Article
Nutrition & Dietetics
Dong Hoon Lee, Fred K. Tabung, Edward L. Giovannucci
Summary: This study found that higher intake of animal protein is associated with higher levels of IGF-1 and lower levels of IGFBP-1 and IGFBP-2, while higher intake of plant protein is associated with higher levels of IGF-1 and IGFBP-1. These associations are more significant in participants with unhealthy lifestyle risk factors.
CLINICAL NUTRITION
(2022)
Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Article
Medicine, General & Internal
Xiaohui Wang, Jia Li, Wei Zhang, Feng Wang, Yunzi Wu, Yulin Guo, Dong Wang, Xinfeng Yu, Ang Li, Fei Li, Yibin Xie
Summary: This study reveals that tumor-derived IGFBP-3 plays a critical role in cancer-associated cachexia by causing lipid loss in mature adipocytes. IGFBP-3 antagonizes insulin/IGF-like signaling and impairs the balance between lipolysis and lipogenesis. The findings suggest that tumor-derived IGFBP-3 may serve as a biomarker for the diagnosis of cachexia in cancer patients.
CHINESE MEDICAL JOURNAL
(2023)
Review
Chemistry, Medicinal
Fatemeh Meshkini, Nahid Ramezani-Jolfaie, Saman Sargazi, Cain C. T. Clark, Sepideh Soltani
Summary: A systematic review of the effects of lycopene on circulating IGF-1 and IGFBPs in adults found no consistent modifying effect of lycopene supplementation on IGF-1 and IGFBP levels. More research is needed to explore the effect of lycopene on the IGF-1 system.
PHYTOTHERAPY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Francesca D'Addio, Anna Maestroni, Emma Assi, Moufida Ben Nasr, Giovanni Amabile, Vera Usuelli, Cristian Loretelli, Federico Bertuzzi, Barbara Antonioli, Francesco Cardarelli, Basset El Essawy, Anna Solini, Ivan C. Gerling, Cristina Bianchi, Gabriella Becchi, Serena Mazzucchelli, Domenico Corradi, Gian Paolo Fadini, Diego Foschi, James F. Markmann, Emanuela Orsi, Jan Skrha, Maria Gabriella Camboni, Reza Abdi, A. M. James Shapiro, Franco Folli, Johnny Ludvigsson, Stefano Del Prato, Gianvincenzo Zuccotti, Paolo Fiorina
Summary: In this study, the Authors demonstrated that the IGFBP3/TMEM219 pathway plays a crucial role in regulating pancreatic beta cell homeostasis and its dysregulation is associated with diabetes. Targeting the IGFBP3/TMEM219 pathway may be a potential therapeutic option for treating diabetes.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Danbi Lee, Jungho Ahn, Hwa Seon Koo, Youn-Jung Kang
Summary: Adequate endometrial growth is crucial for successful embryo implantation and pregnancy maintenance. In this study, we demonstrated that intrauterine administration of botulinum toxin A (BoTA) effectively improved the uterine structural and functional repair in a murine model with thin endometrium. This therapeutic effect is mediated by insulin-like growth factor binding protein-3 (IGFBP3)-dependent osteopontin (OPN) proteolytic cleavage.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Yuqing Yang, Junpen Suwimonteerabutr, Taweepoke Angkawanish, Kaywalee Chatdarong
Summary: The study in Thailand identified a low fertility rate in Asian elephants and investigated the relationship between insulin-like growth factor-1 (IGF-1) and male infertility. They found a positive correlation between serum IGF-1 concentration and acrosome integrity in sperm, as well as a positive correlation with testosterone levels. Seminal IGF-1 concentrations were undetectable, but serum IGF-1 concentration was considered a potential biomarker of normal testicular functions and spermatogenesis in elephants.
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Layla Damen, Melitza S. M. Elizabeth, Stephany H. Donze, Sjoerd A. A. van den Berg, Laura C. G. de Graaff, Anita C. S. Hokken-Koelega
Summary: In children with Prader-Willi syndrome receiving GH treatment, high immunoreactive IGF-I levels are often observed, while free IGF-I levels are low, indicating a significant discrepancy between the two.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Can -Tong Liu, Fang-Cai Wu, Yi-Xuan Zhuang, Xin-Yi Huang, Xin-Hao Li, Qi-Qi Qu, Yu-Hui Peng, Yi-Wei Xu, Shu-Lin Chen, Xu-Chun Huang
Summary: This study suggests that serum IGFBP7 may serve as a potential early diagnostic marker for gastric cancers.
