influences the Inflammatory Response in a Mouse Model of Ulcerative Colitis

(2010) Ida Casorelli et al.   PLoS One

Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment

(2010) K. E. Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Receptor Tyrosine Kinase EPHB4 Has Tumor Suppressor Activities in Intestinal Tumorigenesis

(2009) H. Dopeso et al.   CANCER RESEARCH

Genetic mapping of Mom5 , a novel modifier of Apc Min -induced intestinal tumorigenesis

(2009) Seija I. Oikarinen et al.   CARCINOGENESIS

Clinicopathological significance of nuclear PTEN expression in colorectal adenocarcinoma

(2009) Ki-Seok Jang et al.   HISTOPATHOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Transforming growth factor-β signaling in epithelial-mesenchymal transition and progression of cancer

(2009) Kohei MIYAZONO   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Transcription Factor PROX1 Induces Colon Cancer Progression by Promoting the Transition from Benign to Highly Dysplastic Phenotype

(2008) Tatiana V. Petrova et al.   CANCER CELL

Deficiency of Mbd2 Attenuates Wnt Signaling

(2008) T. J. Phesse et al.   MOLECULAR AND CELLULAR BIOLOGY

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation

(2008) Victoria Marsh et al.   NATURE GENETICS