ALDH+ tumor-initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ-secretase inhibitor and irinotecan in colorectal cancer

A phase I dose-escalation study of the novel gamma secretase inhibitor PF-03084014 in patients (pts) with advanced solid tumors.

(2017) W. A. Messersmith et al.   JOURNAL OF CLINICAL ONCOLOGY

Differentiated Human Colorectal Cancer Cells Protect Tumor-Initiating Cells From Irinotecan

(2011) Benjamin L. Emmink et al.   GASTROENTEROLOGY

High Level of Notch1 Protein is Associated with Poor Overall Survival in Colorectal Cancer

(2010) Dake Chu et al.   ANNALS OF SURGICAL ONCOLOGY

Notch1 regulates the growth of human colon cancers

(2010) Yan Zhang et al.   CANCER

NOTCH Signaling Is Required for Formation and Self-Renewal of Tumor-Initiating Cells and for Repression of Secretory Cell Differentiation in Colon Cancer

(2010) S. S. Sikandar et al.   CANCER RESEARCH

Targeting Notch to Target Cancer Stem Cells

(2010) A. Pannuti et al.   CLINICAL CANCER RESEARCH

Cancer Statistics, 2009

(2009) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Aldehyde Dehydrogenase-Expressing Colon Stem Cells Contribute to Tumorigenesis in the Transition from Colitis to Cancer

(2009) J. E. Carpentino et al.   CANCER RESEARCH

Aldehyde Dehydrogenase 1 Is a Marker for Normal and Malignant Human Colonic Stem Cells (SC) and Tracks SC Overpopulation during Colon Tumorigenesis

(2009) E. H. Huang et al.   CANCER RESEARCH

 -Secretase Inhibitors Abrogate Oxaliplatin-Induced Activation of the Notch-1 Signaling Pathway in Colon Cancer Cells Resulting in Enhanced Chemosensitivity

(2009) R. D. Meng et al.   CANCER RESEARCH

DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency

(2009) Timothy Hoey et al.   Cell Stem Cell

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

(2009) Bin-Bing S. Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells

(2008) Tamara Aleksic et al.   Cell Communication and Signaling

Notch1 Expression in Colorectal Carcinoma Determines Tumor Differentiation Status

(2008) Dake Chu et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Identification of cells initiating human melanomas

(2008) Tobias Schatton et al.   NATURE