Review
Biochemistry & Molecular Biology
Sandra Diaz del Moral, Maha Benaouicha, Ramon Munoz-Chapuli, Rita Carmona
Summary: The translation introduces the importance of insulin and insulin-like growth factors during embryonic development and their role in cardiac development and cardiomyocyte proliferation. The study also discusses the clinical potential of utilizing the IGF signaling pathway for adult cardiac repair and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Environmental Sciences
Chiara Talia, Lisa Connolly, Paul A. Fowler
Summary: This review discusses the effects of endocrine disruptors on the IGF system, focusing on different categories of EDs and their potential molecular mechanisms. While there is a lack of studies linking ED exposure to changes in IGF levels for some ED classes, this remains an area of concern that requires further research to improve reproducibility and determine the degree of risk EDs pose to the IGF system.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Biochemical Research Methods
Mark S. Pratt, Martijn van Faassen, Noah Remmelts, Rainer Bischoff, Ido P. Kema
Summary: This study presents a simple and fast antibody-free LC-MS/MS method for the quantification of intact IGF-1 and IGF-2 in human plasma, allowing for reliable and simultaneous quantification without the need for enzymatic digestion. The method offers advantages of speed, accuracy, and potential wide application in clinical mass spectrometry laboratories.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Toxicology
Estela J. Jauregui, Maile McSwain, Xiaosong Liu, Kara Miller, Kimberlie Burns, Zelieann R. Craig
Summary: Phthalate exposure in women has been associated with reduced ovarian reserve and oocyte retrieval. In this study, we investigated the effects of di-n-butyl phthalate (DBP) exposure on the insulin-like growth factor 1 (IGF1) signaling in the ovary and found that DBP reduced Igf1 and Igf1r expression, as well as the number of ovarian follicles. These findings provide insight into how phthalates could influence the ovarian reserve in females.
TOXICOLOGICAL SCIENCES
(2023)
Article
Pediatrics
Chi Zhang, Xiaowan Du, Jingjing Li, Junbo Zhang, Guoping Yin
Summary: The study aimed to investigate the effect of daily duration of chronic intermittent hypoxia (CIH) exposure on circulating growth hormone (GH)/insulin-like growth factor-1 (IGF-1) concentrations and body weight changes of premature rats. The results showed that increasing the daily duration of CIH exposure decreased circulating GH/IGF-1 concentrations and caused growth delay in premature rats.
FRONTIERS IN PEDIATRICS
(2023)
Article
Water Resources
Geofrey J. Mchau, Revocatus Machunda, Martin Kimanya, Edna Makule, Yun Yun Gong, Emmanuel Mpolya, Julie P. Meneely, Christopher T. Elliott, Brett Greer
Summary: The study conducted in Lake Victoria in Tanzania found the presence of multiple cyanotoxins in freshwater, with cylindrospermopsin being the most abundant toxin detected. Microcystins and anatoxin-a were also detected but in lower concentrations compared to cylindrospermopsin. This study highlights the potential health risks associated with the presence of cyanotoxins in freshwater environments.
EXPOSURE AND HEALTH
(2021)
Article
Chemistry, Applied
Zhikun Yang, Xiaodong Zhai, Xiaobo Zou, Jiyong Shi, Xiaowei Huang, Zhihua Li, Yunyun Gong, Melvin Holmes, Megan Povey, Jianbo Xiao
Summary: Bilayer colorimetric films containing gelatin-ZnO and gellan gum-MBA were developed for fish spoilage monitoring. The films showed improved color stability and NH3 sensitivity with increased ZnO content, suitable for printing and detecting fish spoilage.
Article
Food Science & Technology
Xiaodan Wang, Nannan Qiu, Chi Zhang, Shuang Zhou, Yunfeng Zhao, Yongning Wu, Yun Yun Gong
Summary: This study evaluated DON exposure in 199 Chinese population samples from Anhui Province, with the highest concentrations found in wheat-based products. Adolescents showed elevated contaminant levels, indicating a potential health risk. The excretion rate of adolescents was approximately 2.5 times that of adult participants, possibly indicative of higher metabolic activity, requiring further investigation.
Article
Agronomy
Yong Dou, Michael N. Routledge, Yunyun Gong, Esa Abiso Godana, Solairaj Dhanasekaran, Qiya Yang, Xiaoyun Zhang, Hongyin Zhang
Summary: Penicillium expansum is a major postharvest fungal pathogen causing blue mold decay in apples. ε-Poly-L-lysine has strong antimicrobial activity and has been found to effectively inhibit the growth of P. expansum in apples. The inhibition may be due to the activation of defense-related enzyme activity and gene expression in apple fruit tissues.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Hifza Rasheed, Ya Xu, Martin E. Kimanya, Xiaoxi Pan, Zhihua Li, Xiaobo Zou, Candida P. Shirima, Melvin Holmes, Michael N. Routledge, Yun Yun Gong
Summary: Numerous population-based studies have shown a high prevalence of aflatoxin-associated childhood stunting in low-income countries, causing a significant disease burden for children under five. The study estimated DALYs and PAR for aflatoxin-related stunting and the co-occurrence of stunting and underweight, revealing the importance of reducing aflatoxin exposure in high-exposure areas to improve child health outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Usama Nasir, Iqra Naeem, Muhammad Asif, Amir Ismail, Yun Yun Gong, Michael N. Routledge, Adnan Amjad, Ambreen Fazal, Zubair Ismail
Summary: This study investigated aflatoxin exposure in children from different socioeconomic classes in Multan city, Pakistan. 11% of urine samples were found to contain aflatoxins, and the poor health status of the children was observed. This highlights the need for monitoring aflatoxin contamination in baby foods and interventions focusing on food safety awareness.
Review
Food Science & Technology
Amir Ismail, Iqra Naeem, Yun Yun Gong, Michael N. Routledge, Saeed Akhtar, Muhammad Riaz, Leandra Naira Zambelli Ramalho, Carlos Augusto Fernandes de Oliveira, Zubair Ismail
Summary: The early stages of human life are crucial for growth and development, but exposure to toxins like aflatoxins can lead to severe health complications, especially in countries in Africa and Asia. Even with regulations in place, aflatoxins can still be found in infant foods in developing countries, highlighting the need for further efforts to reduce exposure.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Medicine, General & Internal
Ya Xu, Sophie Moore, Gaoyun Chen, Patrick Nshe, Tisbeh Faye-Joof, Andrew Prentice, Yun Yun Gong, Michael Routledge
Summary: Chronic aflatoxin exposure in early infancy in sub-Saharan Africa may have a negative impact on immune development, particularly affecting thymus growth and function.
Article
Food Science & Technology
Qiya Yang, Xin Qian, Michael N. Routledge, Xiangyang Wu, Yu Shi, Qigai Zhu, Hongyin Zhang
Summary: This study investigated the metabolomics of Citrus reticulata Blanco wounds before and after infection with Penicillium digitatum, revealing significant changes in metabolites and physiological processes. By combining multiple analytical methods, the study provided insights into the pathogenesis of green mold disease in postharvest citrus and laid the groundwork for new control strategies.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Dhanasekaran Solairaj, Qiya Yang, Ngolong Ngea Guillaume Legrand, Michael N. Routledge, Hongyin Zhang
Summary: This review paper explores the pathways of fungal pathogenesis in grapes and the environmental factors affecting fungal infections. It emphasizes the molecular aspects of interaction between grape fungal pathogens and grape, as well as recent innovations in control strategies.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Biology
Matt J. Silver, Ayden Saffari, Noah J. Kessler, Gririraj R. Chandak, Caroline H. D. Fall, Prachand Issarapu, Akshay Dedaniya, Modupeh Betts, Sophie E. Moore, Michael N. Routledge, Zdenko Herceg, Cyrille Cuenin, Maria Derakhshan, Philip T. James, David Monk, Andrew M. Prentice
Summary: This study analyzed data from rural Gambia to investigate the associations between season of conception (SoC) and DNA methylation. The researchers identified 259 CpG sites that showed consistent associations with SoC and DNA methylation. These associations were most apparent in early infancy and attenuated by mid-childhood. The study also found that the SoC-associated CpG sites were influenced by environmental factors and were enriched for certain genomic regions and epigenetic mechanisms.
Article
Biochemical Research Methods
Chang Han, Yulong Wang, Pengyan Liu, Pan Li, Beibei Liu, Ning Ding, Michael N. Routledge, Zhengjiang Liu, Cunzheng Zhang
Summary: In this study, three haptens were designed and synthesized to generate monoclonal antibodies with broad recognition of multiple variants of PCBs. By using aggregation-induced emission luminogen nanobeads as the tracer, the sensitivity of the detection was significantly improved. The developed assay is a simple, broad-spectrum, and sensitive tool for large-scale screening of PCBs in food.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Food Science & Technology
Lei Xia, Hifza Rasheed, Michael N. Routledge, Hang Wu, Yun Yun Gong
Summary: The study revealed high levels of mycotoxin exposure in the Pakistani population, with particular concern for aflatoxin B-1 and ochratoxin A. Further management is needed to address the health risks associated with exposure to these mycotoxins.
Article
Chemistry, Analytical
Xiaoou Wei, Chao Liu, Xinai Zhang, Zhihua Li, Xinyu Wang, Yiwei Xu, Jiyong Shi, Quancai Sun, Michael N. Routledge, Di Zhang, Xiaobo Zou
Summary: This study presents an integrated 3D cell-based electrochemical biosensor to evaluate the neurotoxicity of organophosphorus pesticides (OPs). The sensor uses OPs to inhibit the activity of intracellular acetylcholinesterase (AChE), resulting in a decline in enzymatic hydrolysate 1-naphthol (1-N). The fluctuation of the 1-N electrochemical response is proven to be a reliable indicator for assessing OPs neurotoxicity. Gelatin methacrylate hydrogel is used as a scaffold for 3D culture of PC12 cells, while zeolite imidazolate framework67@CoAl layered double hydroxides/multi-walled carbon nanotube composites enhance the sensitivity of the screen-printed carbon electrode.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Food Science & Technology
Y. J. H. Galani, C. Orfila, Y. Y. Gong
Summary: This paper reviews the importance of maize as staple food in Eastern and Southern Africa and its connection to micronutrient deficiencies in these regions. Micronutrient deficiencies, particularly among women and children, are prevalent in these regions. Maize consumption in these regions is also high. While maize can contribute to meeting dietary reference intakes, it lacks certain nutrients such as fats, calcium, and zinc. Successful strategies to address micronutrient deficiencies in these regions include maize fortification, increasing dietary diversity, and biofortification.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
